Vitaminas

Applications Arotinoid ethyl ester is a retinoid with a similar structure to vitamin A (R252000), and inhibits human epidermal keratinocyte RNase P activity, as well as tRNA biogenesis.
References Liao, W.; et al.: Zhongguo Linchuang Yaolixue Yu Zhiliaoxue, 19, 112 (2014); Papadimou, E.; et al.: Biol. Chem., 384, 457 (2003); Papadimou, E.; et al.: Skin Pharmacol. Physiol., 13, 345 (2000).

Stability Light and Temperature Sensitive
Applications 9-cis-13,14-Dihydroretinoic Acid, is a derivative of Retinal (R240000), corotenoid component of the visual pigments.
References Ball, et al.: Biochem. J., 42, 516 (1948), O’Brien, D.F., et al.: Science, 218, 961 (1982),

Applications MRL-871 is a novel RORγt inhibitor, binding to a previously unidentified allosteric pocket in the RORγt LBD.
References Scheepstra, Marcel., et al.:Nat. Commun., 6, 8833/1 (2015); Fauber, Benjamin P., et al.: Bioorganic Med. Chem. Lett., 25, 2907 (2015);

Applications Α hydroxylated metabolite of Vitamin D2 (V676040); a synthetic analog of Vitamin D.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Matsuoka, M. et al.: J. Nutrit. Sci. Vitaminol., 35, 253 (1989); Jones, G. et al.: Arch. Biochem. Biophys., 202, 450 (1980); Goff, J. et al.: J. Nutrit., 112, 1387 (1982);

Applications SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays.
References Wang, Y., et al.: ACS Chem. Biol., 5, 1029 (2010); Wang, Y., et al.: PLoS One, 7, 1 (2012)

Applications SC-58236 is a highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);

Applications Antagonizes Wnt/β-catenin/Tcf-mediated transcription as well as PPARγ and δ activity. Able to inhibit the recruitment of the co-activators β-catenin and GRIP1, both of which are activators for both pathways.
References Handeli, S., et al.: Mol. Cancer Ther., 7, 521 (2008),

Applications 17beta-Estradiol-16,16-d2 (CAS# 3188-46-3) is a useful isotopically labeled research compound.

Stability Hygroscopic! Store Under Inert Atmosphere.
Applications An active Biotinylation reagent.
References Giubellino, A., et al.: J. Med. Chem., 51, 7459 (2008), Wang, Z., et al.: Nat. Chem. Biol., 4, 557 (2008),

Applications SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
References Kojetin, D., et al.: ACS. Chem. Biol., 6, 131 (2011);

Applications Coenzyme Q2 is a redox carrier in the mitochondrial respiratory chain in eukaryotic cells. It has been used to investigate interaction of coenzyme Q with phosphatidylethanolamine membranes.
References Do, T., et al.: J. Biol Chem. 276, 18161 (2001); Gomez-Fernandez, J. C., et al.: Eur. J. Biochem. 259, 739 (1999);

Applications A metabolite of Budesonide (B689490), an antiinflammatory agent.
References Cserhati, T., et al.: J. Pharm. Biomed. Anal., 22, 25 (2000), Dilger, K., et al.: J. Clin. Pharmacol., 47, 1532 (2007), Buchwald, P., et al.: Steroids, 73, 193 (2008),

Applications Vitamin K1 2,3-Epoxide is a metabolite of Vitamin K1 (V676080), which is occurs widely in green plants, algae, and photosynthetic bacteria.
References Smee, D.F., et al.: Antimicrob. Agents Chemother., 23, 676 (1983), Miyamoto, T., et al.: Biochem. Pharmacol., 35, 839 (1986); Hassan, M.M.A., et al.: Anal. Profiles Drug Subs., 17, 449 (1988), Breton, J., et al.: Biochemistry, 33, 12405 (1994), Dowd, P., et al.: Science, 269, 1684 (1995);

Applications 13-cis-Retinyl Acetate is a derivative of 13-Cis-Retinol (R252110), an active metabolite of vitamin A.
References Shantz, E., et al.: J. Biol. Chem., 183, A61 (1950), Barua, A., et al.: Biochem. J., 164, 133 (1977), Brouwer, I., et al.: Nutr. Res. Rev., 14, 267 (2001), Grillenberger, M., et al.: Br. J. Nutr., 95, 379 (2006),

Applications The active labelled metabolite of Vitamin D2 (V676040).
References Lam, H., et al.: Science, 186, 1038 (1974), Dilworth, F., et al.: J. Biol. Chem., 270, 16766 (1995), Horst, R., et al.: Biochem. Pharmacol. 60, 701 (2000), Horst, R., et al.: J. Cell Biochem., 88, 282 (2003),

Applications Vitamin D5 is used in the synthetic preparation of 1α-Hydroxyvitamin D5 a promising chemopreventive agent for breast cancer.
References Moriarty, R.M., Albinescu, D.: J. Org. Chem., 70, 7624 (2005)

Applications GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
References Fowler, A.J., et. al.: J. Invest. Dermatol., 120, 246 (2003)

Stability Light Sensitive, Temperature Sensitive
Applications Echinenone is a protective carotenoid. Echinenone is an analogue of β-Carotene (C184250), the most important of the provitamins A. Widely distributed in the plant and animal kingdom. In plants it occurs almost always together with chlorophyll. Vitamin A precursor. Ultraviolet screen.
References Karrer, et al.: Helv. Chim. Acta, 12, 1142 (1929); Fischli, M., et al.: Helv. Chim. Acta, 58, 1584 (1975); Desmet, J., et al.: Biochem. Biophys. Acta, 912, 211 (1987); Tan, C., et al.: Food Chem., 92, 661 (2005); Chu, B., et al.: J. Agric. Food Chem., 55, 6754 (2007)