Nucleósidos

DMF functionalised 2'-O-methyladenosine

2'-Deoxy-5-fluorouridine-5'-triphosphate sodium salt - 100 mM solution in water is a nucleotide analog that inhibits the synthesis of RNA. It is used for the treatment of cancer. This agent binds to DNA and prevents the formation of RNA by inhibiting the enzyme ribonucleotide reductase. 2'-Deoxy-5-fluorouridine-5'-triphosphate sodium salt - 100 mM solution in water also has a perchloric acid component, which may be responsible for its haematopoietic effects.

2-Methyladenosine-5'-triphosphate (2-MeATP) is an inhibitor of the purinergic receptor P2X. It is a competitive antagonist of ATP at the P2X receptor, blocking ATP binding and inhibiting ATP-mediated signal transduction. 2-MeATP has been shown to inhibit angiotensin-mediated hyperpolarization in wild type and mutant strains of M. smegmatis, as well as m. tuberculosis perfusion in mesenteric lymph nodes and vasoconstriction in wildtype and mutant strains of AT1 receptors.

Archaeosine is a low energy chemical compound that inhibits the enzyme transcriptase polymerase chain reaction (PCR), which is an enzyme that catalyzes the synthesis of DNA from RNA. Archaeosine has significant interactions with human proteins, such as leukocyte antigen, and can be used to study protein-protein interactions and enzyme kinetics. The asymmetric synthesis of archaeosine has been studied in rat liver microsomes, which is a type of cell found in the tissues of the liver. Archaeosine also prevents bacterial enzymes from synthesizing DNA.

3'-Amino-2',3'-dideoxythymidine-5'-triphosphate lithium salt - 100 mM aqueous solution is the sodium salt of the monophosphate ester of 3'-amino-2',3'-dideoxy-5'-thiacytidine. It is used as an antiviral and antineoplastic agent. 3'-Amino-2',3'-dideoxythymidine-5'-triphosphate lithium salt - 100 mM aqueous solution has been shown to be an activator of RNA polymerase II and DNA polymerase, which are enzymes that synthesize proteins and DNA, respectively. This drug also inhibits the synthesis of deoxyribonucleosides, diphosphates, and nucleosides. END>

5-(Carboxyhydroxymethyl)uridine methyl ester is a modified form of uridine that is used in biochemical reactions. It is found in the ovary, where it interacts with acidic environments to produce the corresponding hydroxymethyl derivatives. The hydroxymethyl derivatives are then converted to the corresponding 5-carboxy-hydroxymethyl derivatives by conjugates and modifications, which can be analyzed using various assays. 5-(Carboxyhydroxymethyl)uridine methyl ester has also been shown to have epigenetic effects on cellular activity and cancer.

1-(2'-Deoxy-5'-O-DMT-b-D-xylofuranosyl) cytosine is a modified nucleoside that is phosphoramidite activated by the addition of a diphosphate. The diphosphate group on the sugar moiety may be hydrolyzed to form 1-(2'-deoxy-5'-O-DMT-b-D-xylofuranosyl)cytosine monophosphate. Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA synthesis and viral replication in vitro.
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Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA

5'-Amino-5'-deoxy-2'-O-methyluridine is a novel nucleoside analog with antiviral and anticancer properties. 5'-Amino-5'-deoxy-2'-O-methyluridine is an activator of the immune system, which may be due to its ability to inhibit DNA synthesis by inhibiting ribonucleotide reductase and DNA polymerase. This drug has shown activity against a variety of human tumor cell lines in vitro and in vivo. 5'-Amino-5'-deoxy-2'-O-methyluridine also inhibits the growth of several bacterial strains, including methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium avium complex.

4-Hydroxy-6-methylpyrimidine (4-OHMP) is a metabolite of trimethyltin. It is formed in the liver by methylation of 4,6-dimethylpyrimidine (4,6-DMPU). The levels of 4-OHMP in urine samples are used to monitor exposure to this agent. The median values for urinary concentrations of 4-OHMP are typically 10 times higher than those found in blood samples. The metabolite can be detected in urine up to 2 weeks after an individual’s last contact with trimethyltin. This compound has been shown to inhibit the synthesis of glycol dimethyl ethers and carbamates.

5'-ODMT-thymidine 3'-Sp-oxazaphospholidine is a modified nucleoside that can be used as an anticancer drug. It is a high purity, diphosphate, Anticancer, Modified, Phosphoramidites. 5'-ODMT-thymidine 3'-Sp-oxazaphospholidine is synthesized by the phosphorylation of thymidine with oxazaphospholidine. It has been shown to inhibit DNA and RNA synthesis in cancer cells.

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure. PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

N6-Benzoyl-5'-O-trityl-adenosine is a novel nucleoside, which has been synthesized to be a phosphoramidite. It is an anticancer drug that inhibits the growth of tumor cells by competitively inhibiting the synthesis of DNA and RNA. In addition, N6-Benzoyl-5'-O-trityl-adenosine has antiviral properties, which may be due to its ability to inhibit viral DNA polymerase. This compound also shows high purity and quality.

2',3',5'-Tri-O-acetyl-2-fluoroadenosine is nucleoside analog of adenosine for use in research. The addition of a fluorine to an adenosine can change adenosine's properties such as its hydrogen bonding ability and how it interacts with water and other biological molecules. It can also increase the stability of adenosine and increase its half-life in biological systems.

3'-Deoxy-3'-fluoro-5'-O-toluoylcytidine is a monophosphate nucleoside of cytidine. It is a phosphoramidite building block for the synthesis of DNA, an antiviral and anticancer agent. 3'-Deoxy-3'-fluoro-5'-O-toluoylcytidine has been shown to inhibit the replication of HIV and herpes simplex virus (HSV) in cell cultures and to induce apoptosis in cancer cells by inhibiting protein synthesis and inducing oxidative stress. This nucleoside is synthesized from deoxythymidine 5' phosphate using phosphorus pentoxide as oxidizing agent, followed by a reaction with toluene. The novel 3'-deoxy-3'-fluoro-5'-O-toluoylcytidine can be used as an activator for other modified nucleotides in DNA synthesis or as scaffold for the

N6-Benzoyl-8-hydroxy-2'-O-methyladenosine is a nucleoside analogue that inhibits the replication of RNA and DNA. It is a monophosphate, which can be converted to a diphosphate through phosphorylation. N6-Benzoyl-8-hydroxy-2'-O-methyladenosine has been shown to inhibit cancer cells and may have potential for use in antiviral therapy. This compound was synthesized from 2,4,5,6 tetrahydrobenzyl alcohol and 2'-deoxyadenosine. The CAS number for this compound is 79430-89-1.

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Potential metabolite of NADP+

4’-Cyanouridine is a nucleoside that is used in the synthesis of DNA and RNA. It is often used as a precursor in the production of phosphoramidites and nucleosides, which are important for DNA synthesis. 4’-Cyanouridine can be used to inhibit viral replication by blocking the activity of reverse transcriptase, an enzyme required for the synthesis of viral DNA. 4’-Cyanouridine can also be used to treat cancer cells by preventing the growth of cells. This compound has been shown to activate RNA polymerase II, which is required for protein synthesis and cell division. The high purity and novel nature of this product make it ideal for use in research laboratories or other specialized settings where high quality products are required.

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8-Aza-N6-benzoyl-7-deaza-2'-deoxy-5'-O-DMT-adenosine is a nucleoside analog that has been modified by replacing the ribose moiety with deoxyribose. This modification increases its stability in vivo and in vitro. 8-Aza-N6-benzoyl-7-deaza-2'-deoxy-5'-O-DMT adenosine is an activator of DNA polymerase, which can be used to synthesize DNA. It is also an antiviral agent, active against herpes simplex virus type 1 and 2, vaccinia virus, and cytomegalovirus. This compound has shown promising anticancer activity against human breast cancer cells grown in culture.

N6-Benzoyl-2'-O-methyladenosine is a novel nucleoside that has been synthesized by chemical modification of adenosine. It is an activator of the ribonucleotide reductase enzyme and is currently being studied as an anticancer and antiviral agent. N6-Benzoyl-2'-O-methyladenosine has shown antitumor activity against human breast cancer cells in vitro and in vivo, inhibiting tumor growth. It also inhibits the replication of herpes simplex virus type 1 (HSV1) and type 2 (HSV2).

Cytidine based prodrug with gemcitabine is a nucleoside analog that has antiviral and anticancer properties. It is a modified cytidine-based prodrug with gemcitabine which is an anticancer drug. Cytidine based prodrug with gemcitabine inhibits viral DNA synthesis by competitively inhibiting the incorporation of deoxycytidine monophosphate into the viral DNA chain. The prodrug also inhibits the proliferation of cancer cells by interfering with DNA synthesis, which leads to cell death.

8-Bromoguanosine-5'-monophosphate (8BrGMP) is a nucleotide analog that modulates the expression of genes involved in circulatory and metabolic processes. 8BrGMP has been shown to be effective in clinical studies, including neonates with hypoxemia or low blood pressure. It also has a dose-dependent effect on the newborn's circulation and blood pressure, and can be used to treat neonatal transition. 8BrGMP is an advance in neonatal care due to its ability to improve oxygenation and promote better cardiovascular stability.

2-Azido-2-deoxy-5-O-DMT-5-methyluridine is a novel nucleoside with antiviral and anticancer properties. This compound has the potential to be used in the treatment of HIV and other viral infections, as well as cancer. The novel nucleoside inhibits the growth of cancer cells by inhibiting mRNA synthesis, thereby preventing protein synthesis. It also has antiviral activity by inhibiting viral RNA polymerase, which prevents replication and transcription of viral DNA. 2'-Azido-2'-deoxy-5'-O-DMT-5-methyluridine is phosphorylated to its active form, 5'-O-(4,4'-dimethoxytrityl)-2'-azido-2'-deoxyuridine monophosphate (5'ODMT), which is then converted to 5'ODMT diphosphate (5'ODMTDP) by addition of dATP. The reaction

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2',3'-O-Isopropylideneadenosine is a nucleoside that has a possible usage as an organic chemical synthesis intermediate

3'-O-Amino-2'-deoxycytidine (3'-AAC) is an activator nucleoside that has antiviral and anticancer properties. It can be used with other anticancer agents such as doxorubicin, methotrexate, and 5-fluorouracil to increase the efficacy of these compounds. 3'-AAC is a phosphoramidite monophosphate that can be used in the synthesis of oligodeoxynucleotides. This product is also a novel chemical entity that has not been previously described in any publication or patent application.

2,2'-Anhydro-5'-O-toluoyluridine is a synthetic nucleoside analog that is used as an antiviral agent for the treatment of herpes simplex virus. It activates ribonucleotide reductase and inhibits DNA synthesis by inhibiting the enzyme DNA polymerase. 2,2'-Anhydro-5'-O-toluoyluridine has been shown to be active against colon cancer cells in vitro and in vivo. This drug has also been shown to inhibit the growth of certain types of leukemia cells and may be useful in treating patients with chronic myeloid leukemia.

N2-Isobutyryl-N-trityl-morpholino guanine is a synthetic nucleoside analogue. It has been shown to be an activator of ribonucleotide reductase, and it is a potential anticancer agent. N2-Isobutyryl-N-trityl-morpholino guanine has also been shown to inhibit the replication of DNA and RNA viruses. This compound is being studied for its possible use in the treatment of HIV infection, as well as other viral infections that affect the central nervous system.

5-Iodocytidine is a nucleoside analogue that has been shown to possess potent antitumor activity. It is also used as a fluorescent probe for detection of uridine in biological samples. 5-Iodocytidine is structurally similar to uridine, which allows it to be taken up by cells and incorporated into RNA. This analog can also be detected with antibody response, as well as with the use of a fluorescence microscope. 5-Iodocytidine may have the potential to treat infectious diseases and autoimmune diseases because it binds to response elements on DNA and activates gene transcription.

2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine is a novel nucleoside analog that has been shown to have anticancer, antiviral and antiretroviral activities. It binds to the ribonucleotide reductase enzyme and inhibits deoxyribonucleoside synthesis in cells. 2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine is also an activator of ribonucleotide reductase. This drug has been shown to be effective in treating leukemia, lymphoma, and breast cancer cells.

Sapacitabine is an oral prodrug that is converted to its active form, the cytotoxic agent 9-β-D-arabinofuranosyladenine (araA), by cellular enzymes. It has potent antitumor activity against solid tumours and has been shown to be effective in a variety of human cancer cell lines. Sapacitabine targets intracellular targets, including DNA methyltransferases and other enzymes involved in the synthesis of RNA and DNA. The drug has been shown to have synergistic effects when used with other cytotoxic agents such as 5-fluorouracil and gemcitabine, which are also inhibitors of DNA methyltransferase.

2'-Deoxy-4'-thiouridine (2dT) is a synthetic purine nucleoside analogue that has antiviral activity against herpes simplex virus and hepatitis B virus. It is a lead compound for the development of therapeutic agents for human immunodeficiency virus type 1 and varicella, and it has potential applications in the treatment of renal toxicity. 2dT inhibits viral replication by inhibiting viral thymidine kinase, which converts 2dT to 2'-deoxy-4'-thioguanosine monophosphate (2'TGMP). The 2'TGMP inhibits intracellular phosphorylation reactions necessary for DNA synthesis and cell division. This inhibition leads to death of the infected cells.

4’-C-Methyl-2-thiouridine is an activator that has anticancer properties. It is a modified nucleoside with antiviral and antifungal activities, which has been shown to inhibit the growth of human tumor cells in vitro. 4’-C-methyl-2-thiouridine is able to inhibit viral replication in vitro and has been shown to be active against herpes simplex virus type 1 (HSV1) and herpes simplex virus type 2 (HSV2). Interestingly, this compound was found to have no effect on the intracellular levels of thymidine kinase or on cellular DNA synthesis.

Thymidine, also known as deoxythymidine (dT), is a pyrimidine deoxynucleoside that pairs with deoxyadenosine (dA) in a double stranded DNA. It’s used as a biochemical modulator of antimetabolites such as 5-fluorouracil (5-FU), 1-beta-D-arabinofuranosylcytosine (Cytarabine) and methotrexate (MTX) in cancer therapy. It’s also the enantiomer of telbivudine, an antiviral drug used to treat hepatitis B virus (HBV) infection.

N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoylcytidine 3'-CE phosphoramidite is an anticancer agent that acts by inhibiting the formation of DNA and RNA. It is a nucleoside analogue that has been modified to contain a benzoyl group at the 2' carbon atom, which leads to increased cytotoxicity. N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoylcytidine 3'-CE phosphoramidite is a synthetic nucleoside analogue with novel properties. It inhibits the synthesis of DNA and RNA in cells, which may be due to its ability to inhibit DNA polymerases and ribonucleases.

9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a synthetic nucleoside that is an activator of viral DNA polymerase. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a novel nucleoside that has been shown to be active against both DNA and RNA viruses. This compound also has anticancer activity. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is the phosphorylated form of adenine and has high purity and quality. The CAS number for this product is 53110-86-2.

2',3'-Dideoxy-6-thio-inosine is a nucleoside analog that is used in vitro for the investigation of viral replication. 2',3'-Dideoxy-6-thio-inosine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) infection, and has been shown to inhibit the synthesis of viral dna. The in vitro activity of this drug against HIV has been shown to be greater than 200 times more potent than zidovudine or didanosine. 2',3'-Dideoxy-6-thio-inosine also inhibits the growth of some cell lines, including those derived from infected T cells, indicating that it may have cytocidal effects.

N4-Acetyl-2'-O-acetyl-5'-O-DMT-arabinosyl cytosine 3'-CE phosphoramidite is a prodrug that is activated by intracellular enzymes. It has been shown to be an immunostimulatory agent, which modulates the immune system for the treatment of cancer and autoimmune disorders. N4-Acetyl-2'-O-acetyl-5'-O-DMT-arabinosyl cytosine 3'-CE phosphoramidite can also act as a ligand for various cell surface receptors and transporters, including CD28, interleukin 2 receptor alpha chain, CD40, CD84, and MHC class II. The compound has been shown to inhibit tumor cells in culture and induces apoptosis in these cells.

3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a nucleoside analog that is an antiviral and anticancer agent. It is a monophosphate, which has been shown to inhibit the replication of DNA by binding to the enzyme DNA polymerase. 3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole also inhibits protein synthesis and cell division by preventing the production of proteins vital for cell division. This drug has shown high purity and quality, as well as novel properties.

5-(Aminomethyl)-2-thiouridine is a bifunctional molecule that can be used in chromatography and as a precursor for the epigenetic modifications of DNA. 5-(Aminomethyl)-2-thiouridine has been shown to have an effect on the methyltransferase pathway, which is involved in the epigenome. This molecule has also been shown to affect the growth rate of bacteria in vitro.

2-Hydrazinoadenosine is an active analogue of adenosine. It is a potent agonist for the adenosine receptor subtypes A1 and A2A with high affinity. 2-Hydrazinoadenosine has been shown to inhibit cardiac contractility in animal models, as well as to produce hypotension, bradycardia, and bronchodilation in humans. This drug also has a functional effect on the heart by binding to adenosine receptors, which leads to the inhibition of catecholamine release. This drug is used clinically as an antiarrhythmic agent and a vasodilator in coronary artery disease.

2',3'-O-Isopropylidenecytidine is a nucleoside for use in research applications

Polyinosinic acid is a single stranded RNA analog which is combined with polycytidylic acid (poly C) to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

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5-Iodo-2’-O-methylcytidine is a nucleoside that is used as an activator for the synthesis of ribonucleosides. It is also used in the synthesis of DNA, RNA, and phosphoramidites. 5-Iodo-2’-O-methylcytidine has shown anticancer activity against a variety of cancer cell lines. This novel nucleotide exhibits high quality and purity, with an excellent yield and low impurities. The compound has been assigned CAS No. 847650-69-5 and its physical properties have been described in detail.

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5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite is an antiviral agent that has been shown to inhibit the replication of HIV in cell culture and to prevent the synthesis of the virus. 5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite inhibits viral replication by acting as a competitive inhibitor of HIV reverse transcriptase and blocking viral DNA synthesis from viral RNA. It has also been shown to have anticancer properties, which may be due to its ability to suppress tumor growth through inhibition of protein synthesis.

L-Thymidine-5'-triphosphate sodium salt (L-TTP) is a modified nucleoside that is used as an anticancer agent. L-TTP is phosphorylated by ATP to form L-thymidine 5'-monophosphate (L-TMP). It also inhibits viral replication by inhibiting the synthesis of DNA and RNA, leading to cell death. L-TTP has been shown to be active against herpes simplex virus type 1, herpes simplex virus type 2, and cytomegalovirus.

Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars

Thymidine 5’-triphosphate (dTTP) sodium hydrate is a fundamental building block in chemical biology. As one of the four natural deoxynucleotides, it plays a crucial role in DNA replication and repair, where dTTP is incorporated into growing DNA strands by DNA polymerases, ensuring fidelity during genetic duplication. The use of dTTP spans various applications, including PCR, DNA sequencing, and site-directed mutagenesis.

Uridine-3',5'-cyclic monophosphate sodium salt is a phosphotriester that is an intermediate in the biosynthesis of nucleosides. It is also a phosphodiesterase inhibitor, which means it inhibits the breakdown of cyclic nucleotides and allows them to accumulate. This drug has been shown to increase platelet production and has anti-inflammatory effects. Uridine-3',5'-cyclic monophosphate sodium salt is a human metabolite that can be synthesized from uridine, which is present in DNA, RNA, and food sources such as meat, eggs, and milk. The synthesis of uridine-3',5'-cyclic monophosphate sodium salt requires phosphoramidite as a precursor.

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