Nucleósidos
Los nucleósidos son building blocks fundamentales de los ácidos nucleicos, compuestos por una base nitrogenada unida a una molécula de azúcar. En esta sección, puede encontrar una amplia variedad de nucleósidos esenciales para la investigación en biología molecular, bioquímica y farmacología. Estos compuestos juegan roles cruciales en la síntesis de ADN y ARN, y son vitales en varios procesos metabólicos. Los nucleósidos se utilizan para estudiar material genético, desarrollar terapias antivirales y anticancerígenas, y comprender los mecanismos celulares. En CymitQuimica, proporcionamos nucleósidos de alta calidad para apoyar sus necesidades de investigación y desarrollo, asegurando pureza y fiabilidad para sus aplicaciones experimentales.
Se han encontrado 3570 productos de "Nucleósidos"
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3’-b-C-Methyl-5-methyluridine
CAS:3’-b-C-Methyl-5-methyluridine is a phosphoramidite that is used as an antiviral agent. It is also known as (2’,3’)-O-(2-methoxyethyl) 5'-O-(4,4'-dimethoxytrityl)thymidine or 3’-b-C-Methyluridine. It has been shown to have anticancer properties in vitro and in vivo, and it can be used for the treatment of prostate cancer. 3’-b-C-Methyluridine is synthesized by the reaction of uracil with bis(trimethylsilyl)acetamide followed by reaction with methylamine. The synthesis of this drug was first reported in 1975.Pureza:Min. 95%7-Deaza-2'-deoxyinosine
CAS:7-Deaza-2'-deoxyinosine is a purine nucleoside analog that has been shown to be a hydrogen bond donor and formamide acceptor. This drug destabilizes duplex DNA by interfering with the formation of the hydrogen bonds between the bases, which may result in strand breakage. 7-Deaza-2'-deoxyinosine has also been shown to inhibit RNA polymerase activity, thereby inhibiting protein synthesis. It has been used as a tool for studying enzyme mechanisms and in solid phase synthesis.
Fórmula:C11H13N3O4Pureza:Min. 95%Forma y color:PowderPeso molecular:251.24 g/mol5'-Deoxy-5'-(methylthio)adenosine
CAS:5'-Deoxy-5'-(methylthio)adenosine is a nucleoside that has been shown to inhibit the growth of bowel cancer cells. 5'-Deoxy-5'-(methylthio)adenosine blocks the synthesis of DNA and RNA by inhibiting the action of enzymes involved in DNA metabolism. It also inhibits methionine synthase and phosphorylase, which are involved in protein synthesis. This compound has been shown to be effective in treating cancer tissues due to its ability to inhibit polymerase chain reactions and prevent the formation of cancerous cells.Fórmula:C11H15N5O3SPureza:(Hplc-Ms) Min. 98 Area-%Forma y color:White PowderPeso molecular:297.34 g/mol6-(β-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one
CAS:6-(β-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one is a novel nucleoside that has been shown to have anticancer and antiviral properties. In vitro studies have shown the compound to activate both DNA and RNA synthesis in cells. The compound also inhibits the replication of HIV viruses. 6-(β-D-2-Deoxyribofuranosyl)-3,4-dihydro-8H-pyrimido[4,5-c][1,2]oxazin-7-one is synthesized from ribonucleosides or deoxyribonucleosides through phosphoramidite chemistry. This product is available in high purity and high quality.Fórmula:C11H15N3O5Pureza:Min. 95%Forma y color:PowderPeso molecular:269.25 g/mol7-Deaza-2'-deoxy-2'-fluoroguanosine
7-Deaza-2'-deoxy-2'-fluoroguanosine is a nucleoside that can be phosphorylated to form 7-deaza-2'-deoxy-2'-fluoroguanosine 5'-triphosphate. This compound has antiviral properties and may be used as an antiviral agent in the treatment of HIV/AIDS. 7DGTP inhibits HIV replication by inhibiting the reverse transcriptase enzyme. The mechanism by which this drug exerts its effects is not yet well understood, but it is believed that it binds to the active site of the enzyme and prevents it from hydrolyzing dNTPs.Fórmula:C11H14FN4O4Pureza:Min. 95%Peso molecular:284.25 g/mol2'-C-Methylguanosine 5'-diphosphate triethylammonium salt
2'-C-Methylguanosine 5'-diphosphate triethylammonium salt is a synthetic nucleotide analog for use in researchFórmula:C11H16N5O11P2·C18H45N3Pureza:Min. 95%Forma y color:PowderPeso molecular:759.79 g/molN1,O2'-Dimethyladenosine
CAS:N1,O2'-Dimethyladenosine is a monophosphate that is an antiviral agent. It has been shown to be a potent activator of the tRNA synthetase enzyme and also inhibits viral DNA synthesis. This drug is synthesized from diphosphate and phosphoramidites. N1,O2'-Dimethyladenosine has been shown to be highly active against viruses such as HIV-1, HIV-2, and HCV. It is also used in the production of modified nucleosides for use in synthetic constructs with therapeutic applications.
Fórmula:C12H17N5O4Pureza:(%) Min. 95%Forma y color:PowderPeso molecular:295.29 g/molN4-Benzoyl-5'-O-Trityl-cytidine
CAS:N4-Benzoyl-5'-O-Trityl-cytidine (NBT) is a nucleoside that occurs in two forms: diphosphate and monophosphate. It is used as an activator of DNA and RNA synthesis, and as an antiviral agent. NBT has been shown to inhibit the replication of herpes simplex virus type 1, vaccinia virus and influenza virus in cell culture. It also inhibits the reverse transcriptase activity of HIV in vitro.
NBT is a novel deoxyribonucleoside phosphoramidite, which can be used in the synthesis of oligodeoxyribonucleotides for use in DNA sequencing or gene cloning applications.Fórmula:C35H31N3O6Pureza:Min. 95%Peso molecular:589.64 g/mol2'-O-Allylcytidine
CAS:2'-O-Allylcytidine is a synthetic nucleotide that contains an allylated amino function. It is synthesized by the regiospecific allylation of uridine and guanosine. 2'-O-Allylcytidine has been used in research studies for the synthesis of oligonucleotides with specific sequences and for high-yield production of synthons.Fórmula:C12H17N3O5Pureza:Min. 95%Forma y color:PowderPeso molecular:283.28 g/molE-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine
CAS:E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine is a nucleoside that is a modified form of uridine. It is a nucleotide analog that inhibits the synthesis of DNA and RNA and can be used to treat cancer. E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine is an activator that activates the phosphoramidites in the synthesis of DNA and RNA. This drug can also be used as antiviral therapy for herpes simplex virus type 1, influenza virus, and HIV. E-5-(2-Carbomethoxyvinyl)-2'-deoxyuridine has been shown to have anti-inflammatory properties by inhibiting prostaglandin synthesis.Fórmula:C13H16N2O7Pureza:Min. 95%Forma y color:White to off-white solid.Peso molecular:312.28 g/molGuanosine 5'-O-(2-thiodiphosphate) trilithium salt
CAS:Guanosine 5'-O-(2-thiodiphosphate) trilithium salt (GTPTS) is a membrane-permeable molecule that hyperpolarizes cells by inhibiting the movement of ions through the cell membrane. GTPTS is activated by extracellular calcium and potassium ions, which are involved in signal transduction pathways. It has been shown to inhibit the release of neurotransmitters, such as acetylcholine, dopamine, serotonin, and norepinephrine. GTPTS also blocks voltage-gated sodium channels, which leads to a reduction in neuronal excitability. The drug has been shown to have analgesic effects in animal models of pain and can be used to treat chronic pain due to nerve damage.Fórmula:C10H12Li3N5O10P2SPureza:Min. 85 Area-%Forma y color:PowderPeso molecular:477.06 g/mol1-(5'-O-Benzoyl-2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)thymine
CAS:1-(5'-O-Benzoyl-2'-deoxy-2'-fluoro-β-L-arabinofuranosyl)thymine is a modified nucleoside analog with structural modifications that enhance its biological properties, stability, and pharmaceutical potential. The compound features thymine (5-methyluracil) as the nucleobase, a pyrimidine derivative. The sugar component is 2'-deoxy-2'-fluoro-β-L-arabinofuranose, which includes the L-arabinose configuration, a departure from the natural D-ribose or D-deoxyribose configuration typically found in DNA and RNA, influencing how the molecule is recognized by biological systems. The 2'-fluoro substitution at the sugar position improves the compound's stability and resistance to enzymatic degradation, while also potentially enhancing its antiviral activity. A 5'-O-benzoyl group serves as a protecting group, safeguarding the 5'-hydroxyl group during synthesis.Fórmula:C17H17FN2O6Pureza:Min. 95%Peso molecular:364.33 g/mol6-Chloro-3'-deoxy-3'-fluoroinosine
6-Chloro-3'-deoxy-3'-fluoroinosine (6-Cl-dF) is an analog of the nucleotide base, adenosine. It has been shown to be effective in the treatment of cancer and HIV infections. 6-Cl-dF inhibits DNA synthesis by inhibiting the activity of ribonucleotide reductase and DNA polymerase, which are enzymes that are required for DNA replication. 6-Cl-dF has been shown to inhibit viral replication by blocking reverse transcriptase (an enzyme necessary for viral replication). This drug has also been shown to have antiangiogenic properties.Fórmula:C10H10ClFN4O3Pureza:Min. 95%Peso molecular:288.66 g/mol3'-Deoxy-3'-fluorothymidine
CAS:3'-Deoxy-3'-fluorothymidine is a nucleoside analog that is used to diagnose and treat cancer. It is a prodrug that is metabolized intracellularly by deoxycytidine kinase to the 3'-deoxy-3'-fluoro derivative of thymidine, which competes with natural thymidine for incorporation into DNA. Uptake of 18F-flouride (18F-FDG) in tumor cells has been shown to be proportional to the rate constant (k) of cellular uptake. This process can be quantified using positron emission tomography imaging. The cell cycle inhibitor activity of 3'-deoxy-3'-fluorothymidine has also been demonstrated in vitro and in vivo, inhibiting the proliferation of tumor cells and normal cells in culture, respectively.Fórmula:C10H13FN2O4Pureza:Min. 97 Area-%Forma y color:White Off-White PowderPeso molecular:244.22 g/mol2’,3’-Bis-O-tert-butyldimethylsilyl-5’-deoxy-4’,5’-Didehydrouridine
CAS:2’,3’-Bis-O-tert-butyldimethylsilyl-5’-deoxy-4’,5’-Didehydrouridine is a phosphoramidite that is used in the synthesis of DNA, RNA and nucleotide analogues. It has antiviral and antitumor properties and can be used for the treatment of leukemia. 2’,3’-Bis-O-tert-butyldimethylsilyl-5’-deoxyuridine is an activator for ribonucleotides and deoxyribonucleotides. It also has anticancer properties due to its ability to inhibit DNA replication, which may lead to apoptosis or cell death.Pureza:Min. 95%N6-Methyl-2'-C-methyladenosine
CAS:N6-Methyl-2'-C-methyladenosine is a modified nucleoside that belongs to the category of Deoxyribonucleosides. It is a novel compound with antiviral, anticancer, and antitumor properties. N6-Methyl-2'-C-methyladenosine inhibits viral replication by blocking the synthesis of DNA. This compound also has antiproliferative effects on cancer cells and retards tumor growth in animal models. N6-Methyl-2'-C-methyladenosine is synthesized from phosphoramidites in a two step process: first, the addition of methyl iodide to the phosphorus atom followed by nucleophilic substitution with methylamine.Fórmula:C12H17N5O4Pureza:Min. 95%Peso molecular:295.29 g/mol3'-Azido-3'-deoxy-5-fluoro-b-L-cytidine
CAS:3'-Azido-3'-deoxy-5-fluoro-b-L-cytidine is an antiviral drug. It is a modified nucleoside with phosphoramidite and azido groups. This product can be used as an activator for DNA synthesis, in anticancer drug development, as well as in the treatment of HIV. 3'-Azido-3'-deoxy-5-fluoro-b-L-cytidine has been shown to inhibit the growth of human tumor cells by inhibiting protein synthesis and enhancing the production of reactive oxygen species (ROS). It also inhibits the activity of ribonucleotide reductase, which is a critical enzyme for DNA synthesis.Pureza:Min. 95%4-Amino-2,6-dihydroxy-5-nitrosopyrimidine
CAS:4-Amino-2,6-dihydroxy-5-nitrosopyrimidine is a molecule that has been shown to be an effective inhibitor of the enzyme tyrosinase in the oxidation of tyrosine to DOPA, which is a precursor of melanin. It is believed that vibrational and structural changes during these reactions are responsible for the inhibitory effects. 4-Amino-2,6-dihydroxy-5-nitrosopyrimidine has also been shown to have anti cancer effects on glioma cells. This molecule binds to copper ions, forming a chelate ring that can stabilize reactive intermediates and terminate free radicals. The chlorine atom on this molecule may be responsible for its cytotoxic effects by reacting with nucleophilic sites on proteins. The functional groups on this molecule react with acid catalysts, such as protonation or dehydration reactions.Fórmula:C4H4N4O3Pureza:Min. 98 Area-%Forma y color:PowderPeso molecular:156.1 g/molGuanosine 5'-monophosphate disodium [1',2',3',4',5'-13C5]
Guanosine 5'-monophosphate disodium salt [1',2',3',4',5'-13C5] is a modified nucleoside that is used as an antiviral agent. It inhibits the synthesis of DNA by competitively inhibiting the activity of ribonucleotide reductase, which is required for de novo synthesis of DNA. Guanosine 5'-monophosphate disodium salt [1',2',3',4',5'-13C5] has been shown to be effective in treating cancer and may have anticancer properties due to its ability to inhibit the proliferation of tumor cells.Fórmula:C5C5H14N5O8P•Na2Pureza:Min. 95%Forma y color:PowderPeso molecular:414.64 g/mol4-(b-D-Ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one
CAS:Ribonucleosides, Deoxyribonucleosides and Activator are a group of synthetic compounds that are used in the synthesis of DNA. Ribonucleosides and Deoxyribonucleosides are nucleotides that contain ribose or deoxyribose as the sugar moiety. Activator is an activator for DNA polymerase, which catalyses the formation of a phosphodiester bond between two adjacent 3'-5' phosphate groups on a single strand of DNA. Ribonuclesides, Deoxyribonucleosides and Activator are used in recombinant DNA technology to synthesize DNA molecules containing modified bases. The CAS number for Ribonuclesides, Deoxyribonucleosides and Activator is 59892-40-9.
Fórmula:C10H12N4O5Pureza:Min. 95%Peso molecular:268.23 g/mol
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