Nucleósidos

9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a synthetic nucleoside that is an activator of viral DNA polymerase. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is a novel nucleoside that has been shown to be active against both DNA and RNA viruses. This compound also has anticancer activity. 9-(3'-O-methyl-β-D-xylofuranosyl)adenine is the phosphorylated form of adenine and has high purity and quality. The CAS number for this product is 53110-86-2.

2',3'-Dideoxy-6-thio-inosine is a nucleoside analog that is used in vitro for the investigation of viral replication. 2',3'-Dideoxy-6-thio-inosine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) infection, and has been shown to inhibit the synthesis of viral dna. The in vitro activity of this drug against HIV has been shown to be greater than 200 times more potent than zidovudine or didanosine. 2',3'-Dideoxy-6-thio-inosine also inhibits the growth of some cell lines, including those derived from infected T cells, indicating that it may have cytocidal effects.

N4-Acetyl-2'-O-acetyl-5'-O-DMT-arabinosyl cytosine 3'-CE phosphoramidite is a prodrug that is activated by intracellular enzymes. It has been shown to be an immunostimulatory agent, which modulates the immune system for the treatment of cancer and autoimmune disorders. N4-Acetyl-2'-O-acetyl-5'-O-DMT-arabinosyl cytosine 3'-CE phosphoramidite can also act as a ligand for various cell surface receptors and transporters, including CD28, interleukin 2 receptor alpha chain, CD40, CD84, and MHC class II. The compound has been shown to inhibit tumor cells in culture and induces apoptosis in these cells.

3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a nucleoside analog that is an antiviral and anticancer agent. It is a monophosphate, which has been shown to inhibit the replication of DNA by binding to the enzyme DNA polymerase. 3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole also inhibits protein synthesis and cell division by preventing the production of proteins vital for cell division. This drug has shown high purity and quality, as well as novel properties.

5-(Aminomethyl)-2-thiouridine is a bifunctional molecule that can be used in chromatography and as a precursor for the epigenetic modifications of DNA. 5-(Aminomethyl)-2-thiouridine has been shown to have an effect on the methyltransferase pathway, which is involved in the epigenome. This molecule has also been shown to affect the growth rate of bacteria in vitro.

2-Hydrazinoadenosine is an active analogue of adenosine. It is a potent agonist for the adenosine receptor subtypes A1 and A2A with high affinity. 2-Hydrazinoadenosine has been shown to inhibit cardiac contractility in animal models, as well as to produce hypotension, bradycardia, and bronchodilation in humans. This drug also has a functional effect on the heart by binding to adenosine receptors, which leads to the inhibition of catecholamine release. This drug is used clinically as an antiarrhythmic agent and a vasodilator in coronary artery disease.

2',3'-O-Isopropylidenecytidine is a nucleoside for use in research applications

Polyinosinic acid is a single stranded RNA analog which is combined with polycytidylic acid (poly C) to form a stable duplex structure known as Polyinosinic acid-polycytidylic acid (Poly I:C). PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations.  Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes. We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.
For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

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5-Iodo-2’-O-methylcytidine is a nucleoside that is used as an activator for the synthesis of ribonucleosides. It is also used in the synthesis of DNA, RNA, and phosphoramidites. 5-Iodo-2’-O-methylcytidine has shown anticancer activity against a variety of cancer cell lines. This novel nucleotide exhibits high quality and purity, with an excellent yield and low impurities. The compound has been assigned CAS No. 847650-69-5 and its physical properties have been described in detail.

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5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite is an antiviral agent that has been shown to inhibit the replication of HIV in cell culture and to prevent the synthesis of the virus. 5'-O-DMT-2'-ethylfluoro-5-methyluridine 3'-CE phophoramidite inhibits viral replication by acting as a competitive inhibitor of HIV reverse transcriptase and blocking viral DNA synthesis from viral RNA. It has also been shown to have anticancer properties, which may be due to its ability to suppress tumor growth through inhibition of protein synthesis.

L-Thymidine-5'-triphosphate sodium salt (L-TTP) is a modified nucleoside that is used as an anticancer agent. L-TTP is phosphorylated by ATP to form L-thymidine 5'-monophosphate (L-TMP). It also inhibits viral replication by inhibiting the synthesis of DNA and RNA, leading to cell death. L-TTP has been shown to be active against herpes simplex virus type 1, herpes simplex virus type 2, and cytomegalovirus.

Cytidine 5'-monophosphate sodium salt is a nucleotide that is found in RNA and DNA. Cytidine 5'-monophosphate sodium salt is an intermediate in the biosynthesis of uridine, choline, and saccharose. It also plays an important role in the immune system as it can be a precursor for immunoglobulins. The reaction rate of cytidine 5'-monophosphate sodium salt with lipase has been shown to be constant at pH 7.5-8.0 and 37°C. This product has been shown to have emulsifying properties by forming micelles with water-immiscible solvents such as hexane or heptane, which may be due to its ability to form hydrogen bonds with other molecules such as saccharose or guanosine. Cytidine 5'-monophosphate sodium salt can also be used as a chromatographic material for separating saccharose from other sugars

Thymidine 5’-triphosphate (dTTP) sodium hydrate is a fundamental building block in chemical biology. As one of the four natural deoxynucleotides, it plays a crucial role in DNA replication and repair, where dTTP is incorporated into growing DNA strands by DNA polymerases, ensuring fidelity during genetic duplication. The use of dTTP spans various applications, including PCR, DNA sequencing, and site-directed mutagenesis.

Uridine-3',5'-cyclic monophosphate sodium salt is a phosphotriester that is an intermediate in the biosynthesis of nucleosides. It is also a phosphodiesterase inhibitor, which means it inhibits the breakdown of cyclic nucleotides and allows them to accumulate. This drug has been shown to increase platelet production and has anti-inflammatory effects. Uridine-3',5'-cyclic monophosphate sodium salt is a human metabolite that can be synthesized from uridine, which is present in DNA, RNA, and food sources such as meat, eggs, and milk. The synthesis of uridine-3',5'-cyclic monophosphate sodium salt requires phosphoramidite as a precursor.

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