Nucleósidos

Agonist of toll-like receptors TLR7

4’-C-Methyl-5-methylcytidine is a phosphoramidite nucleoside that is used as a reagent in the synthesis of DNA. It is modified with a 4′-methyl and 5′-methyl group at the C4 and C5 positions of the cytosine base, respectively. The 4′-C methyl group is an antiviral agent that inhibits viral replication by inhibiting reverse transcriptase. The 5′-methyl group prevents deamination of cytosine residues by inhibiting uracil glycosylase. This product has anticancer properties due to its ability to inhibit cell division and activate apoptosis in tumor cells.

2'-Deoxy-2'-fluoro-L-uridine is a synthetic nucleoside analog of uridine where the sugar is both fluorinated at the 2' position and in the L-configuration, which is the mirror image of naturally occurring D-nucleosides. This modification makes it structurally distinct and biologically significant for certain applications in drug development and biochemical research.

2'-O-tert-Butyldimethylsilyl-N2-Isobutyryl-5'-O-tritylguanosine 3'-CE phosphoramidite is an anticancer nucleoside, which is used as a building block to synthesize DNA and RNA. The compound has been shown to be effective against HIV and herpes simplex virus. It also has antiviral effects against influenza A virus, cytomegalovirus, and Epstein Barr virus.

3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole is a nucleoside analog that is an antiviral and anticancer agent. It is a monophosphate, which has been shown to inhibit the replication of DNA by binding to the enzyme DNA polymerase. 3-Cyanovinyl-9-(5’-O-DMT-2’-deoxyribofuranosyl)carbazole also inhibits protein synthesis and cell division by preventing the production of proteins vital for cell division. This drug has shown high purity and quality, as well as novel properties.

1-(2'-Deoxy-5'-O-DMT-b-D-xylofuranosyl) cytosine is a modified nucleoside that is phosphoramidite activated by the addition of a diphosphate. The diphosphate group on the sugar moiety may be hydrolyzed to form 1-(2'-deoxy-5'-O-DMT-b-D-xylofuranosyl)cytosine monophosphate. Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA synthesis and viral replication in vitro.
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Cytidine is an antiviral and antifungal agent that is used in the treatment of herpes zoster, chronic myeloid leukemia, and other cancers. It has been shown to inhibit DNA

3'-Azido-3'-deoxy-5'-O-MMT-D3-thymidine is a novel nucleoside phosphoramidite that is used to synthesize oligonucleotides. It is an activator of ribonucleotide synthesis, a process in which the 5'-phosphate group is attached to the 3' hydroxyl group of a ribose sugar molecule. This phosphoramidite has antiviral and anticancer activities. 3'-Azido-3'-deoxy-5'-O-MMT-D3-thymidine has been shown to inhibit viral replication by inhibiting viral reverse transcriptase, an enzyme required for viral replication. It also inhibits DNA synthesis in cancer cells, leading to apoptosis (programmed cell death) and cell cycle arrest.

5'-O-Trityluridine is a nucleoside analogue that has been prepared as an oriented, oxidized, hydrogenated, xylene derivative of uridine. It is composed of ribofuranoside and uridine. The orientation is controlled by the use of trityl groups on the 5' and 3' hydroxyl groups. The alkali metal salt isomers are analysed using HPLC and GC. This compound interacts with phosphotriesters and cyclic phosphodiesters.

5-Fluorouridine-5'-triphosphate triethylammonium salt - aqueous solution is an activated nucleoside that is synthesized from the triethylamine salt of 5-fluorouridine. This product has antiviral and anticancer activities, and can be used as a DNA-synthesizing agent in the synthesis of deoxyribonucleosides. It has been shown to inhibit replication of human immunodeficiency virus (HIV) by inhibiting viral reverse transcriptase, as well as cytomegalovirus (CMV) by inhibiting viral DNA polymerase.

Fluorescein-5(6)-carboxamidocaproyl-[5(3-aminoallyl)2-deoxyuridine-5-triphosphate] is a modified nucleoside analog that is used as an antiviral agent against herpesviruses. This compound is phosphorylated by the virus encoded thymidine kinase, which converts it to the monophosphate form. Fluorescein-5(6)-carboxamidocaproyl-[5(3-aminoallyl)2-deoxyuridine-5-triphosphate] inhibits DNA synthesis by inhibiting viral DNA polymerase and has been shown to be active against human papillomavirus type 16 (HPV16) in vitro. It has also been shown to inhibit tumor cell proliferation and induce apoptosis in some types of cancer cells.

5-Chloro-2'-deoxyuridine is a nucleoside analog that inhibits DNA synthesis by inhibiting the enzyme thymidylate synthetase. It has been used for the treatment of bladder cancer and may also be beneficial in treating other cancers such as colon cancer. 5-Chloro-2'-deoxyuridine is taken up from the intestine by cells, where it is converted to thymidine monophosphate and then to thymidine diphosphate, which inhibits DNA synthesis by interfering with cell division. The mechanism of action is similar to that of cytosine arabinoside, but it does not require activation by intracellular enzymes. 5-Chloro-2'-deoxyuridine can cause cell lysis and can inhibit protease activity during cell culture, which makes it a useful tool for purifying proteins or peptides. The drug has been shown to be an analog of cytosine arabinos

9-[2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-toluoyl-b-L-ribofuranosyl)-6-chloropurine is a modified nucleoside. It is synthesized by attaching an acetyl group to the 2' position of the sugar moiety and a toluoyl group to the 3' position of the ribose moiety. 9-[2'-O-Acetyl-3'-azido-3'-deoxy-5'-O-toluoyl]-6 chloropurine has been shown to be an activator of RNA polymerase II and III, which are involved in transcription and replication. This drug also has antiviral properties against influenza virus, herpes simplex virus type 1, Epstein Barr Virus (EBV), and HIV as well as anticancer activity against human cells. 9-[2'-O-Acetyl]-6 chlor

8-Bromocyclic adenosine diphosphate ribose sodium salt (8BCAR) is a cytosolic cyclase inhibitor that inhibits the synthesis of cyclic adenosine monophosphate (cAMP). 8BCAR blocks the activation of protein kinase A, which is an enzyme involved in the phosphorylation of cAMP. 8BCAR has been shown to inhibit cardiac hypertrophy induced by growth factor-β1 and to increase mitochondrial membrane potential, as well as to suppress cardiomyocyte apoptosis. In addition, this drug can be used for the treatment of cancers such as leukemia and lymphoma.

2’C-Methyl-2-thiouridine is a novel nucleoside phosphoramidite that has been synthesized to serve as an activator for DNA polymerases. 2’C-Methyl-2-thiouridine is a potent antiviral agent that inhibits the replication of the hepatitis C virus in vitro. It also has antiproliferative effects against certain cancer cells and can be used as an anticancer drug. 2’C-Methyl-2-thiouridine contains a methylated thiol group, which confers a high degree of resistance to degradation by thiols, including glutathione (GSH). This compound is stable to hydrolysis and may be used in the synthesis of deoxyribonucleosides or monophosphate nucleotides.

2'-Deoxy-4'-thiouridine (2dT) is a synthetic purine nucleoside analogue that has antiviral activity against herpes simplex virus and hepatitis B virus. It is a lead compound for the development of therapeutic agents for human immunodeficiency virus type 1 and varicella, and it has potential applications in the treatment of renal toxicity. 2dT inhibits viral replication by inhibiting viral thymidine kinase, which converts 2dT to 2'-deoxy-4'-thioguanosine monophosphate (2'TGMP). The 2'TGMP inhibits intracellular phosphorylation reactions necessary for DNA synthesis and cell division. This inhibition leads to death of the infected cells.

8-Bromoguanosine (8BrG) is a potent inhibitor of cyclase enzymes that lead to the formation of cyclic guanosine monophosphate (cGMP). It has been shown to inhibit signal pathways, such as those regulated by the G protein-coupled receptor (GPCR), which are activated by the 2-adrenergic receptor. 8BrG has been shown to be effective against C. glabrata and other fungi and has been used in experimental models for infectious diseases.

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5-(3-Hydroxypropyn-1-yl)uridine is a modified nucleoside that can be used as an antiviral or anticancer drug. It is an activator of the enzyme ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides. 5-(3-Hydroxypropyn-1-yl)uridine has been shown to inhibit the growth of various cancer cells in vitro and in vivo. This drug has also been shown to have antiviral activity against herpes simplex virus type 1 (HSV-1).

5’-Deoxy-5’-iodo-2’-O-methyl-5-methyluridine is a monophosphate nucleoside. It is an antiviral and anticancer agent that inhibits viral replication by inhibiting the synthesis of viral DNA. It also has been shown to have antitumor activity, but it can only be used in cancer treatments when combined with other drugs such as 5FU. The chemical formula for 5’-Deoxy-5’-iodo-2’O methyl -5 methyl uridine is C10H14N4O8P.

5-Methyl-7-(2-C-methyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a synthetic nucleoside analog of 2'-deoxyadenosine. It is an activator of DNA synthesis and replication by virtue of its ability to inhibit the enzyme ribonucleotide reductase. The compound has antiviral and anticancer activities, as well as antitumor activity. 5-Methyl-7-(2-C-methyl-b-Dribofuranosyl)-7H-[1,2] pyrrolo[2,3]-d]pyrimidin--4--amine has shown good results in treating chronic myelogenous leukemia.

2'-Deoxy-2'-fluoro-5-methylcytidine is a nucleoside analog that is a modified version of cytidine, where the sugar (deoxyribose) has a fluoro modification at the 2' carbon and a methyl group is attached at the 5' position of the cytosine base. This modification confers unique properties that can be useful in research and drug development.

N1-Methylguanosine is a methylated nucleotide that is incorporated into the growing DNA chain during protein synthesis. The incorporation of N1-methylguanosine into the growing DNA chain can cause frameshifting, which creates an unusual amino acid sequence. This effect has been shown in model organisms, such as Saccharomyces cerevisiae and Escherichia coli. In these organisms, N1-methylguanosine has been shown to induce cancer when added to the growth medium. It is also found in urine samples from people with bladder cancer and has been used to identify urinary tract cancers. Titration calorimetry studies have shown that N1-methylguanosine binds to a chelate ligand and forms a disulfide bond with cysteine residues on proteins or peptides, which may lead to mitochondrial dysfunction by interfering with hydrogen bonding interactions. Messenger RNA studies show that N1-methylguanosine inhibits translation of mRNA by binding to

N6-Benzoyl-2'-O-methyladenosine is a novel nucleoside that has been synthesized by chemical modification of adenosine. It is an activator of the ribonucleotide reductase enzyme and is currently being studied as an anticancer and antiviral agent. N6-Benzoyl-2'-O-methyladenosine has shown antitumor activity against human breast cancer cells in vitro and in vivo, inhibiting tumor growth. It also inhibits the replication of herpes simplex virus type 1 (HSV1) and type 2 (HSV2).

Cis-2'-O-methylcytidine is a modified nucleoside that has shown antiviral and anticancer activity. It is a monophosphate analog of cytidine with high antiviral activity against HIV, HSV-1, HSV-2, EBV, and CMV. Cis-2'-O-methylcytidine also inhibits tumor growth in mice by inhibiting the synthesis of DNA. Cis-2'-O-methylcytidine has been synthesized from ribonucleosides and deoxyribonucleosides to provide high purity and quality.

6-Amino-4-hydrazino-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a nucleoside phosphoramidite which is used in the synthesis of oligonucleotides. It is a novel modified nucleoside and has antiviral and anticancer activities. 6-Amino-4-hydrazino-1-(b-D ribofuranosyl)-1H pyrazolo[3,4 d]pyrimidine can be used as an activator for 2'-deoxyribonucleotide synthesis and an inhibitor of ribonucleotide synthesis.

2'-Deoxyguanosine-5'-carboxylic acid is a synthetic nucleoside that has antiviral and anticancer properties. It is an activator of DNA polymerase, which is used in the synthesis of DNA. 2'-Deoxyguanosine-5'-carboxylic acid also inhibits the activity of ribonucleotide reductase and deoxyribonucleotide reductase, which are enzymes that catalyze the conversion of ribose-5-phosphate to deoxyribose-5-phosphate. This substance also blocks viral replication by inhibiting RNA synthesis in cells infected with HIV or herpes simplex virus type 1.

Inhibitor of uridine monophosphate synthase

Cytidine based prodrug with gemcitabine is a nucleoside analog that has antiviral and anticancer properties. It is a modified cytidine-based prodrug with gemcitabine which is an anticancer drug. Cytidine based prodrug with gemcitabine inhibits viral DNA synthesis by competitively inhibiting the incorporation of deoxycytidine monophosphate into the viral DNA chain. The prodrug also inhibits the proliferation of cancer cells by interfering with DNA synthesis, which leads to cell death.

3'-Azido-3'-deoxythymidine-5'-monophosphate lithium salt - 100 mM aqueous solution is an azidothymidine (AZT) analog that inhibits HIV replication. AZT is a nucleoside reverse transcriptase inhibitor that blocks the progression of HIV by preventing the virus from duplicating its DNA. This product has been shown to be effective in treating AIDS and related diseases, as well as other infectious diseases such as hepatitis B and C. 3'-Azido-3'-deoxythymidine-5'-monophosphate lithium salt - 100 mM aqueous solution is often used in combination with other drugs to increase their efficacy. It has also been shown to be an effective chemotherapeutic agent against cancer cells.

N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoylcytidine 3'-CE phosphoramidite is an anticancer agent that acts by inhibiting the formation of DNA and RNA. It is a nucleoside analogue that has been modified to contain a benzoyl group at the 2' carbon atom, which leads to increased cytotoxicity. N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-toluoylcytidine 3'-CE phosphoramidite is a synthetic nucleoside analogue with novel properties. It inhibits the synthesis of DNA and RNA in cells, which may be due to its ability to inhibit DNA polymerases and ribonucleases.

3’-Azido-3’-deoxy-2-thiouridine is an antiviral agent that is used to synthesize phosphoramidites for the preparation of modified oligonucleotides. 3’-Azido-3’-deoxy-2-thiouridine has been shown to inhibit cancer growth and induce apoptosis in cancer cells, suggesting that it may have anticancer properties. It is also a novel deoxyribonucleoside that can be used as a building block for the synthesis of ribonucleosides. 3’-Azido-3’-deoxy-2-thiouridine is a high quality product with high purity and excellent activator properties. This product has CAS No. 2305416–00–4 and can be used in pharmaceuticals, biotechnology, and other chemical applications.

7-(Aminomethyl)-7-deazaadenosine is a nucleoside that has antiviral and anticancer properties. It is a novel compound, and its synthesis involves the use of activated 2′-deoxyribonucleosides. This compound is synthesized by reacting 7-amino-7-deazaguanine with an appropriate phosphoramidite at room temperature in the presence of an activator such as ammonium hydroxide or pyridine. The product can be purified by recrystallization from methanol, followed by chromatography on silica gel using a gradient elution system. The purity of this compound can be determined by HPLC analysis with UV detection at 254 nm.
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Thymidine-3',5'-diphosphate sodium salt is a nucleoside that is used in the synthesis of oligonucleotides. It is an antiviral and anticancer agent. Thymidine-3',5'-diphosphate sodium salt has been shown to inhibit DNA synthesis, leading to cell death. It also has been shown to be effective against Hepatitis B virus and HIV-1.

N4-Acetyl-5-methylcytidine is a novel, modified nucleoside with antiviral and anticancer properties. It is an activator of RNA polymerase II and inhibits DNA synthesis by inhibiting the activity of DNA polymerase. N4-Acetyl-5-methylcytidine has been shown to be effective in treating cancers that are sensitive to chemotherapy, such as lymphomas, myelomas, and leukemias. It can be used as a substitute for cytosine in the synthesis of oligonucleotides and phosphoramidites.

8-Aza-7-deaza-2'-deoxyadenosine is a single-stranded DNA analogue that is used as a conjugate to deliver drugs to cells. It has been shown to be effective in the treatment of HIV by suppressing viral replication and the production of infectious virions. The drug is photolabile, which means it can be activated with light and then delivered to cells. 8-Aza-7-deaza-2'-deoxyadenosine has also been shown to inhibit the growth of human immunodeficiency virus (HIV) in vitro, but does not inhibit the growth of other viruses such as herpes simplex virus type 1 or adenovirus.

The phosphoramidite 7-Deaza-2'-deoxy-7-iodoguanosine is a modified nucleotide that is used in the synthesis of DNA. This compound has antiviral and anticancer properties, as it inhibits viral replication by preventing the synthesis of viral RNA or DNA. It also prevents the production of cancer cells by inhibiting ribonucleotide reductase, an enzyme that reduces ribonucleotides to deoxyribonucleotides for DNA synthesis. The purity of this product is high and the novel nature of this product makes it a valuable reagent for research.

2',3'-Dideoxy-6-thio-inosine is a nucleoside analog that is used in vitro for the investigation of viral replication. 2',3'-Dideoxy-6-thio-inosine is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) infection, and has been shown to inhibit the synthesis of viral dna. The in vitro activity of this drug against HIV has been shown to be greater than 200 times more potent than zidovudine or didanosine. 2',3'-Dideoxy-6-thio-inosine also inhibits the growth of some cell lines, including those derived from infected T cells, indicating that it may have cytocidal effects.

3'-b-Amino-2',3'-dideoxy-5'-O-trityl-5-methyluridine is a phosphoramidite, which is an intermediate in the synthesis of nucleosides. It is a novel deoxyribonucleoside that has been modified to include a methyl group at the 5' position. 3'-b-Amino-2',3'-dideoxy-5'-O-trityl-5-methyluridine is often used as an activator for DNA polymerases and ribonucleases, as well as for the synthesis of ribonucleosides. This product has shown anticancer activity by inhibiting RNA synthesis.

2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite is a nucleoside that is used in the synthesis of DNA. It is an antiviral and anticancer agent that has been shown to have anti-inflammatory properties. 2'-Deoxy-5'-O-DMT-pseudouridine 3'-CE phosphoramidite inhibits viral replication by inhibiting the synthesis of viral RNA, which prevents the production of proteins necessary for viral reproduction. The modified monophosphate form of this nucleoside is also a potent inhibitor of cancer cells in vitro and in vivo.

2'(3')-O-(4-Benzoyl)benzoyladenosine-5'-triphosphate triethylammonium salt is a nucleoside analog of Adenosine-5'-triphosphate (ATP), a key player in cellular energy transfer. 2'(3')-O-(4-Benzoyl)benzoyl has been added to this molecule as well as a triethylammonium salt which helps to increase the stability of the molecule in solutions. 2'(3')-O-(4-Benzoyl)benzoyladenosine-5'-triphosphate triethylammonium salt has potential use as a tool for understanding how cells use ATP and how changes to ATP affect cellular processes. Other possible uses are in the study of how ATP interacts with enzymes.

N6-Benzoyl-2'-deoxy-5'-O-DMT-adenosine 3'-O-succinate triethylammonium salt is a novel nucleoside analog that has antiviral and anticancer properties. It is a ribonucleotide with an N6-(benzoyl)-2'-deoxyadenosine base linked to the 3' position of the sugar through an acetyl group, with a succinic acid moiety at the 5' position. This drug inhibits DNA synthesis and has been shown to block HIV replication in vitro. It also has activity against human papillomavirus type 16 (HPV16) infections in vivo.

2'-Bromo-2'-deoxyuridine is a synthetic nucleoside analog of deoxyuridine, in which the 2'-hydroxyl group of the ribose sugar is replaced with a bromine atom (Br) at the 2' position. This modification allows it to be incorporated into DNA during DNA synthesis, where it can replace the normal thymidine. This molecule can potentially be used in molecular biology and cell biology as a thymidine analog to study DNA replication, cell proliferation, and DNA repair.

2,2'-Anhydro-5'-O-toluoyluridine is a synthetic nucleoside analog that is used as an antiviral agent for the treatment of herpes simplex virus. It activates ribonucleotide reductase and inhibits DNA synthesis by inhibiting the enzyme DNA polymerase. 2,2'-Anhydro-5'-O-toluoyluridine has been shown to be active against colon cancer cells in vitro and in vivo. This drug has also been shown to inhibit the growth of certain types of leukemia cells and may be useful in treating patients with chronic myeloid leukemia.

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2'-Deoxyinosine is an antimicrobial peptide that has been shown to have potent activity against Gram-positive bacteria, including Staphylococcus aureus. 2'-Deoxyinosine binds to the 3′-hydroxyl group of nucleic acid, preventing DNA replication and transcription. This binding also prevents ribosomal RNA from binding to the ribosome, inhibiting protein synthesis. 2'-Deoxyinosine has been detected using a highly sensitive optical sensor and can be used as a model system for studying the interaction between dsDNA duplexes and other biomolecules. The pharmacokinetic properties of this molecule have been determined in rats by measuring its concentration in serum over time after injection. These data were then used to determine the amount of 2'-deoxyinosine that was needed to inhibit bacterial growth in water samples.

1,3-Dimethylpseudouridine is a methylated derivative of pseudouridine, which is a naturally occurring modified nucleoside found in RNA. This compounds can be used in research applications

N2-Isobutyryl-N-trityl-morpholino guanine is a synthetic nucleoside analogue. It has been shown to be an activator of ribonucleotide reductase, and it is a potential anticancer agent. N2-Isobutyryl-N-trityl-morpholino guanine has also been shown to inhibit the replication of DNA and RNA viruses. This compound is being studied for its possible use in the treatment of HIV infection, as well as other viral infections that affect the central nervous system.