Sistema complementario
El sistema complementario es una parte crucial de la respuesta inmune, compuesto por una serie de pequeñas proteínas que mejoran la capacidad de los anticuerpos y las células fagocíticas para eliminar patógenos de un organismo. Estas proteínas trabajan juntas para opsonizar patógenos, inducir respuestas inflamatorias y lisar directamente las membranas de los patógenos, desempeñando un papel vital en la inmunidad innata y la función inmunitaria general. En CymitQuimica, ofrecemos proteínas del sistema del complemento de alta calidad para apoyar sus estudios inmunológicos e investigaciones clínicas.
Se han encontrado 172 productos de "Sistema complementario"
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MASP2 Protein, Mouse, Recombinant (His)
MASP2 Protein, Mouse, Recombinant (His) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:46.6 kDa (predicted). Due to autocatalytic cleavage, the protein migrates to 18-20 kDa&27-30 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-01126
5µg80,00€10µg117,00€20µg184,00€50µg363,00€100µg601,00€200µg1.084,00€500µg2.331,00€LEP(116-130)(mouse)TFA(258276-95-8 free base)
LEP(116-130)(mouse) is a synthetic leptin peptide fragment.Fórmula:C66H110F3N19O26SPureza:99.93%Forma y color:SolidPeso molecular:1674.77BCX 1470 methanesulfonate
CAS:BCX 1470 inhibits factor D & C1s better than trypsin (IC50: 96 nM & 1.6 nM, 3.4- & 200-fold).Fórmula:C15H14N2O5S3Forma y color:SolidPeso molecular:398.48Avacopan
CAS:Avacopan (CCX168) is a C5aR antagonist with selective and oral activity. Avacopan can be used to treat ANCA-related vasculitis. Cost-effective and quality-assured.Fórmula:C33H35F4N3O2Pureza:97% - 99.9%Forma y color:SolidPeso molecular:581.64Leukadherin-1
CAS:Leukadherin-1 boosts CD11b/CD18 adhesion, lowers leukocyte movement, cuts inflammation.Fórmula:C22H15NO4S2Pureza:98.49% - 98.93%Forma y color:SolidPeso molecular:421.49PMX 53 acetate(219639-75-5 free base)
CAS:PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50Fórmula:C49H69N11O9Pureza:99.91%Forma y color:SolidPeso molecular:956.16Ref: TM-TP2334
1mg105,00€5mg233,00€10mg344,00€25mg532,00€50mg735,00€100mg982,00€200mg1.333,00€1mL*10mM (DMSO)359,00€C3a 70-77 2TFA(63555-63-5(free base))
C3a 70-77 2TFA(63555-63-5(free base)) (Complement 3a (70-77)) is an octapeptide corresponding to the COOH terminus of C3a.Fórmula:C39H63N13O14Pureza:>99.99%Forma y color:SolidPeso molecular:1052.00ADH-503
CAS:ADH-503 (GB1275) is an orally available, allosteric CD11b small molecule agonist.Cost-effective and quality-assured.Fórmula:C27H28N2O5S2Pureza:99.03% - >99.99%Forma y color:SolidPeso molecular:524.7Ref: TM-T7776
2mg34,00€5mg49,00€10mg75,00€25mg120,00€50mg178,00€100mg259,00€200mg384,00€1mL*10mM (DMSO)52,00€Complement factor D-IN-2
CAS:Complement factor D-IN-2 is an inhibitor of Complement factor D and reduces the excessive activation of complement factor D.Fórmula:C27H24BrN7O3Pureza:99.53%Forma y color:SolidPeso molecular:574.43Ref: TM-T38332
1mg105,00€5mg241,00€10mg360,00€25mg637,00€50mg900,00€100mg1.170,00€200mg1.584,00€1mL*10mM (DMSO)299,00€Eculizumab
CAS:Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5Pureza:98.20%Forma y color:LiquidPeso molecular:145.74 kDaDanicopan
CAS:Danicopan (ACH-4471), an oral factor D inhibitor, binds strongly (Kd 0.54 nM) and may treat PNH and aHUS.Fórmula:C26H23BrFN7O3Pureza:99.94%Forma y color:SolidPeso molecular:580.41Ref: TM-T8509
1mg90,00€2mg129,00€5mg203,00€10mg310,00€25mg527,00€50mg755,00€100mg1.044,00€1mL*10mM (DMSO)260,00€JR14a
CAS:JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.Fórmula:C25H26Cl2N4O3SPureza:99.76%Forma y color:SolidPeso molecular:533.47TLQP 21 acetate
TLQP 21 acetate: Agonist for C3aR1, EC50 - 10.3 μM (mouse), 68.8 μM (human); VGF-derived with endo/extraendocrine traits.Fórmula:C109H174N40O28Pureza:99.99%Forma y color:SolidPeso molecular:2492.8Compstatin control peptide acetate
CAS:Compstatin control peptide acetate is an inhibitor of complement protein C3 by binding and inhibiting the cleavage of complement C3.Fórmula:C66H101N23O17Pureza:99.02%Forma y color:Odour SolidPeso molecular:1488.65Compstatin
CAS:Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.
Fórmula:C66H99N23O17S2Pureza:>99.99%Forma y color:SolidPeso molecular:1550.77Iptacopan hydrochloride
CAS:Iptacopan hydrochloride (LNP023 hydrochloride) is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM.Fórmula:C25H31ClN2O4Pureza:98.89% - 99.89%Forma y color:SolidPeso molecular:458.98Ref: TM-T9189
1mg54,00€2mg77,00€5mg114,00€10mg185,00€25mg334,00€50mg558,00€100mg928,00€200mg1.251,00€1mL*10mM (DMSO)114,00€AMY-101 acetate
AMY-101 acetate (Cp40 acetate) is a peptide, an inhibitor of C3 Complement in gingivitis and periodontitis, reduces inflammation and lowers MMP-8 and MMP-9.Fórmula:C85H121N23O20S2Pureza:98.80% - 99.98%Forma y color:SolidPeso molecular:1849.14Complement C5a Protein, Human, Recombinant
Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E.Pureza:SDS-PAGE: 94.9%; SEC-HPLC: 93.5%Forma y color:Lyophilized PowderPeso molecular:8.3 kDa (predicted); 8.3 kDa (reducing conditions)Complement C3 Protein, Bovine, Recombinant (His & SUMO)
Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:39.5 kDa (predicted)Ref: TM-TMPH-00231
1mg2.350,00€5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€Complement C5a Protein, Pig, Recombinant (His)
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process.Forma y color:Lyophilized PowderPeso molecular:10.6 kDa (predicted)Ref: TM-TMPH-03107
5µg144,00€10µg232,00€20µg387,00€50µg573,00€100µg810,00€200µg1.142,00€500µg1.811,00€Complement factor D Protein, Rat, Recombinant (His & Myc)
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternateForma y color:Lyophilized PowderPeso molecular:29.8 kDa (predicted)Ref: TM-TMPH-03271
1mg2.368,00€5µg57,00€10µg89,00€20µg128,00€50µg219,00€100µg342,00€200µg607,00€500µg1.334,00€C1QA Protein, Human, Recombinant (His & Myc)
C1QA Protein, Human, Recombinant (His & Myc) is expressed in E. coli.Forma y color:Lyophilized PowderPeso molecular:30.7 kDa (predicted)Ref: TM-TMPH-01128
1mg1.700,00€5µg84,00€10µg120,00€20µg193,00€50µg290,00€100µg416,00€200µg631,00€500µg1.123,00€C5AR1 Protein-VLP, Human, Recombinant (His)
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.Forma y color:Lyophilized PowderPeso molecular:41.1 kDa (predicted)Ref: TM-TMPH-01022
5µg268,00€10µg448,00€20µg744,00€50µg1.218,00€100µg1.737,00€200µg2.925,00€500µg5.832,00€C1QA Protein, Mouse, Recombinant (His)
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.Pureza:90% - 92%Forma y color:Lyophilized PowderPeso molecular:25.6 kDa (predicted)Complement C8g Protein, Human, Recombinant (His)
C8 is a constituent of the membrane attack complex.Pureza:95%Forma y color:Lyophilized PowderPeso molecular:26.4 kDa (predicted)Ref: TM-TMPH-01134
1mg1.700,00€5µg84,00€10µg120,00€20µg193,00€50µg290,00€100µg416,00€200µg631,00€500µg1.123,00€Complement factor D Protein, Rat, Recombinant (His)
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternateForma y color:Lyophilized PowderPeso molecular:27.8 kDa (predicted)Ref: TM-TMPH-03272
1mg2.758,00€5µg124,00€10µg193,00€20µg331,00€50µg485,00€100µg668,00€200µg1.027,00€500µg1.756,00€C5AR1 Protein, Mouse, Recombinant (MBP & His-Avi), Biotinylated
Expression system: E. coli
Length: 306-351, Partial
Activity: Not TestedForma y color:Lyophilized PowderPeso molecular:52.8 kDa (Predicted)Ref: TM-TMPH-04213
1mg1.839,00€5µg143,00€10µg229,00€20µg382,00€50µg480,00€100µg565,00€200µg812,00€500µg1.314,00€Properdin Protein, Mouse, Recombinant (His & Myc)
A positive regulator of the alternate pathway of complement.Forma y color:Lyophilized PowderPeso molecular:53 kDa (predicted)Ref: TM-TMPH-02845
5µg197,00€10µg329,00€20µg552,00€50µg1.044,00€100µg1.701,00€200µg2.673,00€500µg5.113,00€CR1 Protein, Human, Recombinant
Expression system: E. coli
Length: 41-234, Partial
Activity: Not TestedForma y color:Lyophilized PowderPeso molecular:21.6 kDa (Predicted)Ref: TM-TMPH-03875
1mg1.700,00€5µg133,00€10µg212,00€20µg353,00€50µg445,00€100µg520,00€200µg747,00€500µg1.209,00€C5AR1 Protein, Mouse, Recombinant (His & KSI)
Expression system: E. coli
Length: 306-351, Partial
Activity: Not TestedForma y color:Lyophilized PowderPeso molecular:20.4 kDa (Predicted)Ref: TM-TMPH-04212
1mg1.783,00€5µg90,00€10µg144,00€20µg231,00€50µg331,00€100µg435,00€200µg660,00€500µg1.180,00€Properdin Protein, Mouse, Recombinant (His)
A positive regulator of the alternate pathway of complement.Forma y color:Lyophilized PowderPeso molecular:51.9 kDa (predicted)Ref: TM-TMPH-02844
1mg2.277,00€5µg98,00€10µg158,00€20µg255,00€50µg385,00€100µg532,00€200µg822,00€500µg1.459,00€Complement C3 Protein, Mouse, Recombinant (His & SUMO)
Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:55.3 kDa (predicted)Ref: TM-TMPH-02604
1mg2.350,00€5µg106,00€10µg171,00€20µg276,00€50µg418,00€100µg566,00€200µg875,00€500µg1.554,00€C1RA Protein, Mouse, Recombinant (His & Myc)
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.Forma y color:Lyophilized PowderPeso molecular:85.7 kDa (predicted)Ref: TM-TMPH-02602
1mg2.350,00€5µg106,00€10µg171,00€20µg276,00€50µg418,00€100µg566,00€200µg875,00€500µg1.554,00€Complement C4-B Protein, Mouse, Recombinant (His)
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway.Forma y color:Lyophilized PowderPeso molecular:39.0 kDa (predicted)Ref: TM-TMPH-02605
1mg2.350,00€5µg106,00€10µg171,00€20µg276,00€50µg418,00€100µg566,00€200µg875,00€500µg1.554,00€C5AR1 Protein, Human, Recombinant (Cell-Free, His)
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.Pureza:90%Forma y color:Lyophilized PowderPeso molecular:40.7 kDa (predicted)C1QL1 Protein, Mouse, Recombinant (His)
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses.Forma y color:Lyophilized PowderPeso molecular:26.9 kDa (predicted)Complement C4-B Protein, Human, Recombinant (His & SUMO)
Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.Forma y color:Lyophilized PowderPeso molecular:49.1 kDa (predicted)Ref: TM-TMPH-01131
1mg1.700,00€5µg84,00€10µg120,00€20µg193,00€50µg290,00€100µg416,00€200µg631,00€500µg1.123,00€C1QL3 Protein, Mouse, Recombinant (His & Myc)
May regulate the number of excitatory synapses that are formed on hippocampus neurons.Forma y color:Lyophilized PowderPeso molecular:28.6 kDa (predicted)Complement C8b Protein, Human, Recombinant (His)
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane ofForma y color:Lyophilized PowderPeso molecular:67.0 kDa (predicted)Ref: TM-TMPH-01133
1mg2.350,00€5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€Complement C8a Protein, Human, Recombinant (His)
Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.Forma y color:Lyophilized PowderPeso molecular:65.8 kDa (predicted)Ref: TM-TMPH-01132
1mg1.932,00€5µg90,00€10µg144,00€20µg231,00€50µg349,00€100µg478,00€200µg724,00€500µg1.276,00€Complement factor B Protein, Mouse, Recombinant (His)
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb.Forma y color:Lyophilized PowderPeso molecular:87.0 kDa (predicted)Ref: TM-TMPH-02607
1mg2.350,00€5µg106,00€10µg171,00€20µg276,00€50µg418,00€100µg566,00€200µg875,00€500µg1.554,00€C1QA Protein, Mouse, Recombinant (E. coli, His)
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system.Pureza:98% - > 85% as determined by SDS-PAGEForma y color:Lyophilized PowderPeso molecular:29.1 kDa (predicted)Complement C5 Protein, Rat, Recombinant (His & Myc)
Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E.Forma y color:Lyophilized PowderPeso molecular:14.0 kDa (predicted)Ref: TM-TMPH-03270
1mg2.350,00€5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€Complement factor I Protein, Rat, Recombinant (His & Myc)
Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag.Forma y color:Lyophilized PowderPeso molecular:69.2 kDa (predicted)Ref: TM-TMPH-03273
5µg172,00€10µg285,00€20µg478,00€50µg888,00€100µg1.439,00€200µg1.625,00€500µg1.997,00€C1SB Protein, Mouse, Recombinant (His & Myc)
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system.Forma y color:Lyophilized PowderPeso molecular:82.4 kDa (predicted)Ref: TM-TMPH-02603
1mg2.350,00€5µg130,00€10µg211,00€20µg351,00€50µg520,00€100µg714,00€200µg1.027,00€500µg1.607,00€Empasiprubart
CAS:Empasiprubart (anti-C2 mAb) inhibits classical & lectin complement pathways upstream of C3, showing efficacy in autoimmune models.Pureza:95%Forma y color:LiquidPeso molecular:~150 kDaNRP1 antagonist 2
CAS:NRP1 antagonist 2 (Compound 1) is an NRP1 antagonist.Fórmula:C20H17ClN6OS2Forma y color:SolidPeso molecular:456.97C5aR-IN-2
CAS:C5aR-IN-2, a potent C5aR inhibitor, shows promise for researching inflammatory diseases.Fórmula:C36H40FN5O2Forma y color:SolidPeso molecular:593.73Isocyclosporin A
CAS:Isocyclosporin A is a rearranged degradation product. It is formed by acid treatment of cyclosporin A under aqueous and non-aqueous conditions.Fórmula:C62H111N11O12Forma y color:SolidPeso molecular:1202.61BCX 1470
CAS:BCX 1470 inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.Fórmula:C14H10N2O2S2Pureza:98%Forma y color:SolidPeso molecular:302.37
