
Derivados de Purinas y Pirimidinas
Las purinas tienen una estructura bicíclica, formada por un anillo de seis miembros fusionado con un anillo de cinco, ambos con átomos de nitrógeno en posiciones clave. Los derivados de purinas, como la adenina y la guanina, son fundamentales en la formación del ADN y ARN. Estos compuestos tienen aplicaciones terapéuticas en tratamientos contra el cáncer y enfermedades virales, al inhibir la replicación celular. Las pirimidinas, por otro lado, tienen una estructura monocíclica de seis miembros con dos átomos de nitrógeno. Sus derivados, como la citosina, timina y uracilo, también son componentes esenciales del ADN y ARN y se utilizan en la quimioterapia y tratamientos antivirales.
En CymitQuimica disponemos de derivados de purinas y pirimidinas para investigación en biología molecular, genómica y desarrollo de terapias innovadoras.
Se han encontrado 8888 productos de "Derivados de Purinas y Pirimidinas"
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Methotrexate
CAS:<p>Stability Hygroscopic<br>Applications A Folic acid antagonist. Used as a antineoplastic and antirheumatic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Freeman, M.V., J. Pharmacol. Exp. Ther., 122, 154 (1958), Weinblass, M.E., et al.: N. Engl. J. Med., 312, 818 (1985),<br></p>Fórmula:C20H22N8O5Forma y color:Yellow To Dark YellowPeso molecular:454.44(4-N-(Benzhydryloxycarbonyl)cytosine)-1-acetic acid
CAS:Pureza:98.0%Forma y color:SolidPeso molecular:379.37200927734375Thyroxine
CAS:Producto controlado<p>Applications Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.<br>References Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976); Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988); Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996); Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997);<br></p>Fórmula:C15H11I4NO4Forma y color:Off-WhitePeso molecular:776.87(6-Benzhydryloxycarbonylamino-purin-9-yl)-acetic acid
CAS:Pureza:97.0%Forma y color:SolidPeso molecular:403.398010253906255-[(1S)-1-(2-Chlorophenyl)-2-methoxy-2-oxoethyl]-6,7-dihydro-Thieno[3,2-c]pyridinium Bromide
CAS:Producto controladoFórmula:C16H15BrClNO2SForma y color:NeatPeso molecular:400.722-(5-amino-3-cyclopropyl-1H-pyrazol-1-yl)-5,6-dimethylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:245.28599548339844Ethyl-S-(+)-Clopidogrel Sulfate
CAS:Producto controlado<p>Stability Very Hygroscopic<br>Applications Ethyl-(S)-(+)-Clopidogrel Sulfate is an analogue of S-(+)-Clopidogrel Hydrogen Sulfate (C587250) which is used as an antithrombotic.<br>References Mills, D.C.B., et al.: Arterioscler. Thromb., 12, 430 (1992), Feuerstein, G., et al.: Exp. Opin. Invest. Drugs, 4, 425 (1995)<br></p>Fórmula:C17H20ClNO6S2Forma y color:White To Off-WhitePeso molecular:433.93N-(9-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide hydrate
CAS:Pureza:98+%Peso molecular:373.3689880371094Tenofovir Disoproxil Isopropoxycarbonyl
CAS:<p>Stability Hygroscopic<br>Applications Tenofovir Disoproxil derivative as antiviral and antitumor agent.<br></p>Fórmula:C23H36N5O12PForma y color:White SolidPeso molecular:605.534,6-Dihydroxypyrazolo[3,4-d]pyrimidine-13C,15N2
CAS:Producto controlado<p>Applications A labelled metabolite of Allopurinol.<br>References Marro, P., et al.: Brain Res., 650, 9 (1994), Abramov, A., et al.: J. Neurosci., 27, 1129 (2007), Day, R., et al.: Clin. Pharmacokinet., 46, 623 (2007),<br></p>Fórmula:CC4H415N2N2O2Forma y color:White To BeigePeso molecular:155.094-(3,4-dimethylphenyl)-6-(2-fluorophenyl)pyrimidin-2-amine
CAS:Pureza:95.0%Peso molecular:293.3450012207031Tenofovir Alafenamide-d5 (Diastereomers)
CAS:Producto controladoFórmula:C212H5H24N6O5PForma y color:NeatPeso molecular:481.50N-(2-Chloro-5-methoxypyrimidin-4-yl)-1H-indazol-6-amine
CAS:Pureza:98%Peso molecular:275.70001220703125Ref: 10-F538203
1gA consultar2gA consultar5gA consultar100mgA consultar250mgA consultar500mgA consultarTenofovir Phosphate Diammonia Salt, >90%
CAS:Producto controlado<p>Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.<br>References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>Fórmula:C9H21N7O7P2Pureza:>90%Forma y color:NeatPeso molecular:401.251-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:375.4070129394531Dihydro Caffeic Acid 3-O-β-D-Glucuronide Diammonium Salt
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Dihydro Caffeic Acid 3-O-β-D-Glucuronide is a glucuronide metabolite of Caffeic Acid (C080000).<br>References Clifford, M., et al.: J .Agric. Food Chem., 53, 3821 (2005), Lafay, S., et al.: J. Nutr., 136, 1192 (2006), Poquet, L., et al.: Drug Metab. Dispos., 36, 190 (2008)<br></p>Fórmula:C15H18O10•2NH3Forma y color:NeatPeso molecular:358.3021703N2-ISOBUTYRYL-2'-O-METHYL-GUANOSINE
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:367.361999511718752-(1-naphthyl)pyrimidine-5-carbaldehyde
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:234.25799560546875N'-Methyl-N,N-diphenylurea
CAS:<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>Fórmula:C14H14N2OForma y color:NeatPeso molecular:226.27Formaldehyde 2,4-Dinitrophenylhydrazone
CAS:<p>Stability Shock Sensitive<br>Applications Formaldehyde 2,4-Dinitrophenylhydrazone is a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde found in mainstream cigarette smoke.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010);<br></p>Fórmula:C7H6N4O4Forma y color:NeatPeso molecular:210.15N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide
CAS:<p>Applications N-(6-Amino-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetamide is an intermediate in synthesizing 5-Acetylamino-6-formylamino-3-methyluracil (A168210), which is a metabolite of Caffeine (C080100).<br>References Grant, D.M., et al.: Clin. Pharm. and Ther., 33, 591 (1983),<br></p>Fórmula:C7H10N4O3Forma y color:Off White SolidPeso molecular:198.185-Cyclopropyl-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-amine
CAS:Pureza:95.0%Peso molecular:360.39599609375Zolmitriptan-d6 (Major)
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A Serotonin 5HTID-receptor agonist.<br>References Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)<br></p>Fórmula:C16H15D6N3O2Forma y color:NeatPeso molecular:293.39Ref: 10-F863238
1g33,00€5g99,00€10g156,00€25g293,00€100g751,00€10mg17,00€50mg17,00€100mg17,00€250mgA consultar2-(5-amino-3-phenyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one
CAS:Pureza:95.0%Peso molecular:267.29199218759-Propenyladenine
CAS:<p>Impurity Tenofovir Disoproxil USP Related Compound B<br>Applications 9-Propenyladenine (Tenofovir Disoproxil USP Related Compound B) is an N-substituted purine and an impurity of Tenofovir (T018500). Tenofovir Disoproxil Related Compound B ((E)-9-(Prop-1-enyl)-9H-purin-6-amine).<br>References Montgomery, J.A. et al.: J. Org. Chem., 30, 3235 (1965);<br></p>Fórmula:C8H9N5Forma y color:White To Light YellowPeso molecular:175.191-(1,3-Dioxolan-2-ylmethyl)-N-methyl-4-(methylamino)-1H-imidazole-5-carboxamide
CAS:Producto controladoFórmula:C10H16N4O3Forma y color:NeatPeso molecular:240.26N-[2-[[[[1-Methyl-5-[(triphenylmethyl)amino]-1H-pyrazol-4-yl]amino]carbonyl]amino]ethyl]carbamic acid tert-butyl ester
CAS:Pureza:97%Peso molecular:540.6680297851562Ref: 10-F863727
1g16,00€5g45,00€10g87,00€1kg2.694,00€25g196,00€50g287,00€100g507,00€250g994,00€500g1.580,00€250mgA consultarUric Acid
CAS:<p>Applications Uric Acid is a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006);<br></p>Fórmula:C5H4N4O3Forma y color:NeatPeso molecular:168.11Methyl 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methylthiazole-5-carboxylate
CAS:Producto controladoFórmula:C17H18N2O3SForma y color:NeatPeso molecular:330.42-(4-Chlorophenyl)amino-4-phenylpyrimidine
CAS:Pureza:95.0%Forma y color:Solid, No data available.Peso molecular:281.7399902343754-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid
CAS:<p>4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid is a drug with low bioavailability. It is used to treat leishmaniasis, an infection caused by the parasite Leishmania. 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic acid inhibits the synthesis of folic acid by blocking the enzyme dihydrofolate reductase in the bacteria. This drug also has been shown to be effective against autoimmune diseases and inflammatory bowel disease. The terminal half-life of 4-[(2,4-diamino6 pteridinyl)methyl]methylamino benzoic acid is approximately 5 hours and it can be detected in urine for up to 12 hours after administration.</p>Fórmula:C15H15N7O2Pureza:(1H-Nmr) Min. 95 Area-%Forma y color:Brown Yellow PowderPeso molecular:325.33 g/molEthyl 3-aminopyrazole-4-carboxylate
CAS:<p>Ethyl 3-aminopyrazole-4-carboxylate is an anticancer drug that inhibits the growth of cancer cells by inhibiting protein synthesis. It has been shown to inhibit the activity of dpp-iv and pde5, which are enzymes involved in cellular proliferation. Ethyl 3-aminopyrazole-4-carboxylate has also been shown to have antiinflammatory properties, which may be due to inhibition of prostaglandin synthesis. <br>Ethyl 3-aminopyrazole-4-carboxylate is a multinuclear compound that reacts with nitrogen atoms from the pyrazoles to form a stable molecule. Dimethylformamide is used as a solvent for this reaction. The synthesis of ethyl 3-aminopyrazole-4-carboxylate starts with acetylation, which converts the carboxylic acid group into an acetic acid group. The acetic acid group reacts with ammonia and hydrogen cyan</p>Fórmula:C6H9N3O2Pureza:Min. 95%Forma y color:PowderPeso molecular:155.16 g/molMemantine impurity IV
CAS:<p>Memantine impurity IV is a hydrolysis product of memantine. It appears as a white to off-white powder and has a molecular weight of 198.1 g/mol. Memantine impurity IV is an intermediate in the production of memantine and is therefore not used for any other purpose. The compound contains hydroxy groups, hydroxy, alcohols, and bridgehead groups which are efficient at hydrolyzing to form amino acids.</p>Fórmula:C12H21NO·HClPureza:Min. 95%Forma y color:White PowderPeso molecular:231.76 g/molN-Acetylmemantine
CAS:<p>N-Acetylmemantine is a drug that inhibits the activity of acetylcholinesterase in the brain. It has been shown to inhibit cancer cell growth and induce apoptosis, as well as inhibit the reaction of hydrolysis of acetonitrile with hydrochloric acid in an organic solvent. N-Acetylmemantine is synthesized by heating ethylene in the presence of hydrochloric acid. The synthesis yields a white solid that consists mainly of N-acetylmethamphetamine. This drug interacts with cellular membranes, which may be due to its ability to react with cholesterol or phospholipids. The interaction leads to changes in membrane permeability, which can result in apoptosis.</p>Fórmula:C14H23NOPureza:Min. 95%Forma y color:White PowderPeso molecular:221.34 g/molTenofovir disoproxil related compound B
CAS:<p>Tenofovir disoproxil related compound B is a peptidyl prodrug that is metabolized by esterases to tenofovir. It has been shown to be an effective agent against Mycobacterium tuberculosis and other bacterial species. Tenofovir disoproxil related compound B was also found to inhibit protein synthesis in Mycobacterium avium and Mycobacterium smegmatis, but not in Escherichia coli. This drug binds to the ribosome's 30S subunit, which blocks the binding of aminoacyl-tRNA and prevents the formation of peptide bonds. The mechanism of action for this drug is similar to that of the antibiotic erythromycin.</p>Fórmula:C8H9N5Pureza:Min. 98 Area-%Peso molecular:175.19 g/molMethotrexate dimethylamide
CAS:<p>Methotrexate dimethylamide is a research and development impurity standard with high purity. It is a synthetic drug product that can be custom synthesized to meet the needs of the customer. Methotrexate dimethylamide has been used as an analytical standard for HPLC analysis and as a natural metabolite in metabolism studies. This compound is also known as 71074-44-7, CAS No. 71074-44-7, or Metabolite.</p>Fórmula:C22H27N9O4Pureza:Min. 95%Peso molecular:481.51 g/molAllopurinol impurity C
CAS:<p>Allopurinol impurity C is a product of the reaction between allopurinol and n-butyl alcohol, which occurs in the presence of sodium hydroxide solution and dimethylformamide. The reaction condition is heated to reflux for 12 hours, after which the mixture is filtered and concentrated under reduced pressure. The resultant crude product is purified by column chromatography with ethyl acetate and then recrystallized from methanol. The synthesis scheme can be found in Figure 1.</p>Fórmula:C6H6N6OPureza:Min. 95%Forma y color:Slightly Yellow PowderPeso molecular:178.15 g/molN-(5-Aminopentyl) methotrexate amide
CAS:<p>N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.</p>Fórmula:C25H34N10O4Pureza:Min. 95%Forma y color:Yellow PowderPeso molecular:538.6 g/molPemetrexed related impurity 2
<p>Pemetrexed related impurity 2 is a drug product that is an analytical impurity found in the metabolite of pemetrexed. It has been shown to be naturally occurring and is not toxic at high doses. This impurity has been synthesized as an impurity standard for HPLC. Pemetrexed related impurity 2 is used in research and development studies for drug development, such as pharmacopoeia testing for high purity standards.</p>Fórmula:C20H21N5O8Pureza:Min. 95%Peso molecular:459.41 g/mol4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester
CAS:<p>4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a useful intermediate in the synthesis of 7''-deazaguanine, which is a key building block in the synthesis of DNA. 4-[2'-(7''-Deazaguanine)ethyl]benzoic acid N-hydroxysuccinimide ester is a versatile building block that can be used in the synthesis of complex compounds. It has been shown to react with amines, sulfonyl chlorides, and epoxides to form amides, sulfonamides, and epoxy amines respectively. The CAS number for this compound is 204257-65-8.</p>Fórmula:C19H17N5O5Pureza:Min. 95%Peso molecular:395.37 g/molTenofovir isoproxil monoester
CAS:<p>Tenofovir isoproxil monoester is a prodrug of Tenofovir, which is an antiviral drug. Tenofovir prevents the growth of HIV by interfering with the synthesis of viral DNA. The process development stage involves converting Tenofovir to its disoproxil monoester form, which has been shown to have greater antiviral activity than Tenofovir alone. This conversion process involves condensing one molecule of fumarate with two molecules of tenofovir, forming tenofovir disoproxil fumarate (TFD). TFD can be converted back to Tenofovir using hydrolysis and hydrogenation. Impurities in TFD include isopropyl tenofovir and unidentified impurities that are not present in the parent drug, tenofovir. Tenofovir Disoproxil Fumarate was also shown to be more potent than TFD and is undergoing clinical trials for</p>Fórmula:C14H22N5O7PPureza:Min. 97 Area-%Forma y color:White/Off-White SolidPeso molecular:403.33 g/mol3-Amino-4-carbamoylpyrazole hemisulfate
CAS:<p>3-Amino-4-carbamoylpyrazole hemisulfate is a white to yellowish crystalline powder that is soluble in water and methanol. It is a condensation product of allopurinol and ethyl orthoformate with a molecular weight of 312.4. 3-Amino-4-carbamoylpyrazole hemisulfate can be used as an anti-inflammatory agent, but it has not been approved for medical use in the United States.</p>Fórmula:C4H6N4OH2O4SPureza:Min. 95%Forma y color:White PowderPeso molecular:175.16 g/mol4-(Pyrimidin-2-yl)benzaldehyde
CAS:Fórmula:C11H8N2OPureza:98%Forma y color:Solid, No data available.Peso molecular:184.1982,6-Diamino-4-hydroxypyrimidine
CAS:Fórmula:C4H6N4OPureza:97%Forma y color:Beige powderPeso molecular:126.119Methyl 2-aminopyrimidine-5-carboxylate
CAS:Fórmula:C6H7N3O2Pureza:97%Forma y color:SolidPeso molecular:153.1412-Chloro-4-methoxy-6-methyl-pyrimidine
CAS:Fórmula:C6H7ClN2OPureza:96%Forma y color:SolidPeso molecular:158.591-((2R,4S,5R)-4-((tert-Butyldimethylsilyl)oxy)-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS:Fórmula:C16H28N2O5SiPureza:97%Forma y color:SolidPeso molecular:356.4943-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione
CAS:Pureza:98%Peso molecular:401.17999271-(3-Hydroxypropyl)-3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
CAS:Pureza:98%Peso molecular:238.2469942-Amino-4,6-dimethylpyrimidine
CAS:Fórmula:C6H9N3Pureza:97%Forma y color:Solid, White to slightly pale yellow crystal powderPeso molecular:123.159Methyl 2-aminopyrimidine-4-carboxylate
CAS:Fórmula:C6H7N3O2Pureza:97%Forma y color:SolidPeso molecular:153.1419-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-ol
CAS:Fórmula:C10H12N4O4Pureza:96%Forma y color:SolidPeso molecular:252.232-Bromo-5-fluoropyrimidine
CAS:Fórmula:C4H2BrFN2Pureza:95%Forma y color:Off-white solidPeso molecular:176.976N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine
CAS:Pureza:97%Peso molecular:787.98901371H-Purine-2,6(3H,7H)-dione
CAS:Fórmula:C5H4N4O2Pureza:95%Forma y color:Crystalline PowderPeso molecular:152.1131-[(2R,3S,4R,5R)-3,4-bis(benzoyloxy)-2-[(benzoyloxy)methyl]-5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]triaz-2-yn-2-ium-1-ide
CAS:Pureza:95%Peso molecular:597.539978tert-Butyl (3-((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)amino)propyl)carbamate
CAS:Pureza:95%Peso molecular:378.282,4-Dihydroxy-6-methylpyrimidine
CAS:Fórmula:C5H6N2O2Pureza:95%Forma y color:SolidPeso molecular:126.1158-Bromo-1H-purine-2,6(3H,7H)-dione
CAS:Fórmula:C5H3BrN4O2Pureza:97%Forma y color:SolidPeso molecular:231.009


