Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65541 productos de "Derivados de Quinazolina y Quinolina"
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4'-[(1,7'-Dimethyl-2'-propyl[2,5'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic Acid
CAS:Producto controlado<p>Impurity Telmisartan EP Impurity B; Timolol USP Related Compound B<br>Applications 4’-Desmethyl-7’-methyl Telmisartan (Telmisartan EP Impurity B; Timolol USP Related Compound B) is an impurity of Telmisartan (T017000), an angiotensin II receptor antagonist.<br></p>Fórmula:C33H30N4O2Forma y color:Off-WhitePeso molecular:514.62Resiquimod-d5
CAS:Producto controlado<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>Fórmula:C17H17D5N4O2Forma y color:NeatPeso molecular:319.412'-Hydroxy-3'-methoxyacetophenone
CAS:Producto controlado<p>Applications 2'-Hydroxy-3'-methoxyacetophenone, is an intermediate used for he synthesis of various chemical compounds. It can be used for the synthesis of 4'-Hydroxy-3-methoxyflavones with potent antipicornavirus activity.<br>References Nadine, d. M., et al.: J. Med. Chem., 34, 736 (1991);<br></p>Fórmula:C9H10O3Forma y color:NeatPeso molecular:166.18(S)-Isotimolol
CAS:Producto controlado<p>Applications An isomer of the antiarrhythmic, antiglaucoma agent Timolol (T443700).<br>References Marini, R.D. et al.: Anal. Chim. Acta, 531, 131 (2005);<br></p>Fórmula:C13H24N4O3SForma y color:WhitePeso molecular:316.42Pimozide N-Oxide
CAS:<p>Applications Pimozide N-Oxide is an impurity of Pimozide (P447800) with hERG inhibitory activity. Pimozide impurity E.<br></p>Fórmula:C28H29F2N3O2Forma y color:Off White PowderPeso molecular:477.542-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate
CAS:<p>Applications 2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.<br>References Francesco, C., et al.: Eur. J. Org. Chem., 27, 6011 (2015)<br></p>Fórmula:C11H13F3O5SForma y color:NeatPeso molecular:314.278Gabapentin-d10
CAS:Producto controlado<p>Applications Gabapentin-d10 is the labelled analogue of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C92H10H7NO2Forma y color:White To Off-WhitePeso molecular:181.304-Defluoro-2-fluoro Haloperidol
CAS:<p>Applications 4-Defluoro-2-fluoro Haloperidol is a positional isomer and impurity of the antipsychotic agent Haloperidol (H103700).<br></p>Fórmula:C21H23ClFNO2Forma y color:NeatPeso molecular:375.86Ribociclib nitroso impurity 1
Producto controladoFórmula:C23H29N9O2Forma y color:NeatPeso molecular:419.495Lisinopril (S,S,R)-Diketopiperazine (~90%)
CAS:<p>Impurity Lisinopril EP Impurity D<br>Stability Hygroscopic<br>Applications Lisinopril (S,S,R)-Diketopiperazine (Lisinopril EP Impurity D) is an impurity of Lisinopril (L468985), an orally active angiotensin-converting enzyme (ACE) inhibitor (1).<br>References 1. Goa, K. et al.: Drugs. 1996 Oct;52(4):564-88.<br></p>Fórmula:C21H29N3O4Pureza:~90%Forma y color:White To Off-WhitePeso molecular:387.47N-Butyl-N-methylnitrosamine (1 mg/mL in Methanol)
CAS:Fórmula:C5H12N2OForma y color:Single SolutionPeso molecular:116.16Dolutegravir intermediate-1
CAS:Producto controladoFórmula:C13H17NO8Forma y color:Light YellowPeso molecular:315.282-(2-Aminoethoxy)anisole
CAS:Producto controlado<p>Applications 2-(2-Aminoethoxy)anisole is used as an additive to vinylphosphonic acid esters and acrylonitrile forming compounds displaying hypotensive activity. An impurity from the process of Carvedilol (C184625)<br>References Reznik, V. et al.: Russ. Chem. Bull., 48, 979, (1999); Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990), Packer, M., et al.: N. Engl. J. Med., 334, 1349 (1996),<br></p>Fórmula:C9H13NO2Forma y color:NeatPeso molecular:167.204'-Ethoxyacetophenone
CAS:<p>Applications 4'-Ethoxyacetophenone, is an acetophenone derivative that can be used as an antibacterial agent. It is a reagent for plymerization. It can also be used as a flavoring agent in fabricating cigarettes with flavored filter tips.<br>References Sivakumar, P., et al.: Chem. Bio. Drug Design, 72, 303 (2008); Mathis, D. E., Beitraege zur Tabakforschung Int., 12, 1 (1983);<br></p>Fórmula:C10H12O2Forma y color:White To Off-WhitePeso molecular:164.20Anastrozole Mono Acid
CAS:<p>Impurity Anastrozole Monoacid Impurity<br>Applications Anastrozole Mono Acid is an impurity of Anastrozole (A637435), an aromatase enzyme inhibitor and antineoplastic agent. Anastrozole Monoacid Impurity<br>References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)<br></p>Fórmula:C17H20N4O2Forma y color:Off-WhitePeso molecular:312.375,5-Diphenyl Hydantoin
CAS:<p>Applications Diphenyl Hydantoin is an anticonvulsant agent that suppresses abnormal brain activity associated with seizure. It is used to treat ulcers, epidermolysis bullosa, chorea, Parkinson’s syndrome, trigeminal neuralgia, acute alcoholism, and inflammatory conditions (1,2).<br>References (1) Kim, S. H., et al.: Birth Defects Res B Dev Reprod Toxicol. 95, 337 (2012)(2) Younes, N., et al.: Dermatol Online J. 12, 5 (2006)<br></p>Fórmula:C15H12N2O2Forma y color:WhitePeso molecular:252.27N-Phenoxycarbonylparoxetine
CAS:Producto controlado<p>Applications N-Phenoxycarbonylparoxetine is an impurity of Paroxetine (P205750), a selective serotonin reuptake inhibitor. Used as an antidepressant.<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>Fórmula:C26H24FNO5Forma y color:NeatPeso molecular:449.47N-Boc-Sitagliptin
CAS:Producto controlado<p>Applications N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes.<br>References Aschner, P., et al.: Diabetes Care, 29, 2632 (2006); Charbonnel, B., et al.: Diabetes Care, 29, 2638 (2006)<br></p>Fórmula:C21H23F6N5O3Forma y color:NeatPeso molecular:507.43Robenidine-d8
CAS:Producto controlado<p>Applications Labelled Robenidine (R639000). Robenidine is used as a coccidiostat.<br>References Kantor, et al.: Science, 373, 168 (1970), Wong, et al.: Biochem. Biophys. Res. Commun., 46, 621 (1972)<br></p>Fórmula:C15H5D8Cl2N5Forma y color:YellowPeso molecular:342.25aR-Brivaracetam
CAS:Producto controlado<p>Applications αR-Brivaracetam acts as a reagent for the preparation of 2-Oxo-1-pyrrolidine derivatives and their anticonvulsants activity. Also, is an impurity of Brivaracetam (B677645), a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Differding, E., et al.: PCT Int. Appl. (2001), WO 2001062726 A2 20010830; Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007); Malawska, B., et al.:, Curr. Opin. Investig. Drugs, 6(7), 740 (2005);<br></p>Fórmula:C11H20N2O2Forma y color:NeatPeso molecular:212.29Sitagliptin Triazecine Analog
CAS:Producto controlado<p>Impurity Sitagliptin Tablets EP Impurity FP-B<br>Applications Sitagliptin Triazecine Analog is related to the family of Sitagliptin compounds which has recently been approved for the therapy of type II diabetes.<br>References Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)<br></p>Fórmula:C16H13F6N5O2Forma y color:NeatPeso molecular:421.30Quizalofop
CAS:<p> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Fórmula:C17H13ClN2O4Forma y color:Off-White To Light YellowPeso molecular:344.752-De(dimethylamino)-2-vinyl Dimetindene
CAS:<p>Applications Dimetindene derivative, a histaminic H1 receptor antagonist.<br></p>Fórmula:C18H17NForma y color:Light YellowPeso molecular:247.3343Reserpine
CAS:Producto controlado<p>Applications An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.<br>References Muller, J.M., et al.: Experientia, 8, 338 (1952), Schirmer, R.E., et al.: Anal. Profiles Drug Subs., 4, 384 (1975), Diener, R.M., et al.: Toxicol. Pathol., 8, 1 (1980),<br></p>Fórmula:C33H40N2O9Forma y color:Off-WhitePeso molecular:608.68Desmethyl Amisulpride Hydrobromide
CAS:Producto controladoFórmula:C16H26BrN3O4SForma y color:NeatPeso molecular:436.36(2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]
CAS:<p>Applications (2R,3S)-rel-Nadolol-N-[(2R,3S)-rel-Nadolol-de(N-tert-butyl)]is an impurity of Nadolol (N201050), a β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977); Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978); Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980)<br></p>Fórmula:C30H43NO8Forma y color:White SolidPeso molecular:545.66cis-Montelukast
CAS:Producto controlado<p>Impurity Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast Cis-Isomer<br>Stability Light Sensitive<br>Applications cis-Montelukast (Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast cis Isomer) is a cis geometric isomer of Montelukast. An impurity of Montelukast.<br>References Schoors, D., et al.: Br. J. Clin. Pharmacol., 40, 277 (1995), Amin, R., et al.: J. Pharm. Biomed. Anal., 13, 155 (1995), Reiss, T., et al.: J. Allergy Clin. Immunol., 98, 528 (1996),<br></p>Fórmula:C35H36ClNO3SForma y color:Light YellowPeso molecular:586.184’-Bromomethyl-2-cyanobiphenyl
CAS:Producto controlado<p>Impurity Irbesartan Bromo Nitrile Impurity<br>Applications Halogenated benzonitrile used in protein-binding studies of quinoxaline angiotensin II receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References KIm, Y.S., et al.: Bioorg. Med. Chem., 3, 2667 (1993),<br></p>Fórmula:C14H10BrNForma y color:NeatPeso molecular:272.14MDV 3100-d6 (Enzalutamide-d6)
CAS:Producto controlado<p>Applications Isotope labelled MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br></p>Fórmula:C21H10D6F4N4O2SForma y color:NeatPeso molecular:470.486-Hydroxy Chlorzoxazone-d2
CAS:Producto controlado<p>Applications 6-Hydroxy Chlorzoxazone-d2 is a labeled analogue of 6-Hydroxy Chlorzoxazone (H825120), A major metabolite of chlorzoxazone and formed by the actions of cytochrome P450IIE1.<br>References Twele, et al.: Arzneim.-Forsch., 32, 759 (1982); Peter, et al.: che. Res. Toxicol., 3, 566 (1990)<br></p>Fórmula:C7H2D2ClNO3Forma y color:White To BrownPeso molecular:187.58Niclosamide Ethanolamine Salt
CAS:<p>Applications Niclosamide Ethanolamine Salt is an ethanolamine salt of Niclosamide (N395500), which is used as an anthelmintic drug (Cestodes)<br>References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),<br></p>Fórmula:C13H8Cl2N2O4·C2H7NOForma y color:Dark YellowPeso molecular:388.20Dehydronitrosonisoldipine
CAS:Producto controlado<p>Impurity Nisoldipine<br>Applications Dehydronitrosonisoldipine is an impurity of Nisoldipine (N489125). Nisoldipine is a dihydropyridine calcium channel blocker and it is antihypertensive and antianginal.<br>References Kazda, S., et al.: Arzneimittel-Forsch., 30, 2144 (1980); Pasanisi, F., et al.: Eur. J. Clin. Pharmacol., 29, 21 (1985); Lam, J., et al.: J. Am. Col. Cardiol., 6, 447 (1985)<br></p>Fórmula:C20H22N2O5Forma y color:NeatPeso molecular:370.4Imiquimod
CAS:Producto controlado<p>Applications An immune response modifier. It stimulates the production of interferon-a.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998)<br></p>Fórmula:C14H16N4Forma y color:White To Off-WhitePeso molecular:240.30Cinitapride Tartrate
CAS:<p>Applications Cinitapride Tartrate is the salt analogue of Cinitapride (C441990), a novel prokinetic benzamide-stimulating gastrointestinal motility agent and antiucer agent. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.<br>References Alarcon de la Lastra, C. et al.: Pharmacol, 54, 193 (1997); Robert, M. et al.: Drug Metab. Disp., 35, 1149 (2007); Alarcon de la Lastra, C. et al.: Inflam. Res., 47, 131 (1998)<br></p>Fórmula:C21H30N4O4·C4H6O6Forma y color:NeatPeso molecular:552.57Bupivacaine-d9 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Bupivacaine (B689560). Sodium channel blocker, local anesthetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, T.D., et al.: Anal. Profiles Drug Subs., 19, 59 (1990), McClellan, K.J., et al.: Drugs, 56, 355 (1998),<br></p>Fórmula:C182H9H19N2O·ClHForma y color:NeatPeso molecular:333.94Loxapine-d8 Hydrochloride (Major)
CAS:Producto controladoFórmula:C18H10D8ClN3O·xHClForma y color:White To Off-WhitePeso molecular:372.32Olanzapine
CAS:Producto controlado<p>Applications Olanzapine is a serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic. Neuroprotective product.<br>References Moore, N.A., et al.: Curr. Opin Invest. Drugs, 2, 281 (1993), Baldwin, D.S. and Montgomery, S.A.: Int. Clin. Psychopharmacol., 10, 239 (1995), Tohen, M., et al.: Am. J. Psychiatry, 156, 702 (1999)<br></p>Fórmula:C17H20N4SForma y color:Light Yellow CrystallinePeso molecular:312.43Everolimus
CAS:Producto controlado<p>Impurity Everolimus EP Impurity C<br>Stability Hygroscopic<br>Applications Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.<br>References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),<br></p>Fórmula:C53H83NO14Pureza:~90%Forma y color:NeatPeso molecular:958.222-Methoxy Phenothiazine
CAS:<p>Applications An impurity of Methotrimeprazine (M260785).A derivative of Phenothiazine (P318040) exhibits tuberculostatic activity.<br>References Waisser, K., et al.: Folia. Pharm. Univ. Carol., 18, 41 (1995)<br></p>Fórmula:C13H11NOSForma y color:Grey To BrownPeso molecular:229.30Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate
CAS:<p>Applications Methyl 2-Methyl-6-(3-nitrophenyl)-4-oxo-2-cyclohexene-1-carboxylate is a nicardipine impurity. Also, it is derived from Methyl Acetoacetate (O848425), which is a chemical reagent used in the synthesis of pharmaceuticals. It participates in the Biginelli reaction, forming molecules including dihydropyrimidinones.<br>References Vaghela, B. K., et al.: J. Liq. Chromatogr. Related Technol., 36, 2166-2181 (2013);<br></p>Fórmula:C15H15NO5·C16H17NO5Forma y color:NeatPeso molecular:592.59Afatinib-d6
CAS:Producto controladoFórmula:C24H19D6ClFN5O3Forma y color:Light Yellow SolidPeso molecular:491.98MDV 3100 (Enzalutamide)
CAS:Producto controlado<p>Applications MDV 3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. MDV 3100 has also been shown to induce tumor cell apoptosis, and has no agonist activity. MDV 3100 is a candidate for the treatment of castration-resistant prostate cancer.<br>References Scher, H.I. et al.: Lancet, 375, 1437 (2010); Bellmunt, J. et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C.J. et al.: J. Clin. Oncol., 29, 3651 (2011);<br></p>Fórmula:C21H16F4N4O2SForma y color:WhitePeso molecular:464.44Altretamine
CAS:Producto controlado<p>Applications An antitumor agent which also acts as a chemosterilant for male houseflies and other insects. Antineoplastic.<br>References Chang, S.C., et al.: Science, 144, 57 (1964), Ames, M.M., et al.: Cancer Res., 39, 5016 (1979), D’Incalci, M., et al.: Br. J. Cancer, 41, 630 (1980),<br></p>Fórmula:C9H18N6Forma y color:White Crystalline PowderPeso molecular:210.28Trimetazidine Dihydrochloride
CAS:Producto controlado<p>Applications Coronary vasodilator. Antianginal.<br>References Fujita, et al.: Jpn. J. Pharmacol., 17, 19 (1967), Harpey, C., et al.: Cardiovasc. Drug Rev., 6, 292 (1989),<br></p>Fórmula:C14H22N2O3·2ClHForma y color:Off WhitePeso molecular:339.26Tilidine Impurity D Hydrochloride
CAS:Producto controlado<p>Applications Tilidine Impurity D Hydrochloride is an imourity of Tilidine, which is a controlled substance (opiate). Analgesic. It is used in clinical trial in comparison with Nefopam. Tilidine is one of the most widely used narcotics in Germany and Belgium.<br>References Vollmer, K.-O., et al.: Arzneim.-Forsch., 20, 990 (1970), Abeloos, J., et al.: Acta Anaesthesiol. Belg., 34, 283 (1983), Van Cauwenberge, H., et al.: Int. J. Clin. Pharmacol. Res., 12, 1 (1992),<br></p>Fórmula:C13H19NO2·ClHForma y color:NeatPeso molecular:257.76Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone
CAS:Producto controlado<p>Applications Bis[(1S)-3,4-dihydro-1-phenyl-2(1H)-isoquinolinyl]-methanone is a possible impurity of solifenacin (S676700) which is a muscarinic M3 receptor antagoinst. Solifenacin is used in treatment of urinary incontinence.<br>References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002); Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004); Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004); Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005); Habb, F., et al.: Eur. Urol. 47, 376 (2005); Payne, C.K., et al.: Drugs, 66, 175 (2006)<br></p>Fórmula:C31H28N2OForma y color:NeatPeso molecular:444.57
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