Derivados de Quinazolina y Quinolina
Las quinazolinas y quinolinas son compuestos heterocíclicos nitrogenados con estructuras aromáticas que desempeñan un papel clave en la síntesis de fármacos con actividad anticancerígena, antimicrobiana y antiinflamatoria. Sus derivados presentan modificaciones estructurales que optimizan su biodisponibilidad y selectividad, lo que permite el desarrollo de nuevos principios activos para diversas aplicaciones terapéuticas. Estos compuestos se utilizan en la fabricación de APIs destinados al tratamiento de cáncer, infecciones, enfermedades neurodegenerativas y cardiovasculares. Además, los derivados de quinazolina y quinolina son esenciales en la investigación de inhibidores enzimáticos y en el diseño de moléculas bioactivas innovadoras. En CymitQuimica disponemos de derivados de quinazolina y quinolina de alta pureza para aplicaciones en síntesis química, desarrollo farmacéutico y biotecnología.
Se han encontrado 65562 productos de "Derivados de Quinazolina y Quinolina"
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4-(thiophene-2-carbonyl)-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid
CAS:Pureza:95.0%Peso molecular:295.35000610351566-Chloro-2,3-dimethylpyridine
CAS:Fórmula:C7H8ClNPureza:98%Forma y color:Solid, Low Melting SolidPeso molecular:141.64-Hydroxybenzaldehyde
CAS:Producto controlado<p>Impurity Bisoprolol EP Impurity S<br>Stability Hygroscopic<br>Applications 4-Hydroxybenzaldehyde (Bisoprolol EP Impurity S) maintains bactericidal activity when tested against certain bacteria strains. It also displays antioxidant potential when analyzed through assay.<br>References Friedman, M. et al.: J. Food. Prot., 66, 1811 (2003); Liu, L. et al.: Chem. Nat. Comp., 48, 785 (2012);<br></p>Fórmula:C7H6O2Forma y color:BeigePeso molecular:122.12(Z)-Thiothixene-d8
CAS:Producto controladoFórmula:C23H21D8N3O2S2Forma y color:NeatPeso molecular:451.674-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride
CAS:Producto controlado<p>Impurity Paroxetine EP Impurity G<br>Applications 4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine Hydrochloride (Paroxetine EP Impurity G) is the active metabolite of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (M325910), N-Methyl-4-phenylpyridinium (MPP+), selectively destroys the dopaminergic neurons and induces the symptoms of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gerlach, M., et al.: Eur. J. Pharmacol., 208, 273 (1991), Tipton, K., et al.: J. Neurochem., 61, 1191 (1993), Wimalasena, D., et al.: J. Biol. Chem., 279, 15298 (2004),<br></p>Fórmula:C12H14FN·ClHForma y color:Light YellowPeso molecular:227.714-methoxy-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Pureza:95.0%Peso molecular:271.33999633789063-Aminopiperidine-2,6-dione Hydrochloride
CAS:Producto controlado<p>Applications 3-Aminopiperidine-2,6-dione hydrochloride is a reagent for preparing lenalidomide that can induce ubiquitination and degradation of CK1α in del(5q) MDS. It can also be used to prepare phthalimide conjugates that can promote ligand-dependent target protein degradation.<br>References Kronke, J., et al.: Nature 523, 183 (2015); Liu C., et al.: Faming Zhuanli Shenqing CN 105348257 A 20160224 (2016); Rao, R., et al. : PCT Int. Appl. WO 2016024286 A2 20160218 (2016)<br></p>Fórmula:C5H8N2O2·ClHForma y color:Off-WhitePeso molecular:164.590Nortilidine-d3 Hydrochloride
CAS:Producto controladoFórmula:C162H3H18NO2·ClHForma y color:NeatPeso molecular:298.82N-Boc-N-deshydroxyethyl Dasatinib
CAS:Producto controlado<p>Applications N-Boc-N-deshydroxyethyl Dasatinib (cas# 1159977-13-5) is a compound useful in organic synthesis. It is a COVID19-related research product.<br></p>Fórmula:C25H30ClN7O3SForma y color:Off White To Light YellowPeso molecular:544.07Isradipine
CAS:Producto controlado<p>Applications Isradipine is a dihydropyridine calcium channel blocker. Antihypertensive and antianginal.<br>References Nelson, E.B., et al.: Clin. Pharmacol. Ther., 40, 694 (1986); Hof, R.P., et al.: J. Cardiovasc. Pharmacol., 8, 221 (1986);<br></p>Fórmula:C19H21N3O5Forma y color:NeatPeso molecular:371.39Ethyl 5-(4-chlorophenoxy)-1-cyano-4-hydroxyisoquinoline-3-carboxylate
CAS:Pureza:techPeso molecular:368.76998901367195,5-Diphenyl Hydantoin Sodium
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications 5,5-Diphenyl Hydantoin Sodium salt reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na+, K+, and Ca2+ channels.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faucette, S., et al.: J. Pharmacol. Exp. Ther., 320, 72 (2007), Guo, D., et al.: J. Biol. Chem., 282, 36766 (2007), Merrell, M., et al.: Drug Metab. Dispos., 36, 1716 (2008),<br></p>Fórmula:C15H11N2O2·NaForma y color:NeatPeso molecular:274.25Amoxapine-d8
CAS:Producto controladoFórmula:C17H8D8ClN3OForma y color:Off White SolidPeso molecular:321.83AR-C133913XX
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications AR-C133913XX is an metabolte of Ticagrelor (T437700) which is the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004); Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007); Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>Fórmula:C14H22N6O4SForma y color:NeatPeso molecular:370.43[N(Z)]-N-(3,5-Dimethyl-2(3H)-thiazolylidene)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide
CAS:<p>Impurity Meloxicam EP Impurity C<br>Applications [N(Z)]-N-(3,5-Dimethyl-2(3H)-thiazolylidene)-4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide (Meloxicam EP Impurity C) is an impurity of Meloxicam (M216100), a preferential cyclooxygenase (COX-2) inhibitor.<br>References Volk, B., et al.: Org. Proc. Res. Develop., 15, 339 (2011);<br></p>Fórmula:C15H15N3O4S2Forma y color:Light YellowPeso molecular:365.427Celiprolol-d9 Hydrochloride
CAS:Producto controlado<p>Applications Labelled Celiprolol. Cardioselective β1-adrenergic blocker. Antihypertensive, antianginal.<br>References Mazzo, D.J., et al.: Anal. Profiles Drug Subs., 20, 237 (1991), Meininger, C., et al.: Biochem. J., 349, 353 (2000), Ruan, H., et al.: Diabetes, 51, 1319 (2002), Liao, Y., et al.: Circulation, 110, 692 (2004),<br></p>Fórmula:C20H25D9ClN3O4Forma y color:NeatPeso molecular:425.012-[[[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl ]methyl]thio]-1H-benzimidazole
CAS:Pureza:95.0%Forma y color:SolidPeso molecular:343.45001220703125Gabapentin-d6 Hydrochloride
CAS:Producto controlado<p>Applications Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.<br>References Vollmer, K.O. et al.: Arzneim.-Forsch., 36, 830 (1986); Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>Fórmula:C9H11D6NO2·HClForma y color:NeatPeso molecular:213.73Desmethyl Mirtazapine-d6 Dihydrochloride
CAS:Producto controlado<p>Impurity Mirtazapine<br>Applications A labelled metabolite of Mirtazapine, α2-adrenergic blocker.<br>References De Boer, T., et al.: Neuropharmacology, 27, 399 (1988), Smith, W.T., et al.: Psychopharmacol. Bull., 26, 191 (1990)<br></p>Fórmula:C16H11D6N3·2HClForma y color:NeatPeso molecular:330.29(3S-trans)-5-[[4-(4-Fluorophenyl)-3-piperidinyl]methoxy]-2-methoxyphenol (Paroxetine Metabolite)
CAS:Fórmula:C19H22FNO3Forma y color:White SolidPeso molecular:331.382-(1-Hydroxyethyl) Promazine-d4
CAS:Producto controlado<p>Applications A labelled metabolite of Acepromazine (A130900).<br>References Cossum, P., et al.: Drug Dispos., 9, 321 (1988), Stowell, L., et al.: J. Anal. Toxicol., 22, 166 (1998),<br></p>Fórmula:C19H20D4N2OSForma y color:NeatPeso molecular:332.5Deferiprone-d3 3-O-β-D-Glucuronide Sodium Salt
CAS:Producto controlado<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of Deferiprone (D474000).<br>References Choudhury, R., et al.: Drug Metab. Dispos., 23, 314 (1995);<br></p>Fórmula:C13H13D3NNaO8Forma y color:Off-White To Light BeigePeso molecular:340.28N-Desmethyl-N-cyclopentyl Tadalafil
CAS:Producto controlado<p>Applications N-Desmethyl-N-cyclopentyl Tadalafil is used as a reagent to synthesize tetracyclic cGMP-specific phosphodiesterase inhibitors, compounds that have potential to treat cardiovascular disorders and erectile dysfunction.<br>References Daugan, A. & Gellibert, F. Tetracyclic cGMP-specific Phosphodiesterase Inhibitors and Their Use in Disease Treatment. U.S. 6143746. Nov 7, 2000<br></p>Fórmula:C26H25N3O4Forma y color:NeatPeso molecular:443.492,3-Diphenylquinoxaline
CAS:Pureza:98.0%Forma y color:Solid, White - Pale reddish yellow powderPeso molecular:282.346008300781253-(1-Piperazinyl)-1,2-benzisothiazole
CAS:Producto controlado<p>Impurity Ziprasidone EP Impurity A<br>Applications 3-(1-Piperazinyl)-1,2-benzisothiazole (Ziprasidone EP Impurity A) is a reagent used to synthesize Ziprasidone (Z485000, HCl salt, monohydrate), a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prakash, C., et al.: Brit. J. Clin. Pharmacol., 49, 35S (2000); Orjales, A., et al.: J. Med. Chem., 46, 5512 (2003); Graham, J., et al.: Bioorg. Med. Chem. Lett., 18, 489 (2008); Bench, C.J., et al.: Psychopharmacology, 112, 308 (1993), Goldstein, J.M.: Exp. Opin. Invest. Drugs, 4, 291 (1995)<br></p>Fórmula:C11H13N3SForma y color:NeatPeso molecular:219.313-Methoxy-4-nitro-1H-pyrazole-5-carboxylic acid
CAS:Fórmula:C5H5N3O5Pureza:95.0%Forma y color:SolidPeso molecular:187.1114-methyl-N-(pyridin-3-ylmethyl)-1,3-benzothiazol-2-amine
CAS:Pureza:95.0%Peso molecular:255.339996337890625- tert -Butyl-2-methyl-4-nitro-2 H -pyrazole-3-carboxylic acid
CAS:Fórmula:C9H13N3O4Pureza:97%Forma y color:SolidPeso molecular:227.22rac-Epinephrine-3-O-sulfate
CAS:Fórmula:C9H13NO6SForma y color:White To Off-WhitePeso molecular:263.2682-Phenylphenol
CAS:<p>Applications 2-Phenylphenol is an agricultural fungicide and is no longer used as a food additive (1). It has been associated with the incidence of bladder cancer in male rats which may be related to its primary metabolite, phenylhydroquinone (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Gouin T. et al.: Environ Pollut. 2012 Jun;165:208-14. 2. Balakrishnan, S. et al.: Environ Mol Mutagen. 2016 Apr;57(3):210-9<br></p>Fórmula:C12H10OForma y color:Light PinkPeso molecular:170.212-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol
CAS:Producto controlado<p>Applications 2-(4-Methyl-2-phenyl-1-piperazinyl)-3-pyridinemethanol is an impurity found in Mirtazapine (M365000). Mirtazapine Impurity B.<br></p>Fórmula:C17H21N3OForma y color:White To Off-WhitePeso molecular:283.374-Cyano-3-trifluoromethylphenylisothiocyanate
CAS:Producto controladoFórmula:C9H3F3N2SForma y color:NeatPeso molecular:228.19rac N-Acetyl-Pseudoephedrine
CAS:Producto controlado<p>Applications rac N-Acetyl Pseudoephedrine is a racemic N-acetylated analogue of the non-selective adrenergic agonist Pseudoephedrine (P839350).<br>References Coutts, R.T. et al.: Biomed. Mass Spec., 11, 441 (1984);<br></p>Fórmula:C12H17NO2Forma y color:NeatPeso molecular:207.27rac-4-Hydroxy Propranolol-d7 Hydrochloride
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications A labelled metabolite of Propranolol.<br>References Walle, T., et al.: Drug Metab. Dispos., 13, 204 (1985), Mason, R., et al.: J. Med. Chem., 34, 869 (1991), Anderson, R., et al.: Biochem. Pharmacol., 52, 341 (1996), Hung, D., et al.: J. Pharmacol. Exp. Ther., 297, 780 (2001),<br></p>Fórmula:C16D7H14NO3·ClHForma y color:Light Red To BrownPeso molecular:318.85Nateglinide-d5
CAS:Producto controlado<p>Applications A labelled version of Nateglinide, an amino-acid derivative that stimulates insulin secretion which is used as an antidiabetic.<br>References Shinkai, H., et al.: J. Med. Chem., 32, 1436 (1989), Sato, Y., et al.: Diabetes Res. Clin. Pract., 12, 53 (1991), Vicent, D., et al.: J. Clin. Invest., 111, 1373 (2003), Ceriello, A., et al.: Diabet. Med., 21, 171 (2004),<br></p>Fórmula:C192H5H22NO3Forma y color:NeatPeso molecular:322.45Telmisartan
CAS:Producto controlado<p>Stability Hygroscopic<br>Applications Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Fórmula:C33H30N4O2Forma y color:NeatPeso molecular:514.62(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS:Producto controladoFórmula:C19H18IN3OForma y color:White To Light YellowPeso molecular:431.27Baricitinib
CAS:Producto controlado<p>Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.<br>References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);<br></p>Fórmula:C16H17N7O2SForma y color:White SolidPeso molecular:371.42Ketanserin
CAS:<p>Applications An antihypertensive, with affinity for multiple GPCR receptors.<br>References Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009), Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009), Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>Fórmula:C22H22FN3O3Forma y color:NeatPeso molecular:395.43Tropicamide
CAS:<p>Applications Ophthalmic anticholinergic. Mydriatic.<br>References Blessel, K.W., et al.: Anal. Profiles Drug Subs., 3, 565 (1974), Krapivinsky, G., et al.: J. Biol. Chem., 270, 29059 (1995), Bedingfield, J., et al.: Eur. J. Pharmacol., 309, 71 (1996), Jin, W., et al.: Biochemistry, 38, 14294 (1999), Kew, J., et al.: Pharmacol. Ther., 104, 233 ( 2004), Bertaso, F., et al.: J. Neurochem., 99, 288 (2006),<br></p>Fórmula:C17H20N2O2Forma y color:NeatPeso molecular:284.35N1-Ethylcarbamoyl Cabergoline (>90%)
CAS:Fórmula:C29H42N6O3Forma y color:Off White SolidPeso molecular:522.685-Amino-1-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-3-methyl-1H-pyrazole-4-carbonitrile
Pureza:95.0%Peso molecular:256.26501464843754-(2-Oxo-1,2,3,4-tetrahydroquinolin-6-yl)oxy Cilostazol (>85%)
CAS:Producto controlado<p>Stability Light Sensitive<br>Applications An impurity of Cilostazol (C441500) which is a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998), Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999), Tsuchikane, E., et al.: Circulation, 100, 21 (1999),<br></p>Fórmula:C29H34N6O4Pureza:>85%Forma y color:NeatPeso molecular:530.62
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