Aminoácidos (AA)

<p>Applications N-Benzyloxycarbonylglycine thioamide (cas# 49548-40-5) is a useful research chemical.<br></p>

<p>Applications 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is an intermediate used to prepare aminopyridopyrimidinones as tyrosine kinase inhibitors and anticancer agents. It is also used in the synthesis of piperazinyltrifluoromethylphenylquinolinylbenzonaphthyridinone derivatives with anticancer activities.<br>References Klutchko, S., et al.: J. Med. Chem., 41, 3276 (1998); Liu, Q., et al.: J. Med. Chem., 53, 7146 (2010)<br></p>

<p>Applications 5-Ethyl-4-hydroxy-2-methyl-3(2H)-furanone, mixture of isomers 96%, FG (cas# 27538-09-6) is a useful research chemical.<br></p>

<p>Applications 5-Methyl-1,3-cyclohexanedione has been used in the synthesis of racemic (±)-fawcettimine and 3,6-dimethyl-2-phenylsulfanyl-3,5,6,7-tetrahydro-2H-benzofuran-4-one.<br>References Xin, L., et al.: Angewandte Chemie (International Edition), 46, 7671 (2007); Lee, Y., et al.: Korean Chem. Soc., 23, 1477 (2002)<br></p>

<p>Applications 1-(4-Bromo-3-methylphenyl)ethanone<br></p>

<p>Applications N-Boc-3-(1-cyano-2-ethoxy-2-oxoethylidene)-1-piperidine is a useful synthetic intermediate.<br></p>

<p>Applications 2-(6-Methoxy-2-naphthyl)acetonitrile (cas# 71056-96-7) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Tigloylglycine-2,2-d2 (CAS# 1219806-44-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 3-(4-Methoxyphenoxy)benzoate is an intermediate in the synthesis of 3-(4'-Hydroxy)phenoxybenzoic Acid (H951225), which is a metabolite of pyrethroid insecticides such as: Deltamethrin, Permethrin, Cypermethrin, Fenvalerate, Decamethrin.<br>References Woollen, B., et al.: Xenobiotica, 22, 983 (1992), Saito, K., et al.: Toxicol. Sci., 57, 54 (2000), Fang, H., et al.: Chem. Res. Toxicol., 14, 280 (2001), Andersen, H., et al.: Toxicol. Appl. Pharmacol., 179, 1 (2002),<br></p>

<p>Applications N-Acetylglycine-13C2,15N is a labelled derivative of N-Acetylglycine (A178260(P)), which is a derivative of Glycine (G615990). Glycine is a useful intermediate for synthesizing rac 3-O-Methyl DOPA (M303805), which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003)<br></p>

<p>Applications 2-(5-Methoxybenzo[d]isoxazol-3-yl)acetic Acid (cas# 34172-98-0) could have agricultural applications specifically as a regulator for plant growth.<br>References Amorosi, S., et al.: Plant Growth Regul. Soc. Am., 22, 338 (1995)<br></p>

<p>Applications 3-Methoxy-3-methylbutyl Acetate (cas# 103429-90-9) is a useful research chemical.<br></p>

<p>Applications 4'-Chloro-N-methylformanilide (cas# 26772-93-0) is a useful research chemical.<br></p>

<p>Applications 5-Methyl-2-hexanone is used in the preparation od S1P1 receptor agonists. Also used in the preparation of indoles in an efficient synthesis involving the use of TCT (2,4,6-trichloro-1,3,5-triazine).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bolli, M. et al.: J. Med. Chem., 57, 78 (2014); Siddalingamurthy, E. et al.: Tetrahedron Lett., 54, 5591 (2013);<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications (2-METHYLAMINO-5-NITRO-PHENYL)-PHENYL-METHANONE (cas# 4958-56-9) is a useful research chemical.<br></p>

<p>Applications 6-Bromo-5-methyl-3h-imidazo[4,5-b]pyridine<br></p>

<p>Applications L-2-Nitrophenylalanine is a derivative of L-phenylalanine (P319415), and is used in the photocleavage of polypeptide backbones. L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine.<br>References Peters, F. et al.: Chem. Biol., 16, 148 (2009); Hollunger, G. et al.: Acta Pharmacol. Toxicol., 34, 391 (1974); Bagchi, S.P. et al.: Biochem. Pharmacol., 26, 900 (1977);<br></p>

<p>Applications 1-(7-amino-2-methyl-1-benzofuran-3-yl)ethanone (cas# 174186-83-5) is a useful research chemical.<br></p>

<p>Applications α-Methylglyceric Acid-d4 is derived from Acetone-d6 (A163802), which is an isotope labeled Acetone, a common organic building block in organic chemistry. Also, it is the deuterated form of α-Methylglyceric Acid (M311505), which is a biogenic secondary organic aerosol used in air quality diagnosis.<br>References Neubert, L., et al.: J. Am. Chem. Soc., 134, 12239 (2012); Zhai, J.J., et al.: J. Am. Soc. Mass. Spec., 20, 1366 (2009); Ru, P., et. al.: Environ. Sci. Technol., 48, 8491 (2014); Napelenok, S.L., et. al.: Environ. Sci. Technol., 48, 464 (2014); Stone, E.A., et. al.: Environ. Chem., 9, 263 (2012)<br></p>

<p>Applications 2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid (cas# 1289942-66-0) is a useful research chemical.<br></p>

<p>Applications A photolabile linker for the solid-phase synthesis of 4-substituted 1,2,3-triazoles.<br>References Qvortrup, K. et al.; Chem. Commun. 47, 3278 (2011)<br></p>

<p>Applications 4-Chloro-7-methoxy-2-methylquinoline (cas# 75896-68-3) is a useful reagent for preparing multi-substituted 4-anilinoquin(az)olines that have antiviral activity.<br>References Saul, S., et al.: Bioorg. Med. Chem. Lett., 30, 127284 (2020)<br></p>

<p>Applications 2-Bromo-3-methylphenol is a reagent used in chemoselective and regioselective oxybromination of phenols with dioxygen<br>References Menini, L., et al.: Tetrahedron Lett., 48, 6401 (2007)<br></p>

<p>Applications Fmoc-D-ser(Ac)-OH (cas# 608512-87-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-O-Octadecyl-2-O-methyl-rac-glycerol-d5 is labelled 1-O-Octadecyl-2-O-methyl-rac-glycerol (O236100) which is used to prepare homologous piperidine-containing alkyl glycerolipids with possible antitumor activities.<br>References Stekar, J., et al.: Angewandte Chemie, International Edition in English, 34, 238 (1995)<br></p>

<p>Applications 2-(4-Bromophenyl)-1-methyl-5-nitro-1H-benzo[d]imidazole has been used in the study of 5-nitrofuran derivatives as an inhibitor of nucleic acid and protein synthesis in Ehrlich ascites tumor cells.<br>References Fuska, J., et. al.: Neoplasma, 20, 171 (1973)<br></p>

<p>Applications n-Hexyl 4-Methyl-2-pentyl Phthalate, is the labeled analogue of n-Hexyl 4-Methyl-2-pentyl Phthalate (H297165), a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties.<br>References Wang, Zh., et al.: Guocheng Gongcheng Xuebao, 5 (6), 670 (2005);<br></p>

<p>Applications Methyl 5-Chloro-2-methoxy-4-trifluoroacetamidobenzoate (cas# 447438-06-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-[1-(1-benzofuran-2-yl)ethyl]-2-chloro-N-methylacetamide (cas# 1184567-77-8) is a useful research chemical.<br></p>

<p>Applications 2-Ethyl-6-methylaniline-d11 Labelled is an isotope labelled form of 2-Ethyl-6-methylaniline (E922060), which is used for the oral toxicity and lipophilicity studies of alkylanilines on rats.<br>References Jacobson, K. H., et al.: Toxicol. Appl. Pharmacol., 22, 153 (1972); Durden, J. A., et al.: J. Med. Chem., 16, 1316 (1973)<br></p>

<p>Applications 1-(4-METHYLPHENYL)-1-CYCLOPROPANECARBOXYLIC ACID (cas# 83846-66-6) is a useful research chemical.<br></p>

<p>Applications 3-(p-Methoxybenzoyl)indole is an intermediate in the synthesis of JWH derivatives.<br>References Guchhait, S.K., et al.: J. Org. Chem., 76, 4753 (2011)<br></p>

<p>Applications 8-Hydroxy-5-[2-[(1-methylethyl)amino]-1-oxobutyl]-2(1H)-quinolinone is an intermediate in the synthesis of metabolites of procaterol hydrochloride (Meptin) (P155490), a β2-adrenergic agonist used in the treatment of asthma.<br>References Yoshizaki, S., et al.: Chem. Pharma. Bull., 26, 1611 (1978);<br></p>

<p>Applications 4-ethyl-3-methyl-3-phenylpyrrolidine-2,5-dione (cas# 60-45-7) is a useful research chemical.<br></p>

<p>Applications 7-Methoxy-1-tetralone (cas# 6836-19-7) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-6-methyl-2-(methylthio)pyrimidine has been used in the synthesis of 4-chloro-2-(3,5-dimethyl-1h-pyrazol-1-yl)-6-methylpyrimidine.<br>References Kotaiah, S., et. al.: Heterocyclic Lett., 4, 335 (2014)<br></p>

<p>Applications 3-Chloro-6-methylpyridazine is used for preparation of heterocyclic compounds as integrase inhibiting antiviral agents.<br>References Betail, G., et al.: Ann. Pharm. Fr., 36, 317 (1978), Elben, U., et al.: J. Chem. Res., 316 (1978),<br></p>

<p>Applications 3-Methoxy-2-nitrobenzoic acid<br></p>

<p>Applications 4-METHYL-3-PENTEN-2-OL (cas# 4325-82-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 6-methoxy-2,3,4,9-tetrahydro-1H-beta-carbolin-1-one (cas# 17952-87-3) is a useful research chemical.<br></p>

<p>Applications 1-Methylthio-2-propanone is a thioether compound for proteomics research.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications An intermediate in the preparation of pharmaceutically active Cyproheptadines.<br>References Thompson, W., et al.: J. Med. Chem., 33, 789 (1990),<br></p>

<p>Applications methyl 2-methyl-4-oxobutanoate (cas# 13865-21-9) is a useful research chemical.<br></p>

<p>Applications 1-Benzyl-2-methyl-3-pyrrolidone (cas# 69079-26-1) is a compound useful in organic synthesis.<br>References Iwanami, S., et al.: J. Med. Chem., 24, 1224 (1981),<br></p>

<p>Applications 2-Amino-5-methyl-pyrimidin-4-ol is a useful reagent for the preparation of pyrimidines.<br>References Von, A. S., et al.: Science of Synthesis, 16, 379 (2004)<br></p>

<p>Applications (1S,2S)-Fmoc-acpc is used in preparation of chimeric (α/β + α)-peptide ligands for BH3-recognition cleft of the cancer-associated protein Bcl-xL.<br>References Sadowsky, J., et al.: J. Am. Chem. Soc., 127, 11966 (2005);<br></p>

<p>Applications 4-(1,1-Dimethylethyl)-2-(1-methylpropyl)-6-[2-(2-nitrophenyl)diazenyl]phenol is an intermediate in the synthesis of 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)phenol (B206645), which is often used to increase product stability and to prevent discolouration in various consumer and industrial goods such as plastics. Benzotriazole UV stabilizers, such as 2-(2H-Benzotriazol-2-yl)-4-(tert-butyl)-6-(sec-butyl)pheno, are pollutants for the aquatic environment and have been implicated as a potential stable and toxic ligands for the aryl hydrocarbon receptor in human.<br>References Liu, R., et al.: Talanta 120, 158 (2014); Nagayoshi, H., et al.: Environ Sci Technol. 49, 578 (2015).<br></p>

<p>Applications 3-Chloro-4-methylbenzoic acid<br></p>

<p>Applications 5,6-Difluoro-2-Hydrazino-1-Methyl-1H-benzimidazole is an intermediate used in the preparation of pentacyclic fluoroquinolines.<br>References Nosova, E. V., et al.: Russian J. Org. Chem., 34, 408 (1998)<br></p>

<p>Applications 6-(4-Aminophenoxy)-N-methyl-4-pyrimidinamine is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications (±)-Methyl 1,2,3,4-Tetrahydro-β-carboline-3-carboxylate, is an intermediate used for the synthesis of various pharmacutical and biologically active compounds. It is used for the synthesis of the marine indole alkaloid Eudistomin U. It is also an intermediate for the synthesis of Biriperone (B399750).<br>References Panarese, J. D., et al.: Org. Lett., 12 (18), 4086 (2010); Chakrabarty, R., et al.: Bioorg. Med. Chem., 15 (23), 7361 (2007);<br></p>

<p>Applications 1H-1,2,3-Triazole-5-methanamine Dihydrochloride is used in the preparation of optimized 5-membered heterocycle-linked pterins for inhibition of ricin toxin A. Also used in the synthesis of orally bioavailiable human neurokinin-1 (hNK1) antagonists.<br>References Lin, P. et al.: Bioorg. Med. Chem. Lett., 17, 5191 (2007); Pruet, J. et al.: ACS Med. Chem. Lett., 3, 588 (2012);<br></p>

<p>Applications 1,2-Dinitro-4,5-methylenedioxybenzene (cas# 7748-59-6) is a compound useful in organic synthesis.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Applications A boc-protected cyclic amine used in the preparation of heterocyclic boronic acid compounds.<br></p>

<p>Applications tert-Butoxycarbonyl-D-valine is used in the preparation of selective CCR1 antagonists in the treatment of rheumatoid arthritis. Also used in the preparation of antileishmanial agents.<br>References Gardner, D. et al.: Bioorg. Med. Chem. Lett., 23, 3833 (2013); Casanova, E. et al.: ChemMedChem., 8, 1161 (2013);<br></p>

<p>Applications o-Coumaric Acid 4-O-β-D-Glucuronide is a metabolite of either Coumarin (C755380) or o-Hydroxy-cinnamic Acid (614-60-8).<br></p>

<p>Applications Tetrahydro-5-methyl-2-furanmethanol, is shown to be one of the volatile components in grapes, milk, and etc.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mentasti, T., et al.: Milchwissenchaft, 52, 253 (1997);<br></p>

<p>Applications 2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-Fluoro-4-methylbenzyl Bromide is used as a reagent in the synthesis of tetrahydrocarboline derivatives which can serve as inhibitors of ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2). 2-Fluoro-4-methylbenzyl Bromide is also used as a reagent in the preparation of benzamide derivatives as angiogenesis inhibitors for treatment of cancer, metastasis.<br>References Ohata, A., et al.: PCT Int. Appl. WO 2012005227 A1 20120112. Jan 12, 2012; Koyano, H., et al.: PCT Int. Appl. WO 2005063689 A1 20050714. Jul 14, 2005<br></p>