Péptidos

Sarafotoxin S6b, sourced from the venom of the Atractaspis engaddensis snake family, is one of four (S6a-d) isopeptides of the Sarafotoxins. This product is a synthetically produced toxin, containing disulfide bonds between Cys1-Cys15 and Cys3-Cys11.Due to their structural and functional homology to the endothelin peptides, Sarafotoxins can enhance vasoconstriction through stimulating the class A G-protein-coupled, endothelin ETA and ETB receptors. This in turn leads to left ventricular dysfunction and bronchoconstriction.
As the most potent Sarafotoxin, sarafotoxin S6b binds to both ETA and ETB receptors with a similar affinity to Endothelin-1. This is evident as when given to mice intravenously, sarafotoxin S6b caused cardiac arrest and death in mice almost immediately. Additional characteristics of S6b is its matrix metalloproteinase inhibitory activity due to it exhibiting a fold which is also found in the core region of tissue inhibitors of metalloproteinases (TIMPs).
Sarafotoxin S6b can be used as a pharmacological reagent to study the interactions of Endothelins and their corresponding receptors. This product is available as a 0.1mg vial.

A synthetic peptide for use as a blocking control in assays to test for specificity of C10orf83 antibody, catalog no. 70R-3297

A synthetic peptide for use as a blocking control in assays to test for specificity of NSMCE1 antibody, catalog no. 70R-2769

A synthetic peptide for use as a blocking control in assays to test for specificity of HSPE1 antibody, catalog no. 70R-4219

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF486 antibody, catalog no. 70R-9107

A synthetic peptide for use as a blocking control in assays to test for specificity of SMPD1 antibody, catalog no. 70R-7120

A synthetic peptide for use as a blocking control in assays to test for specificity of HABP2 antibody, catalog no. 70R-6071

A synthetic peptide for use as a blocking control in assays to test for specificity of Pcyt2 antibody, catalog no. 70R-9234

The LRG1 Blocking Peptide is a highly effective monoclonal antibody that acts as a phosphatase inhibitor in Life Sciences research. This neutralizing peptide is widely used in the field of monoclonal antibodies and has been proven to effectively block the activity of LRG1, a glycoprotein involved in various biological processes.

A synthetic peptide for use as a blocking control in assays to test for specificity of ASL antibody, catalog no. 70R-1176

A synthetic peptide for use as a blocking control in assays to test for specificity of FCRL1 antibody, catalog no. 70R-1853

A synthetic peptide for use as a blocking control in assays to test for specificity of C21orf13 antibody, catalog no. 70R-1973

A synthetic peptide for use as a blocking control in assays to test for specificity of PAFAH1B1 antibody, catalog no. 70R-5657

A synthetic peptide for use as a blocking control in assays to test for specificity of NRP1 antibody, catalog no. 70R-9671

A synthetic peptide for use as a blocking control in assays to test for specificity of SPTAN1 antibody, catalog no. 70R-2207

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM120C antibody, catalog no. 70R-10170

Cysteine peptide (Ac RFAAKAA COOH) is used in combination with Lysinepeptide (Ac RFAACAA COOH) in the Direct Peptide Reactivity Assay (DPRA) test.
Direct Peptide Reactivity Assay is used in cosmetic applications for the characterization of the skin sensitizing potential of a substance, framed by OECD Guideline no 442.
The molecular initiating event (MIE) in skin sensitization is a binding between epidermal proteins and the sensitizing chemical substance. MIE is part of the adverse outcome pathway (AOP) of skin sensitization.
It is thanks to the properties of Lysine peptide and Cysteine peptide that the chemical binding will be able to take place, so these synthetic heptapeptides will mimic the reaction of a skin exposed to a substance.
Binding between nucleophilic proteins and electrophile substance will be measured by High Performance Liquid Chromatography (HPLC). Therefore, the decrease in Lysine peptide and Cysteine peptide levels will be a sign of sensitizing event. Depending on the rate of depletion, the sensitizing character of a molecule will be determined (see table at the bottom of the page).
In chemico DPRA test also has wider applications such as hazard classification in cosmetics, but also for pharmaceuticals and biocides. It is a good alternative to animal experimentation.

A synthetic peptide for use as a blocking control in assays to test for specificity of TTC5 antibody, catalog no. 70R-2121

MOG(35-55) human corresponds to amino acids 35 to 55 of the human myelin oligodendrocyte glycoprotein (MOG). It can be used in multiple sclerosis research to induce experimental autoimmune encephalomyelitis (EAE) in mouse and rat models.

A synthetic peptide for use as a blocking control in assays to test for specificity of RBMS3 antibody, catalog no. 70R-4798

Insulin is a hormone that regulates the metabolism of carbohydrates and fats. It is produced by beta cells in the pancreas and prevents hyperglycemia. Insulin binds to insulin-specific receptors on the cell membrane, resulting in increased glucose uptake by muscle and fat cells. Monoclonal Mouse Anti-Human Insulin is an antibody that binds to human insulin and blocks its action, thereby lowering blood sugar levels. This antibody was immunised with human insulin and purified from mouse spleen cells. The antibody has been shown to block glycogen synthesis and fatty acid synthesis in vitro. Monoclonal Mouse Anti-Human Insulin also has a high binding affinity for erythrocytes and penetrates these cells easily. When injected into humans, this antibody binds to the erythrocytes in the blood stream and prevents their passage through capillary walls into tissues such as muscle or fat cells, thereby preventing glycolysis (the conversion of glucose into energy) in those tissues

Bovine Serum Albumin (BSA) is a protein that is used in the pharmaceutical industry as a research tool and an immunological reagent. BSA can be used to bind, stabilize, and prevent denaturation of other proteins in the laboratory. It has been shown to inhibit ion channels and ligand-gated ion channels, which are important for membrane potentials. BSA is also an activator of receptor tyrosine kinases, which are involved in cell signaling pathways.

A synthetic peptide for use as a blocking control in assays to test for specificity of DIDO1 antibody, catalog no. 70R-8367

Custom research peptide; min purity 95%.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF286 antibody, catalog no. 70R-8091

A synthetic peptide for use as a blocking control in assays to test for specificity of CSNK2A2 antibody, catalog no. 70R-3332

Azido-dPEG®3-Amine is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®3-Amine is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

A synthetic peptide for use as a blocking control in assays to test for specificity of RPAIN antibody, catalog no. 70R-8518

A synthetic peptide for use as a blocking control in assays to test for specificity of ARL17 antibody, catalog no. 70R-3805

A synthetic peptide for use as a blocking control in assays to test for specificity of Gcom1 antibody, catalog no. 70R-3275

A synthetic peptide for use as a blocking control in assays to test for specificity of BCO2 antibody, catalog no. 70R-10117

A synthetic peptide for use as a blocking control in assays to test for specificity of FOXN4 antibody, catalog no. 70R-8770

A synthetic peptide for use as a blocking control in assays to test for specificity of GTPBP10 antibody, catalog no. 70R-2020

A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2L3 antibody, catalog no. 70R-3085

Custom research peptide; min purity 95%.

CD2, human, recombinant is a research peptide that is commonly used in scientific studies. It is a protein that is produced using Escherichia Coli bacteria. CD2 plays an important role in immune responses and cell signaling. This recombinant form of CD2 allows researchers to study its function and interactions with other molecules in a controlled laboratory setting. It can be used in various experiments and assays to investigate the mechanisms of immune system regulation and develop potential therapeutic interventions. With its high purity and quality, CD2, human, recombinant is a valuable tool for researchers in the field of immunology and molecular biology.

A synthetic peptide for use as a blocking control in assays to test for specificity of CYP2R1 antibody, catalog no. 70R-8833

This product has disulfide bonds between Cys1-Cys15 and Cys3-Cys11 and is available as a 0.1mg vial. Big Endothelin-1 (Human, 1-38) is part of the full lengthed 29 amino acid peptide Big Endothlin-1 which is a precursor peptide of the vasoconstrictorEndothelin-1 (ET-1). ET-1 exhibits vasoconstrictive properties and is an activator of endothelin G-protein coupled receptors. Furthermore ET-1 is produced when inflammation, vascular stress or hypoxia occurs. In vivo Big Endothelin-1 has a greater half life compared to ET-1 and therefore makes it useful to study secretory activity in the endothelial system.
Overall Big Endothelin-1 (Human, 1-38) can be used as a research tool for studying protein interactions, receptor activation and function, and ligand binding. This peptide is also used in pharmacology to study the effects of therapeutic agents on receptor activity and expression.

A synthetic peptide for use as a blocking control in assays to test for specificity of DUS1L antibody, catalog no. 70R-4013

A synthetic peptide for use as a blocking control in assays to test for specificity of UBE2J1 antibody, catalog no. 70R-1776

A synthetic peptide for use as a blocking control in assays to test for specificity of RNF121 antibody, catalog no. 70R-6550

A synthetic peptide for use as a blocking control in assays to test for specificity of PQLC1 antibody, catalog no. 70R-7332

A synthetic peptide for use as a blocking control in assays to test for specificity of AIFM3 antibody, catalog no. 70R-2470

HG1 toxin is a peptide that is found in the venom of the scorpion Heterometrus fulvipes. It is a member of the short-chain scorpion toxins, which are composed of a single chain of amino acids. This protein has been shown to bind to potassium channels and inhibit their function, leading to paralysis of the prey's nervous system. HG1 toxin has been shown to be able to activate or inhibit ion channels and other receptors. It can also bind to ligands such as peptides or antibodies and affect cellular activity. HG1 toxin is produced by recombinant DNA technology and purified by HPLC for use in biochemical research and pharmacological studies.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZCCHC17 antibody, catalog no. 70R-4635

A synthetic peptide for use as a blocking control in assays to test for specificity of C14orf130 antibody, catalog no. 70R-1165

Antipain is a proteolytic enzyme that hydrolyzes peptide bonds in proteins. It is a member of the papain family of proteases and has been shown to activate peptides and inhibit ion channels, both of which are important for cell biology research. Antipain, an inhibitor of protein synthesis, is also used as a research tool in cell biology and biochemistry.

A synthetic peptide for use as a blocking control in assays to test for specificity of LANCL2 antibody, catalog no. 70R-2713

Custom research peptide; min purity 95%.

A synthetic peptide for use as a blocking control in assays to test for specificity of ADAMTS18 antibody, catalog no. 70R-4602

A synthetic peptide for use as a blocking control in assays to test for specificity of PIGT antibody, catalog no. 70R-7466

A synthetic peptide for use as a blocking control in assays to test for specificity of Sin3b antibody, catalog no. 70R-8194

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Please enquire for more information about Fluorescein-6-carbonyl-Leu-Glu(OMe)-His-DL-Asp(OMe)-fluoromethylketone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

CJC-1295 is a synthetic peptide, which is an analogue of growth hormone-releasing hormone (GHRH). It is synthesized through recombinant DNA technology, which allows for precise control over its sequence and length. This particular peptide is designed to bind to GHRH receptors in the pituitary gland. By activating these receptors, CJC-1295 stimulates the release of growth hormone (GH) into the bloodstream.The primary function of CJC-1295 is to influence the endocrine system, particularly enhancing the release of endogenous growth hormone. It achieves this by increasing the amplitude and frequency of GH pulses without affecting the natural negative feedback mechanisms that regulate GH production. This mode of action distinguishes CJC-1295 from other growth hormone therapies, as it promotes a more physiological pattern of hormone secretion.CJC-1295 is used in various scientific contexts, primarily in research focusing on growth hormone deficiencies, muscle wasting conditions, and certain metabolic disorders. Its ability to increase GH release also makes it a subject of interest in studies related to aging, tissue repair, and regeneration. The longer half-life of CJC-1295 compared to natural GHRH peptides further enhances its applications in research, allowing for more sustained and controlled experimentation.

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Extraordinary strength of the streptavidin-biotin interaction allows for efficient capturing of even highly dilute targets; however, it makes recovery of proteins from affinity resins challenging. Conventional methods to elute biotinylated proteins from immobilized avidin include the following: (i) denaturation of streptavidin by boiling the resin in a denaturing buffer that may include high concentrations of chaotropic salts, (ii) trypsin digestion of proteins while they are bound to the resin, or (iii) elution of proteins with excess free biotin. These protocols can co-elute contaminant proteins by releasing nonspecifically bound proteins and/or naturally biotinylated proteins concurrently with labeled proteins. In addition, some of these methods can cause elution of high levels of resin-based peptides along with the proteins of interest, resulting in further sample contamination.
Disulfide Biotin Azide probe eliminates a major limitation of the streptavidin-biotin affinity purification. This reagent contains a biotin moiety linked to an azide moiety through a spacer arm containing a cleavable disulfide linker. Captured biomolecules can be efficiently released under mild conditions (50 mM dithiothreitol, 10 mM 2-mercaptoethanol or 1% sodium borohydride) and the small molecular fragment (188.25 Da) left on the labeled protein following cleavage. These features make the cleavable probe especially attractive for use in biomolecular labeling and proteomic studies.

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity

Myelin oligodendrocyte glycoprotein (MOG) is a myelin protein found in the central nervous system. MOG is a ligand for CD200, which is an inhibitory receptor expressed by astrocytes. It has been shown that MOG can induce the proliferation and differentiation of primary cultures of rat astrocytes in vitro. MOG induces the production of reactive oxygen species in mitochondria and increases the expression of acid-binding protein, which are both important factors in the demyelination process. MOG has also been implicated as a potential factor in the development of multiple sclerosis. Further research into this protein may lead to new treatments or cures for disorders such as encephalomyelitis, nervous system diseases, or even cancer.

Catalogue peptide; min. 95% purity

H-His-Arg-OH is a synthetic peptide that has been shown to have cytotoxic effects on mammalian cells. The H-His-Arg-OH peptide can be used for the treatment of heart disease and autoimmune diseases, such as rheumatoid arthritis. This peptide has been found to be resistant to congestive heart failure, which is caused by a number of factors, including hypertension and valvular stenosis. It has also been shown to have an immunoglobulin G1 (IgG1) genotype.

Catalogue peptide; min. 95% purity

Catalogue peptide; min. 95% purity