Péptidos

IL-15 is a cytokine that belongs to the IL-2 family and is produced by activated T cells. IL-15 binds with high affinity to the IL-15 receptor, which then signals through the JAK/STAT pathway. IL-15 has been shown to activate NK cells and stimulate their production of IFNγ. In addition, IL-15 has been shown to cause activation of certain B cells, which leads to increased antibody production. This cytokine also stimulates proliferation of CD4+ and CD8+ T cells and induces differentiation into Th1 or cytotoxic T cell subsets.

Cortistatin is a peptide that belongs to the group of activators. It is a high-purity product with an amino acid sequence identical to cortistatin (rat). Cortistatin activates ion channels, which may be due to its ability to bind to receptors and ligands. This product can be used in life science research or cell biology experiments as an inhibitor or as a tool for protein interactions. The CAS number for this product is 937031-00-0.

Anti G-Protein: Galpha olf (23-38), humanSerum is a research tool that is used to study protein interactions. It can be used for the investigation of ion channels, cell biology, and pharmacology. The antibody reacts with the specific antigen for which it was raised. The antibody may be used in immunohistochemistry on tissue sections or in ELISA as a detection tool.

Azido-dPEG®4-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu is a research tool that belongs to the group of activators. It activates receptors and ion channels. This product has been shown to inhibit cell proliferation, peptide binding and protein interactions. 1-Deoxyfructosyl-Val-His-[D7]Leu-Thr-Pro-Glu is a high purity and potent inhibitor of protein interactions with pharmacological applications.

Amino-dPEG®4-t-Butyl Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®4-t-Butyl Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Bis-dPEG®13-Acid is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®13-Acid is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Epoxomicin is an activator that binds to the ligand-binding site of a receptor. It has been used as a research tool in cell biology, pharmacology, and immunology. Epoxomicin has been shown to inhibit ion channels by binding to them and blocking their activity. This property makes epoxomicin a good candidate for the treatment of epilepsy. Epoxomicin also inhibits protein synthesis through inhibition of ribosomal S6 kinase, which is involved in signal transduction pathways.

m-dPEG®48-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®48-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

MOG(91-108) corresponds to amino acids 97 to 108 of the rat myelin oligodendrocyte glycoprotein (MOG).

t-boc-N-Amido-dPEG®12-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, t-boc-N-amido-dPEG®12-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

MAL-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

BNP-32 is a peptide that is an activator of the B2 receptor. It has been shown to inhibit the ion channels in cells, which may be due to its binding to the ligand-binding site on the receptor. BNP-32 has also been shown to bind to antibodies and can be used as a research tool for cell biology or other areas of life science. BNP-32 is a high purity product with CAS No. 123337-89-3.

The cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that regulates the transcription of several genes that mediate important cellular processes. CREB is phosphorylated by several kinases, including PKA- Akt- and CamK I, II, and IV. Phosphorylated pCREB translocates to the nucleus, where it forms homodimers or heterodimers, and recruits p300/CREB binding protein (CBP) to initiate transcription of its target genes. pCREB is an important regulator of apoptosis and is also involved in modulating several immune processes and neuronal plasticity. CREB signalling has a critical role in the formation of memories and may be dysfunctional in the brains of Alzheimer's disease (AD).Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

Neurokinin A is a peptide that belongs to the tachykinin family and has been shown to activate receptors, such as NK-1. It is a potent inhibitor of ion channels and has also been shown to inhibit ligand binding to the receptor. Neurokinin A is used in research for studying protein interactions, receptor effects, peptides, and ion channels. It can be used in cell biology for studying life science and research tools for high purity and antibody production. This product is not intended for therapeutic use.

Bz-Ala-OMe is a reactive mercuric chloride that undergoes hydrolysis to form reactive mercuric acetate. It has been shown that the activation energy of the reaction is high and the reaction can be initiated by soybean trypsin. The reactive site of Bz-Ala-OMe is composed of chloride atoms and sephadex g-100. This compound reacts with serine proteases, such as trypsin or chymotrypsin, to form an amide intermediate. This intermediate reacts with n-acetyl-l-tyrosine to produce a chloromethyl ketone which then undergoes a nucleophilic attack by histidine to produce histamine in the presence of H2O2 or O2. Histamine binds to H1 receptors in the body, leading to an inflammatory response.

Amylin is a peptide that belongs to the group of activators. It has been shown to be an inhibitor of ion channels, and has also been demonstrated to activate cell signaling pathways. Amylin can be used as a research tool for studying protein interactions, receptor ligands, and pharmacology. Amylin can be used in antibody production or as a high-purity reagent for life science or cell biology applications.

Azido-dPEG®4-NHS ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Azido-dPEG®4-NHS ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.
Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.

ANP (Rat, 3-28) is a peptide that is a potent inhibitor of protein interactions. This peptide binds to the ligand-binding domain of the receptor and blocks the binding of the ligand. ANP (Rat, 3-28) also has high purity and can be used as a research tool or an antibody in life science studies.

Met-Met is a dipeptide that is synthesized from the amino acids methionine and methyltetrahydrofolate. It is used in the synthesis of peptides and biochemicals, as well as in pharmacological treatments for diseases including bacterial infections. Met-Met has significant interactions with dopamine, catechol-o-methyltransferase, and energy metabolism. The enzyme catechol-o-methyltransferase catalyzes the conversion of dopamine to 3,4-dihydroxyphenylacetic acid (DOPAC), which may lead to a decrease in dopamine levels. Met-Met also inhibits the metabolism of catecholamines, leading to an increase in cellular levels of catecholamines such as dopamine and norepinephrine. This inhibition may be responsible for metabolic disorders such as obesity or low body mass index (BMI)

Bz-Arg-AMC is a fluorescent probe that binds to the nicotinic acetylcholine receptor (nAChR) in the presence of calcium ions and emits light when excited by ultraviolet light. It can be used to study the activation of nAChRs, as well as their interactions with other proteins such as peptides. Bz-Arg-AMC has a molecular weight of 551.9 g/mol, with a purity of > 98% and an optical purity of > 99%. This product can be used for research purposes only, not for diagnostic or therapeutic purposes.

Dns-Glu(Cys-Gly) is a peptide that is reactive and can be used as a biochemical. It has been shown to have both reactive metabolites and biologically active peptides.

The leptin (RAT)-HS ELISA Kit is a sandwich enzyme-linked immunosorbent assay kit for the quantitative measurement of rat leptin in serum or plasma. Rat leptin is a protein hormone that regulates body weight, food intake, and energy expenditure. Leptin is synthesized and secreted by adipose tissue in proportion to fat mass. The human form of this hormone is called human leptin.

Amino-dPEG®12-ODMT is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Amino-dPEG®12-ODMT is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Anti Galanin (9-30), humanSerum is a peptide that inhibits the activity of galanin, which is a neuropeptide. It has been shown to have an effect on ion channels and receptors in the central nervous system. Anti Galanin (9-30), humanSerum binds to the receptor for galanin and blocks the binding of galanin molecules to these receptors, preventing activation of these cells. Anti Galanin (9-30), humanSerum is used as a research tool for studying protein interactions and as a pharmacological inhibitor for studying ion channels and receptors in the central nervous system.

Azido-dPEG®36-Alcohol is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, azido-dPEG®36-Alcohol is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

H-Gln-2-ClTrt-Resin is a resin that consists of polystyrene crosslinked with divinylbenzene. It is used in peptide synthesis to provide amino acids and building blocks for the synthesis of peptides and proteins. This resin can be used as a component in the production of amines, alcohols, thiols, and other organic compounds. The crosslinking agent in this resin is divinylbenzene (DVB).

MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg is a peptide with ion channel activity. It is a potent activator of potassium channels and has been used in research as a tool for studying ion channel function. MOCAc is not an inhibitor of voltage sensitive sodium channels but does inhibit calcium currents. MOCAc also has been shown to be a ligand for the nicotinic acetylcholine receptor and is able to bind to the beta subunit of this receptor. This peptide binds to the alpha subunit of the calcium channel, leading to inhibition of calcium currents and activation of potassium channels.

TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.

m-dPEG®24-MAL is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®24-MAL is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.