Péptidos

GAP is a natural peptide that has been found to bind to the G protein coupled receptor (GPCR) known as gonadotropin-releasing hormone receptor (GnRH-R). This receptor is linked to ion channels and plays a role in many different biological processes, including cell division and growth. GAP can be used as a research tool for studying how cells work. It can also be used in pharmacology studies, such as determining the effect of GAP on the activity of ion channels or protein interactions.

The cyclic AMP (cAMP) response element binding protein (CREB) is a transcription factor that regulates the transcription of several genes that mediate important cellular processes. CREB is phosphorylated by several kinases, including PKA- Akt- and CamK I, II, and IV. Phosphorylated pCREB translocates to the nucleus, where it forms homodimers or heterodimers, and recruits p300/CREB binding protein (CBP) to initiate transcription of its target genes. pCREB is an important regulator of apoptosis and is also involved in modulating several immune processes and neuronal plasticity. CREB signalling has a critical role in the formation of memories and may be dysfunctional in the brains of Alzheimer's disease (AD).Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.

TFF1 is a protein that belongs to the TNF family of cytokines. It is a homodimer with two identical chains that are linked by disulfide bonds at specific positions. TFF1 has been shown to be secreted by monocytes, macrophages, and lymphocytes in response to LPS stimulation. TFF1 binds to the cell membrane of target cells and induces proinflammatory responses such as cytokine production and the activation of NF-κB. These effects are mediated through its ability to activate the transcription factor nuclear factor-κB (NF-κB) which regulates gene expression in immune cells.
DISULFIDE BONDS: The covalent linkage between two polypeptide chains or between two amino acid residues
CHROMATOGRAPHY: A process for separating mixtures based on molecular weight, size, shape, or other physical properties
RECOMBINANT: Produced by recombining genetic material from different

t-boc-N-Amido-dPEG®12-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, t-boc-N-amido-dPEG®12-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

TentaGel® R PHB Resin (90 um) can be used for the preparation of peptide acids; particle size 90 µm; capacity: 018-023 meq/g and is specially designed for difficult and long sequences.
TentaGel, is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.

MAL-dPEG®8-Acid is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. MAL-dPEG®8-Acid is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

3x DYKDDDDK peptide, also called 3x FLAG peptide, is a 23 aa length peptide used for the competitive elution of DYKDDDDK-tag fusion proteins (with excess of free 3x DYKDDDDK peptide) under non-denaturing conditions, especially when a DYKDDDDK-tagged protein is sensitive to low pH.

A synthetic peptide for use as a blocking control in assays to test for specificity of FAM113A antibody, catalog no. 70R-4106

A synthetic peptide for use as a blocking control in assays to test for specificity of NAT12 antibody, catalog no. 70R-2955

Insulin is a peptide hormone that regulates the metabolism of carbohydrates, fats, and proteins. Insulin has been shown to bind to insulin receptors in the cell membrane. When insulin binds to the receptor, it triggers a series of biochemical reactions that lead to increased glucose uptake by cells and increased synthesis of glycogen in the liver. Insulin also activates ion channels, which leads to an increase in calcium influx into cells. Insulin is involved in many other functions within the body, such as promoting growth and development, regulating protein synthesis, and controlling lipid storage.
Insulin is used as a research tool for studying carbohydrate metabolism or as an antidiabetic drug for people who have diabetes mellitus. The most common form of insulin used today is human recombinant insulin (H-insulin). Human recombinant insulin can be synthesized from genetically engineered bacteria or yeast cultures.

DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. DOTA-tris(Acid)-Amido-dPEG®11-Maleimide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Bromoacetamido-dPEG®23-Azide is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. Bromoacetamido-dPEG®23-Azide is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Carboxyfluorescein-dPEG®24-Amido-dPEG®24-DSPE is a PEG compound containing a fluorescein dye used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.

Atosiban is a drug that is used to prevent preterm labor in pregnant women. It works by inhibiting the release of oxytocin from the hypothalamus, which decreases contractions and relaxes the uterus. Atosiban has been shown to be effective in decreasing the incidence of preterm birth in women with bacterial vaginosis who are at high risk for preterm delivery (e.g., those with a history of preterm labor). Clinical trials have shown that it may also be useful as an adjunct therapy in treating women with unexplained infertility and recurrent pregnancy loss. The drug binds to receptors on cells, which inhibits the release of intracellular calcium, thus preventing contraction of uterine muscle cells. This effect can be reversed by administration of estradiol benzoate or other drugs that affect receptor activity. It is not known whether atosiban affects fetal development during pregnancy or if it causes any effects on the mother's heart rate or body mass index after childbirth.

IL-1 beta is a cytokine, which belongs to the IL-1 family of cytokines. It is a proinflammatory cytokine that induces fever and pain, and stimulates the immune system. IL-1 beta binds to the IL-1 receptor, which is a member of the class 1 cytokine receptor family. The binding activates phospholipase A2 and protein kinase C, which leads to an increase in prostaglandin production by cyclooxygenase 2. IL-1 beta also has been shown to inhibit ion channel activity and calcium uptake in cells.

Antithrombin III heavy tryptic peptide standard for protein identification and quantitation studies. Antithrombin III is a glycoprotein found in blood plasma and is involved in the regulation of the coagulation process.

A synthetic peptide for use as a blocking control in assays to test for specificity of ZFP91 antibody, catalog no. 20R-1105

A synthetic peptide for use as a blocking control in assays to test for specificity of Cyyr1 antibody, catalog no. 70R-8636

A synthetic peptide for use as a blocking control in assays to test for specificity of Dag1 antibody, catalog no. 70R-8652

TentaGel® XV RAM is a particle-based reagent for peptide synthesis. It contains the building blocks for peptides and has been designed to be used in conjunction with a TentaGel® XV reactor. This product is designed to increase the yield of peptides via the use of a patented process that eliminates the need for purification and can reduce reaction time by up to 50%.

FRETS-25Lys is a peptide that can be used as an activator, inhibitor, or ligand for various receptors and ion channels. It has been shown to bind with high affinity to the acetylcholine receptor on the surface of muscle cells. FRETS-25Lys also inhibits the interaction between protein kinase C (PKC) and phospholipase Cγ2 (PLCγ2).

CRF is a human antibody that is used as a research tool. It has reactivity with cells that are activated by CRF, and binds to the receptor on these cells. CRF is also known as a ligand, which can bind to the receptor and trigger changes in the cell, such as ion channels or protein interactions. CRF is an activator of G-protein coupled receptors.

Ac-Asp-Gln-Thr-Asp-AMC is a synthetic peptide that is used as a research tool for the study of protein interactions and protein function. It can be used to inhibit the activity of ion channels, such as potassium channels, and to activate cell surface receptors. Ac-Asp-Gln-Thr-Asp-AMC has an amino acid sequence that resembles peptides found in naturally occurring proteins. Ac-Asp-Gln-Thr-Asp-AMC also has a molecular weight of 333.6 daltons and a CAS number of 125094–99–0.

Abaecin is a proline-rich cationic antimicrobial peptide (PrAMP) and was isolated from Apis mellifera. Abaecin is a 34 amino acid peptide including 10 prolines positioned uniformly which prevents the α-helical conformation.

Neurokinin A is a peptide that belongs to the tachykinin family and has been shown to activate receptors, such as NK-1. It is a potent inhibitor of ion channels and has also been shown to inhibit ligand binding to the receptor. Neurokinin A is used in research for studying protein interactions, receptor effects, peptides, and ion channels. It can be used in cell biology for studying life science and research tools for high purity and antibody production. This product is not intended for therapeutic use.

A synthetic peptide for use as a blocking control in assays to test for specificity of INSIG1 antibody, catalog no. 70R-6594