Péptidos
Subcategorías de "Péptidos"
Se han encontrado 29708 productos de "Péptidos"
Hp1404
Antimicrobial peptides (AMP) are proving a lucrative area for antibiotics in the era of bacterial resistance. Of note, the scorpion Heterometrus petersii was found to produce Hp1404, an amphipathic cationic peptide with specific activity against Gram-positive bacteria- Hp1404 was shown to be effective against methicillin-resistant Staphylococcus aureus (MRSA). The mode of action is by membrane penetration and disruption. MRSA did not gain resistance after several exposures to Hp1404 suggesting it may be a key agent against the rise of antibiotic resistance. Importantly, bacterial lethality was maintained with low toxicity to mammalian cells. Hp1404 is being used to generate analogues with reduced toxicity to mammalian cells and improved antimicrobial potency against a wider range of organisms.Forma y color:PowderPeso molecular:1,544.9 g/molDAG peptide
Cyclic DAG peptide targets connective tissue growth factor (CTGF/CCN2), present in the extracellular matrix, endothelial cells and overexpressed in several brain diseases. CTGF is a matricellular protein that acts as a regulator of several cellular functions, including cell adhesion, migration, mitogenesis, differentiation, and survival. CTGF is up regulated in Alzheimer's disease, Parkinson's disease, brain injury, glioblastoma, and cerebral infarction.DAG peptide has been shown to home to the brain in mouse models of glioblastoma, traumatic brain injury, and Parkinson's disease when exogenously delivered, making it an attractive target for the treatment of glioblastoma. DAG may be of use as a tool to enhance delivery of therapeutics and imaging agents to sites of brain diseases.Peso molecular:1,005.4 g/molH-KHNLGHGHKHERDQGHGHQR-NTBiot
Peptide H-KHNLGHGHKHERDQGHGHQR-NTBiot is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.[5-FAM]-CADY
Amphipathic helical peptide derived from the chimeric PPTG1 peptide and labelled at the N-terminus with fluorescein.Peso molecular:3,038.6 g/molPep - 1: Chariot
Pep-1 is a synthetic cell-penetrating peptide (CPP), and has been successfully used to deliver a variety of proteins and other biopharmaceutical macromolecules into cells in a non-disruptive manner. It is a CPP with primary amphipathicity, which results from its amino acid sequence as opposed to its folding structure. The primary structure of Pep-1: Chariot comprises three main domains: a tryptophan-rich, hydrophobic domain, and a hydrophilic domain derived from an NLS (nuclear localisation signal) of SV40 (simian virus 40) large T-antigen, and a spacer.
Forma y color:PowderPeso molecular:2,846.5 g/molH-VAAEDWK^-OH
Peptide H-VAAEDWK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-TGLQLSQDPTGR^-OH
Peptide H-TGLQLSQDPTGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SARS-CoV-2 NSP13 (226-240)
The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication. NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (226-240) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecular:1,565.9 g/mol[Pyr]-Apelin-13
CAS:[Pyr1]-Apelin-13 acts as a ligand for the apelin receptor (APJ) G protein-coupled receptor and is a substrate for angiotensin-converting enzyme 2. Apelin is a member of the adipokine hormone family from adipose tissue. Adipokines are involved in processes such as vascular homeostasis and angiogenesis.Apelin and the apelin receptor are widely distributed throughout the body. Apelin is associated with cardiovascular diseases, obesity, diabetes and cancer. Apelin is expressed in the spinal cord and the human brain. Immunohistochemistry shows that apelin-17 is significantly expressed in the human heart, brain, lungs and endothelial cells. Studies show myocardial infarction apelin mRNA expression is greater during human heart failure than in healthy tissue. Apelin protects against heart failure due to the pyroglutamic form of apelin, [Pyr1]-Apelin-13, which decreases infarct size of myocardial infarctions. Furthermore, rats with hypertension have reduced levels of apelin and APJ. [Pyr1]-Apelin-13 exhibits higher APJ agonist potency than Apelin-13. We also have the alternative available.Fórmula:C69H108N22O16SForma y color:PowderPeso molecular:1,533.8 g/molH-ASFHIPQVQVR^-OH
Peptide H-ASFHIPQVQVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-YNWNSFGLRF-NH2
Peptide H-YNWNSFGLRF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.SARS-CoV-2 NSP13 (551-565)
The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication. NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (551-565) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecular:1,673.8 g/molH-EGMNIVEAMER^-OH
Peptide H-EGMNIVEAMER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Cyclo(-D-Leu-D-Pro)
CAS:Cyclo(-D-Leu-D-Pro) is a macrolide that inhibits the growth of bacteria. It binds to the 50S ribosomal subunit and prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. Cyclo(-D-Leu-D-Pro) has been shown to have antibacterial activity against the Gram negative bacterium Vibrio anguillarum. This drug has also been shown to have endophytic properties, as it was isolated from an endophytic fungus found in leaves of Eucalyptus trees. The stereoisomers of cyclo(-D-Leu-D-Pro) have different effects on bacterial cells, with one being more potent than the other.Fórmula:C11H18N2O2Pureza:Min. 95%Forma y color:PowderPeso molecular:210.27 g/mol(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]penta noyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propan
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Fórmula:C49H70N14O11Peso molecular:1,031.2 g/molTPL-2tide
Tumour progression locus 2 (TPL2) is a mitogen-activated protein kinase kinase (MAP3 K) and is critical for the production of tumour necrosis factor alpha (TNFalpha) in innate immune responses and a potential anti-inflammatory drug target. TPL-2 forms a complex with NF-KB1, p105 and ABIN-2.TPL-2tide is phosphorylated by TPL-2, making TPL-2tide a useful tool for use in kinases assays.Forma y color:PowderPeso molecular:1,858.8 g/mol[5-FAM] EGFR/kinKDR peptide substrate
Peptide substrate of the epidermal growth factor receptor (EGFR), a member of the receptor tyrosine kinase family known as ErbBs or HER receptors. These receptors are involved in the regulation of cell proliferation, survival, differentiation and migration. When these receptors are dysregulated many diseases, including cancer, can arise.Binding to the ligand binding domain of the EGFR causes receptor dimerization. This is sequentially followed by the tyrosine kinase domain being activated and the tyrosine residues on the C-terminal tail of the receptor becoming phosphorylated, activating downstream signalling pathways.This peptide contains an N-terminal 5-Carboxyfluorescein (5-FAM) moiety, a widely used green fluorescent tag.Peso molecular:1,978.9 g/molH-STSGGTAALGCL^VK-OH
Peptide H-STSGGTAALGCL^VK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
GIP (Pro 3)
Gastric inhibitory polypeptide (GIP) is an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion - in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide. In GIP (Pro 3) the glutamic acid at position 3 has been substituted for a proline.GIP is derived from a 153-amino acid proprotein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on β-cells in the pancreas. These β-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM)- studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.
Peso molecular:4,947.5 g/mol
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