Péptidos
Subcategorías de "Péptidos"
Se han encontrado 29624 productos de "Péptidos"
Histone H4 (1-21)
Histone 4 (H4) is one of the four core histones (H2A, H2B, H3 and H4) which are essential for compacting eukaryotic DNA into the nucleosome. Due to the high lysine and arginine content, histones have a net positive charge and therefore electrostatically interact with negatively charged DNA. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Like other core histones, H4 has a globular domain and a flexible N-terminal domain, the histone tail, which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination.Gene transcriptional activation or inactivation is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes. Both processes function to alter the positioning of the nucleosome, allowing the DNA within to be either accessible to the transcription machinery or inaccessible. H4's lysine rich tail plays a role in the higher order chromatin folding.Peso molecular:2,090.2 g/molVisperas2pY
An immunoreceptor tyrosine-based activation motif (ITAM) is a phosphorylation site consisting of a conserved sequence of four amino acids that is repeated twice in the cytoplasmic tails of cell-surface non-catalytic tyrosine-phosphorylated receptors. The major role of ITAMs is its involvement in the initiation of signalling pathway and the subsequent activation of immune cells. The motif has the following structure: YxxL/I. where xx are any two amino acids. Two of these signatures are typically separated by between 6 and 8 amino acids in the cytoplasmic tail of the molecule (YxxL/Ix(6-8)YxxL/I). ITAMs are found in the CD3 and θ¶-chains of the T cell receptor (TCR) complex. TCR is a multi-subunit receptor on the surface of T cells. TCR contains two ligand binding chains containing 20 phosphorylation sites, distributed on 10 ITAMs. The TCR θ¶-chain is a homodimer subunit that contains six ITAMs (12 sites). These sites are phosphorylated by the membrane-anchored Src family tyrosine kinase Lck and Fyn and are dephosphorylated by the transmembrane phosphatases CD148 and CD45. When both tyrosines in an ITAM are phosphorylated they generate docking sites for the tandem SH2 domains of the cytosolic tyrosine kinase ZAP-70. Bound ZAP-70 can phosphorylate tyrosines on other substrates that initiate the signal transduction that leads to T cell activation. The multiple ITAMs on the TCR function mainly to amplify subsequent signalling.T cells rely on the TCR to recognize antigens, in the form of peptides bound to major histocompatibility complexes (MHC), on the surfaces of antigen-presenting cells. Binding of TCR to antigen-MCH complexes leads to proliferation, differentiation, and the secretion of effector cytokines, contributing to the elimination of infections.Peso molecular:2,672.1 g/molApelin-36 Human
CAS:Apelin-36 (human) is derived from the apelin peptide which acts as a ligand for the apelin receptor (APJ) G protein coupled receptor and is a substrate for angiotensin converting enzyme 2. Preprapelin, encoded for by APLN located on Xq25-26.1, is cleaved to form either apelin 36, apelin 17, apelin 13, or apelin 12. As a member of the adipokine hormone family, which are involved in processes such as vascular homeostasis and angiogenesis, apelin is secreted from adipose tissue.Both apelin and the apelin receptor are widely distributed around the body thus apelin has been found to be associated with cardiovascular diseases, obesity, diabetes and cancer. Studies exploring myocardial infarction showed there to be greater apelin mRNA expression during human heart failure compared to in healthy tissue. Apelin protects against heart failure due to, the pyroglutamyl form of apelin, playing a role in decreasing infarct size of myocardial infarctions. Furthermore in rats with hypertension, the expression of apelin and APJ was decreased.Peso molecular:4,193.3 g/molCyclo(CLLFVY)
Cyclo(CLLFVY) is a cyclic peptide which binds to the PAS-B domain of HIF-1alpha, thus inhibiting HIF-1 dimerisation and HIF-1 mediated hypoxia signalling.Peso molecular:738.4 g/molCy5-KAPAR-OH
Peptide Cy5-KAPAR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-V^YIHP^F^HL-OH
Peptide H-V^YIHP^F^HL-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Human Papillomavirus E7 protein (49 - 57)
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C52H77N15O13Peso molecular:1,120.29 g/molLCBiot-AHGVTSAPDTRPAPGSTAPPA-NH2
Peptide LCBiot-AHGVTSAPDTRPAPGSTAPPA-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.TNF-alpha (1-26), human
Peptide derived from tumour necrosis factor alpha (TNF-α), a cytokine produced by macrophages, T lymphocytes and natural killer cells. It exerts its function through targeting the transmembrane receptors TNF receptor 1 and TNF receptor 2, the latter of which it has a higher affinity for. When binding to TNF receptor 1 TNF-alpha is pro-apoptotic and when binding to TNF receptor 2 it is anti-apoptotic. TNF-α has further roles in inflammation, immunity and cancer.Expression of the TNF-α gene, located on chromosome 6 in humans is regulated by factors such as nuclear factor kappa b (NFKB).Dysregulation of TNF-α and its receptors can contribute to diseases such as rheumatoid arthritis, Crohn disease and diabetes. Anti-TNF-α can be used as a therapeutic agent to target TNF-α during inflammatory diseases.Peso molecular:2,729.4 g/molH-LTQLGTFEDHFLSLQR^-OH
Peptide H-LTQLGTFEDHFLSLQR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[5-FAM]-SRC Substrate Peptide
Substrate peptide for Scr, tyrosine kinase, for use in in vitro assays for Src activity.Src is a member of the Src Family tyrosine Kinases (SFKs), a large cytosolic, non-receptor, kinase family that controls multiple signalling pathways in animal cells. Src is a tyrosine kinase proto-oncogene and elevated levels of Src protein are seen in different tumours including: breast- lung- thyroid- glioblastoma- colorectal- pancreatic- prostate- gastric- biliary tract and skin cancer. Src levels are often associated with tumour progression, metastasis, and a poor clinical outcome and therefore Src has been investigated as a therapeutic target.Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:2,027.94 g/moln-Octylpolyoxyethylene
CAS:n-Octylpolyoxyethylene (n-OPEO) is a synthetic surfactant that is used as an antimicrobial agent. It has been shown to be effective against a wide variety of bacteria, including Mycobacterium tuberculosis and Staphylococcus aureus. The mechanism by which n-OPEO exerts its antibacterial efficacy is not yet fully understood. It may inhibit the growth of bacteria by disrupting their cell membranes, or it may interfere with the synthesis of proteins needed for bacterial growth.Fórmula:C8H18O(C2H4O)nForma y color:Clear LiquidPeso molecular:174.28H-LSGFGNFDLR^-OH
Peptide H-LSGFGNFDLR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Biotin TAT (48-60)
Biotin TAT (48-60) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). The 48-60 region of the TAT peptide is an arginine-rich bascic domain which as a whole has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.This peptide has a covalently bonded N-terminal Biotin tag that can be used for detection and purification and contains an N-terminal aminohexanoic acid spacer (Ahx).Peso molecular:2,057.2 g/molH-NSILTETLHR^-OH
Peptide H-NSILTETLHR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-DAVTYTEHAK^-OH
Peptide H-DAVTYTEHAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Ac-AGRSL-NH2
Peptide Ac-AGRSL-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
VIP (guinea pig)
Vasoactive intestinal peptide (VIP) is a neuropeptide found throughout the body and the central nervous system. VIP is located within cell bodies and nerve endings of the enteric nervous system, brain and pancreas. VIP neurons in the peripheral system fire to regulate blood vessels, and the CNS innervate cerebral vasculature. VIP binds to G protein-coupled receptors VPAC1 and VPAC2. VIP and VPAC2 are detected in circular smooth muscle cells of cerebral arterioles. VIP and VPAC1 are also found in lymphatic tissue. VIP can block inflammation, modify the Th response favouring Th2 and induce regulatory T cells. Overexpression of each receptor has been linked to various cancers.VIP administration leads to pancreatic bicarbonate-rich fluid secretion but not to the same degree stimulated by secretin. VIP stimulates insulin secretion in a glucose-dependent manner and also stimulates glucagon secretion. Studies have found that in morbidly obese patients, VIP levels are lowered and work to slow gastric and duodenal motility but increase gastric emptying. Therefore, decreasing VIP levels in obese patients may increase weight gain by accelerating gastric emptying.VIP has been well studied in pancreatic acini. VIP is a full agonist of amylase secretion and increases cyclic AMP synchronised with an increase in intracellular Ca2+ triggered by stimuli that act through cholecystokinin (CCK) or cholinergic agonists. Most cAMP increases and amylase secretion appears to be mediated via VPAC1.
Peso molecular:3,342.7 g/molH-Dab-Pip
H-Dab-Pip is a peptidase inhibitor that inhibits the enzyme known as dipeptidyl peptidase. It also inhibits the enzyme known as dipeptidyl peptidase, which is involved in the breakdown of dipeptides. H-Dab-Pip is an inhibitor of this enzyme and can be used to regulate blood pressure by inhibiting the breakdown of angiotensin II, a potent vasoconstrictor. H-Dab-Pip may also be used for diabetes treatments or for the treatment of inflammatory bowel disease.Fórmula:C9H19N3OPureza:Min. 95%Peso molecular:185.27 g/mol
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