Péptidos

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Neuromedin U is a peptide that plays a role in the regulation of cardiovascular function and the modulation of pain. It has been found to activate receptors for calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP). Neuromedin U has also been found to be an inhibitor of ligand-induced activation of ion channels, such as those activated by bradykinin or histamine. This protein can be used as a research tool in cell biology, pharmacology, and biochemistry.

AC 253 is an amylin (AMY3) receptor antagonist.

TRAIL is a peptide that belongs to the group of cytokines. It activates the receptor-mediated apoptosis pathway in cells that have been stimulated by tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines. TRAIL has also been shown to inhibit protein interactions, such as those between the TNF receptors and their ligands or receptors, like CD4. TRAIL also binds to the Fas receptor and its ligand, FasL, which leads to activation of caspases in a similar manner as FADD binding. The recombinant human TRAIL is a research tool for studying cell biology and pharmacology.

Neuromedin B is a neuropeptide that is found in the central nervous system and peripheral tissues. It activates ligand-gated ion channels, including nicotinic acetylcholine receptors. Neuromedin B has been shown to inhibit the activity of voltage-gated potassium channels and calcium channels, which are involved in neurotransmission. It also inhibits the activation of phospholipase C, which is involved in cellular signaling pathways. This peptide can be used as a research tool for studying the pharmacology of peptides and as an antibody for immunohistochemistry studies.

TentaGel is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix. The TentaGel S base resins are available with several different derivative choices. The typical capacity range for our TentaGel base resins is 0.2-0.3 meq/g.
Application: (90 µm)
Substitution Functional Group:-CH2-CH2-SH

The ALB, GIG20, GIG42 MS Calibrator (25nmol) is a Proteomics Tools product that has been designed to support the identification of biologically active peptides in proteomics. The ALB, GIG20, GIG42 MS Calibrator (25nmol) is a tryptic peptide derived from human serum albumin and can be used as a precursor for the identification of other tryptic peptides in proteomic samples. The New England Peptide Company offers this product at a competitive price and with high quality.

Magainin 1 is a research tool that belongs to the class of activators. It binds to receptor and ligand, which are proteins in cells. Magainin 1 is used as a tool in cell biology to study protein interactions and pharmacology, as well as for the study of ion channels. It has high purity and can be used with other reagents, such as antibodies or peptides, in research.

This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.

Polystyrene is a thermoplastic polymer that is used in the production of polystyrene resins, which are used as building blocks for peptide synthesis. New England Peptide offers a variety of polystyrene resin products including particle resins and Rapp Polymere resins. The particle size of the resin ranges from 5-100 µm. Polymers can be synthesized using various methods including solid-phase synthesis and solution phase synthesis, which both require polystyrene resins. This product is available with a variety of functionalities, such as amine, hydroxyl and carboxyl groups.

Azido-dPEG®8-OH is a PEG polymer categorised as monofunctional (OH-PEG-X). Used as a linker, Aazido-dPEG®8-OH is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.

IL-15 is a cytokine that belongs to the IL-2 family and is produced by activated T cells. IL-15 binds with high affinity to the IL-15 receptor, which then signals through the JAK/STAT pathway. IL-15 has been shown to activate NK cells and stimulate their production of IFNγ. In addition, IL-15 has been shown to cause activation of certain B cells, which leads to increased antibody production. This cytokine also stimulates proliferation of CD4+ and CD8+ T cells and induces differentiation into Th1 or cytotoxic T cell subsets.

Cortistatin is a peptide that belongs to the group of activators. It is a high-purity product with an amino acid sequence identical to cortistatin (rat). Cortistatin activates ion channels, which may be due to its ability to bind to receptors and ligands. This product can be used in life science research or cell biology experiments as an inhibitor or as a tool for protein interactions. The CAS number for this product is 937031-00-0.

MAL-dPEG®4-Glu(OH)-NH-m-dPEG®24 is a peptide containing polyethylene glycol (PEG) as spacer to alter their pharmacokinetic properties and pharmodynamics.

Bis-dPEG®4-TFP Ester is a PEG polymer categorised as homobifunctional PEG (X-PEG X). Used as a linker, bis-dPEG®4-TFP Ester is used to attached PEG to proteins, peptides, oligonucleotides, nanoparticles and small molecules via pegylation, a bioconjugation technique.

Rituximab is a chimeric monoclonal antibody used in the treatment of some cancers like CD20 non-Hodgkin's lymphoma and a few autoimmune conditions such as rheumatoid arthritis. However, antibody treatment can lead to generation of neutralising antibodies thus curtailing the efficacy of the therapy. CD 4+ T cells are critical to initiate antibody response so identification of epitopes within molecules using T cell assays can be a vital tool for understanding the immune response and thereby prevent induction of neutralising antibodies. Within rituximab, the variable region of the light chain (41-55) was found to have strong affinity for leukocytes in a specific binding assay, the epitope was also correlated to patients who developed neutralising antibodies. This T cell epitope within rituximab in further immune studies could help design or selection of antibodies without T cell epitopes present for low immunogenicity.

Alyerserin-2b is a C-terminally α-amidated 17 residue cationic anti-microbial peptide (AMP). Anti-microbial peptides (AMPs) are produced by the innate immune system and are expressed when the host is challenged by a pathogen. The Alyerserin family of peptides was first identified in norepinephrine-stimulated skin secretions of the midwife toad-Alytes obstetricans-(Alytidae). Alyteserin-2a, 2b and -2c show some sequence identity with bombinin H6, a peptide from the skins Bombinatoridae family of frogs.Alyteserin-2b is most potent against the Gram-positive bacteria-Staphylococcus aureus and has weak haemolytic activity against human erythrocytes.Alyteserin contain at least 50% hydrophobic amino acids. Hydrophobic residues contribute to the insertion of the peptide into the hydrophobic membrane core which results in membrane disruption and death of the pathogen. Due to their mechanism of action it is thought to be less likely for resistance to develop towards them compared to conventional antibiotics. Alyteserin-2b has a low probability of adopting a helical conformation unlike related Alyteserin-2 peptides.