Péptidos

A synthetic peptide for use as a blocking control in assays to test for specificity of MPZL1 antibody, catalog no. 70R-6628

MiniAP-4 peptide is a short nontoxic derivative of apamin (a neurotoxin from bee venom) used as a blood-brain barrier (BBB) shuttle peptide.

KLPGF peptide is a sequence from egg white albumen. This peptide have recently shown interest for Alzheimer’s disease.

Biotin-NY-ESO-1 (157-165) – General analog epitope of tumor cells

Biotin-SARS-CoV-2 Spike RBM 450-473 peptide is the biotinylated version of SARS-CoV-2 Spike RBM 450-473 peptide. SARS-CoV-2 Spike RBM 450-473 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Motif (RBM). Biotin-SARS-CoV-2 Spike RBM 450-473 peptide is useful for vaccine development and for structure-activity relationship studies
SARS-CoV-2 Spike (S) glycoprotein
Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.
With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.
SARS-CoV-2 Spike RBM:
The receptor-binding domain in SARS-CoV-2 Spike protein contains a receptor-binding motif RBM. SARS-CoV-2 Spike RBM is the main functional motif in RBD and allows contacts between the S protein and the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.

Osteocalcin (OC) is a bone-specific protein that plays important roles in bone metabolism. It is involved in the regulation of bone mineralization and turnover, as well as the formation of new bone matrix. The OC protein is a member of the family of bone regulatory proteins, which includes osteopontin and sclerostin. It interacts with many other proteins such as ion channels, receptors, and ligands. This antibody has been used to identify OC protein interactions with these proteins. It can be used for research purposes in pharmacology or cell biology applications.

A synthetic peptide for use as a blocking control in assays to test for specificity of SLC5A4 antibody, catalog no. 70R-1794

A synthetic peptide for use as a blocking control in assays to test for specificity of ZFYVE19 antibody, catalog no. 70R-8903

Kv and SK channels blocker

Synthetic peptide toxin derivative of; M-lycotoxin from the Carolina wolf spider, Hogna carolinensis. This peptide can be used for transport into the cytoplasma and is available as a 0.5mg vial.

m-dPEG®48-NH-CO(CH2)3CO-TFP Ester is a PEG compound with two different functional groups (also known as heterobifunctional). Unlike homobifunctional PEG compounds (same functional group on both ends), this type of compounds are more versatile as have two different anchor points. m-dPEG®48-NH-CO(CH2)3CO-TFP Ester is used as a linker and spacer to add a PEG moiety, via pegylation (a bioconjugation technique) to proteins, peptides, oligonucleotides, small molecules and nanoparticles.

Blocker of Kv2 channels

Bz-DL-Arg-pNA • HCl [DL-BAPA] is a trypsin and trypsin-like protease substrate. It is used as a tool in biochemical studies to investigate the degradation of proteins by these enzymes. Bz-DL-Arg-pNA • HCl [DL-BAPA] is also used as an experimental model for diseases that affect enzyme activity, such as rheumatoid arthritis and multiple sclerosis.

Biotin-SARS-CoV-2 Spike RBD 348-357 peptide is the biotinylated version of SARS-CoV-2 Spike RBD 348-357 peptide. SARS-CoV-2 Spike RBD 348-357 peptide is an epitope of interest of the SARS-CoV-2 Spike S glycoprotein Receptor-Binding Domain (RBD). Biotin-SARS-CoV-2 Spike RBD 348-357 peptide is useful for vaccine development and for structure-activity relationship studies
SARS-CoV-2 Spike (S) glycoprotein
Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells.
With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane.
SARS-CoV-2 Spike RBD:
The receptor-binding domain in SARS-CoV-2 Spike protein allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry.

Clickable Arg9 peptide.

Secondary SIL peptide for Dupilimab detection and quantification

Bombesin (BBN) is a 14-amino acid neuropeptide originally isolated from the skin of Bombina bombina. The bombesin-related family comprises three other peptides, the amphibian homologs alytesin and Neuromedin C (NMC), and the mammalian peptide named Gastrin-Releasing Peptide (GRP). Bombesin and bombesin-related peptides are characterized by a region of homology at the carboxy-terminus ending with Gly-His-Leu-Met-NH2, in which resides their biological activity.
Bombesin is active in mammals and affects a broad range of biological functions including smooth muscle contraction, cell growth, blood pressure, plasma glucose, as well as gastric secretions2. These effects are mediated by the interaction of Bombesin peptide with G protein-coupled receptors (GPCRs) called bombesin receptors that are well represented in the gastrointestinal tract and in the central nervous system (CNS).
Bombesin peptide is a potent natural agonist of the mammalian Gastrin Releasing Peptide Receptor (GRPR) also know as bombesin receptor 2 (BB2), whose endogenous ligand is the Gastrin Releasing Peptide (GRP). Bombesin has demonstrated a high affinity for human Gastrin-Releasing Peptide Receptors (hGRPR) in both human cells containing native GRP receptors and murine cells stably expressing human GRP receptors (IC50 = 0.17±0.01 nM and 0.07 ± 0.01 nM, respectively).There is increased interest in targeting the bombesin receptors to explore their roles in pathophysiological processes, and for diagnostic imaging of human cancers over-expressing Gastrin-Releasing Peptide Receptors (GRPR), such as prostate, breast, and small-cell lung carcinoma. Bombesin peptide is investigated as targeting peptide to deliver radiotracers and therapeutic agents into tumors. Moreover, many synthetic agonist analogs of the biologically active COOH terminus of bombesin-related peptides have been synthesized to develop more metabolically stable and selective ligands for Bombesin receptors.

BNP-32 is a peptide that is an activator of the B2 receptor. It has been shown to inhibit the ion channels in cells, which may be due to its binding to the ligand-binding site on the receptor. BNP-32 has also been shown to bind to antibodies and can be used as a research tool for cell biology or other areas of life science. BNP-32 is a high purity product with CAS No. 123337-89-3.

α9α10 and α7 nAChRs channels discrimination

3x DYKDDDDK peptide, also called 3x FLAG peptide, is a 23 aa length peptide used for the competitive elution of DYKDDDDK-tag fusion proteins (with excess of free 3x DYKDDDDK peptide) under non-denaturing conditions, especially when a DYKDDDDK-tagged protein is sensitive to low pH.