Péptidos
Los péptidos son cadenas cortas de aminoácidos unidas por enlaces peptídicos, que desempeñan papeles importantes como moléculas biológicas en los procesos celulares. Funcionan como hormonas, neurotransmisores y moléculas de señalización, y se utilizan ampliamente en aplicaciones terapéuticas y diagnósticas. Los péptidos también son cruciales en la investigación para estudiar las interacciones de proteínas, actividades enzimáticas y vías de señalización celular. En CymitQuimica, ofrecemos una amplia selección de péptidos de alta calidad para apoyar sus necesidades de investigación y desarrollo en biotecnología y farmacéutica.
Subcategorías de "Péptidos"
Se han encontrado 29608 productos de "Péptidos"
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[Glu4]-Oxytocin
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C43H65N11O13S2Peso molecular:1,008.17 g/molCBL-B (22-37) Light
CBL-B (22-37) is derived from the CBL-B E3 ubiquitin ligase which targets receptor tyrosine kinases to lysosome degradation. CBL-B and its family member CBL are expressed in hematopoietic cells and as E3 ubiquitin ligases they contain a tyrosine kinase domain and an RF domain joined by a linker domain. The function of the RF domain is to transfer ubiquitin from E2 ubiquitin-conjugating enzymes onto the target protein which is often phosphorylated. Consequently the ubiquitinated substrate, the receptor tyrosine kinases, are ultimately targeted to the lysosome for degradation.EGFR is an example of a receptor tyrosine kinase whose activation is prevented by CBL and CBL-B when they bind and recruit GRb2, the adapter protein to EGFR. Consequently the ubiquitinylation of EGFR occurs and targets it for recognition by the endosomal protein complex and then lysosome degradation.It has also been found that the CBL family can negatively regulate through ubiquitinylation, PI 3-kinases, Rap G-protein guanine nucleotide exchange factor (GEF), C3G and Rho GTPase GEF Vav which are all non-receptors.If CBL or CBL-B becomes non-functional it can be associated with malignancies such as acute myeloid leukemia and myelodysplastic syndrome.Peso molecular:1,618.9 g/molAc-FYWHCLDE-OH
Peptide Ac-FYWHCLDE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.TAT (48-59) amide
Biotin-Tat (47-57) is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a trans-activator of the transcription protein present in the human immunodeficiency virus (HIV). Specifically Biotin-TAT (47-57) is located within the arginine-rich basic domain 48-60 of the TAT peptide which as a whole has three domains which function to aid HIV through transactivation, DNA binding and nuclear transport. As a cell penetrating peptide (CPP) TAT aids in the cellular uptake of molecules and hence serves a valuable purpose in transduction methods. This property has been demonstrated through its ability of allowing toxins such as the neurotoxin Botulinum neurotoxin Type A, produced by the Clostridium botulinum type A bacteria to penetrate the skin barrier non-invasively.This peptide has an uncharged C-terminal amide.Peso molecular:1,589 g/molPresenilin-1 (S182 Protein) (431-467) (Human)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolPeso molecular:4,299.09 g/molBuforin II
CAS:Buforin II is a highly potent antimicrobial peptide which was derived from buforin I, a peptide isolated from the stomach of the Asian toad, Bufo bufo garagrizans. Buforin II is an alpha-helical antimicrobial peptide, however it has far stronger antimicrobial activity against a broad spectrum of microorganisms compared with other alpha-helical antimicrobial peptides. Buforin II may have a different mode of action to that of other alpha-helical peptides targeting nucleic acids instead of cell membranes.Fórmula:C106H184N40O26Forma y color:PowderPeso molecular:2,434.85 g/molBiot-KTWGQYWQV-OH
Peptide Biot-KTWGQYWQV-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
CRF (human, rat)
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C208H344N60O63S2Peso molecular:4,758 g/molH-RV^YIHP-OH
Peptide H-RV^YIHP-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Aoa-HHHHHHHHHHHHHHHHHHHH-NH2
Peptide Aoa-HHHHHHHHHHHHHHHHHHHH-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[Sulfo-Cyanine5]-Val-Pro-Valp(OPh)2
Boc-Val-Pro-ValP(OPh)2 is a good inhibitor for HLE (Human Leukocyte Elastase) and porcine pancreatic elastase (PPE).Peso molecular:1,379.7 g/molH-ESSSHHPGIAEFPSR^-OH
Peptide H-ESSSHHPGIAEFPSR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Ac-WDWDWDWDWDWDWDWDWDWD-NH2
Peptide Ac-WDWDWDWDWDWDWDWDWDWD-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.IFNB1 (118-132) Human deimmunised
Recombinant human interferon-β (IFNB) is a therapeutic for specific stages of multiple sclerosis (MS). However, a significant portion of patients develop neutralising antibodies within two years which prevent the clinical efficacy of the treatment- this was correlated to a specific rise in IgG. Sequencing of IFNB1 revealed CD4+ T cell epitope residues (118-132) that contain critical T cell activation residues. Identifying these sequences allows them to be manipulated to provide new interferon treatments that reduce the capacity to induce neutralising antibodies in MS patients. In addition, the critical residue isoleucine has been mutated to valine and shown to reduce the immunological response to this epitope. This IFNB1 (118-132) epitope can be used for immunological investigations as a deimmunised version of the epitope. In addition, it can be used as a control for T cell activation and antibody recognition via immunoassays and immunohistochemistry. This may provide further insights into specific haplotypes correlating to IFNB responses in MS treatment.Peso molecular:1,891 g/molPAR-2 Agonist amide
Thrombin receptor inhibitory peptide (TRIP). Thrombin activates members of the PAR family of receptors to initiate a variety of signalling pathways.Protease activated receptors (PARs) are a distinctive four-member family of seven transmembrane G protein-coupled receptors (GPCRs) widely expressed in inflammatory cells. PARs are cleaved by certain serine proteases to expose a tethered ligand domain, this ligand domain then binds to and activates the receptors to initiate multiple signalling cascades. This peptide mimics the tethered peptide ligand of PAR- 2, but lacks the S42 residue which is important for receptor activation, and therefore acts as a thrombin antagonist peptide.Forma y color:PowderPeso molecular:1,297.7 g/molPA protein (Influenza A virus)
The PA protein is a subunit of the influenza virus polymerase complex and its endonuclease activity is vital in viral genome replication. As a phosphoprotein it is a casein kinase substrate and its N-terminus is responsible for the activation of a proteolytic process in which co-expressed proteins are degraded.During viral RNA synthesis PA produces 5' capped RNA oligonucleotides due to it cleaving the 5' terminus on pre-mRNA. It is possible that the PA protein could be used as a target in antiviral chemotherapy.Peso molecular:1,054.6 g/molBiotin Apolipoprotein A-I (APOA1)(86-101)
Apolipoprotein A-I enables the efflux of fat molecules from within cells as high-density lipoprotein (HDL) particles for transport back into LDL particles or to the liver for excretion. HDLs are one of five major groups of lipoproteins. Increasing concentrations of HDL particles are strongly associated with decreasing accumulation of atherosclerosis within the walls of arteries. Apolipoprotein A-I is often used as a biomarker for prediction of cardiovascular diseases, such that low levels of APOA1 are associated with an increased risk of adverse events in patients with coronary artery disease. In such cases, APOA1 can be used as a biomarker to predict cardiovascular disease progression.This peptide contains a covalently bonded N-terminal Biotin tag that can be used for detection and purification.Peso molecular:2,157 g/molH-VFIGVNDLER^-OH
Peptide H-VFIGVNDLER^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.Amylin (1-37) Human
Amylin, also known as islet amyloid polypeptide (IAPP), is a peptide hormone which is deficient in patients with diabetes mellitus (DM). Amylin is co-secreted with insulin from the pancreatic β-cells. It inhibits glucagon secretion, delays gastric emptying, and thus acts as a satiety agent. Amylin peptide is capable of forming aggregates, and pancreatic amyloid plaques are present in 90% of patients with DM. Formation of these plaques may be inhibited by insulin via the formation of heteromolecular complexes. Amylin is also involved in adiposity signalling and body weight regulation.Amylin is expressed in the human placenta during pregnancy where it may help regulate food intake by both the mother and foetus, and is involved in foetal development of bone, kidneys and pancreas.Forma y color:PowderPeso molecular:3,901.85 g/molIDR 1002
Synthetic host defence peptide derivative with strong anti-inflammatory properties.
Peso molecular:1,651 g/molH-PPGFSPFR^-OH
Peptide H-PPGFSPFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.(Asn²³)-Amyloid β-Protein (1-40)
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Fórmula:C194H296N54O57SPeso molecular:4,328.88 g/molAF10847
Activation of the inflammatory response is critical to various infectious agents. Pro-inflammatory cytokines like-IL-1α and IL-1β are upregulated upon the initial detection of infection and bind to IL-1R1 to activate the signalling cascade. However, a hyperinflammatory response can lead to oxidative stress, apoptosis, and conditions such as diabetes, rheumatoid arthritis, cancer, and ischemia.To maintain homeostasis there are moderators of the inflammatory response. Binding of interleukin IL-1 to IL-1R1 stimulates the inflammatory cascade. Alternately, AF10847 binds to IL-1R1 resulting in significant conformational change of IL-1R1 but its lack of any cytokine activity locks IL-1R1 in an inactive state inhibiting a signalling event. AF10847 has an exceedingly high affinity for IL-1R1 compared to 1α and IL-1β.Extensive searches for lower molecular mass IL-1R antagonists-for oral delivery as a therapeutic for rheumatoid arthritis are being carried out. AF10847 is a 21-mer that has high affinity for the conserved IL-1R1 binding site that is also recognised by IL-1β. The remarkable high affinity of AF10847 for IL-1R1 makes it a perfect candidate for further investigations into novel IL-1R1 inhibitor development.Forma y color:PowderPeso molecular:2,604.2 g/molInfluenza A NP (44-52) (HLA-A1)
Influenza A NP (44-52) (HLA-A1) is a CEF control peptide that is derived from Influenza A. Influenza A is an enveloped negative-strand RNA virus that is capable of interfering with host transcription, which can ultimately cause cell death. The action of the virus particles decreases the downstream gene occupancy of RNA polymerase II, as well as instigating cellular stress, resulting in the failure of polymerase II termination at poly(A) sites. Influenza A NP (44-52) (HLA-A1) is defined as a CEF control peptide due to its antigenic properties. Clinically, this peptide is a suitable epitope for CD8+ T cells and can be used to stimulate the release of IFNg. HLA-A1 refers to the cell HLA type that this peptide acts on.The nucleoprotein (NP) is a structural protein that encapsulates the negative strand of viral RNA. NP plays a critical role in the transition of influenza virus RNA synthesis from transcription mode to replication mode.Peso molecular:1,070.5 g/molSARS-CoV-2 NSP13 (581-595)
The SARS-CoV-2 non-structural protein 13 (NSP13) has been identified as a target for anti-viral therapeutics due to its highly conserved sequence and is essential for viral replication. NSP13 is part of the helicase superfamily 1B. As an NTPase and RNA helicase, NSP13 binds to RNA-dependent RNA polymerase and acts in concert with the replication-transcription complex to stimulate backtracking and further activate NSP13 helicase activity. These factors make NSP13 a good target for developing new antiviral drugs. In addition, the identification of epitopes within the NSP13 sequence can help design more effective SARS-CoV-2 vaccines.Models have predicted epitopes exhibiting antigenicity, stability and interactions with MHC class-I and class-II molecules. NSP13 (581-595) is an epitope candidate with various HLA restrictions. This epitope can be used to better vaccine design for more durable CD4+ and CD8+ T cell responses for long-lasting immunity.Peso molecular:1,878 g/molMBP Ac1-9
The acetylated N-terminal peptide of murine myelin basic protein (MBP) (1-9).Forma y color:PowderPeso molecular:1,098.22 g/molH-WLPSLVLAR^-OH
Peptide H-WLPSLVLAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
[Cys]-Galanin (1-30) Human
Galanin (1-30) is an endogenous neuropeptide with endocrine, metabolic and behavioural effects. Galanin has a role in intestinal smooth muscle contraction, insulin and somatostatin release, and synaptic neurotransmission.Galanin is widely distributed in the central nervous, peripheral, and endocrine systems. Galanin's overarching function is as an inhibitory, hyper-polarizing neuromodulator for classical neurotransmitters like acetylcholine and serotonin. Galanin interacts with 3 receptor subtypes, GalR1-3 G protein-coupled receptors inserted into the plasma membrane. GalR1 is believed to activate a Gβγ pathway to regulate MAPK activation. GalR2 can also activate the MAPK pathway, but unlike GalR1, there is detectable inositol phosphate production. GalR3 is associated with the G alpha i/o pathway receptor activation leads to a cellular influx of K+. Each receptor has been associated with neurological diseases such as GalR3 and epilepsy.Galanin protects against various physiological insults in vitro, including excitotoxicity and β-amyloid toxicity. Changes in galanin have been widely studied concerning Alzheimer's disease, and galaninergic neurons are spared in late-stage Alzheimer's relative to non-galaninergic neurones.Galanin (1-30) has been used as an agonist for the GalR2 receptor in vitro for calcium mobilisation assays to understand the role Galanin/GalR2 play in multiple sclerosis.An N-terminal cysteine residue has been included on the galanin (1-30) peptide to allow ease of site-specific conjugation to various molecules.Peso molecular:3,258.6 g/molFibromodulin F4 226-235 (HLA-A*02:01)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
H-FQNALLVR^-OH
Peptide H-FQNALLVR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.CREBtide
CAS:Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolFórmula:C73H129N29O19Peso molecular:1,717 g/mol(Tos-YASR)2-[Rh110]
Optimal peptide substrate for kallikrein-related peptidase 14 (KLK14). In its intact state this peptide is not fluorescent, however when this substrate peptide is cleaved by KLK14, Rhodamine 110 is released and thus fluorescence can then be detected. This peptide therefore allows for the quantification of KLK14 peptidase activity. KLK14 is most abundant in the skin, with lower levels in breast and prostate and may form part of the protease cascade responsible for maintaining the epidermal barrier. Aberrant KLK14 proteolytic activity is linked to several skin pathologies. Overexpression of KLK14 seen in several hormone-dependent cancers, including prostate, colon, ovarian, and breast, correlating with higher risk of disease progression. Therefore KLK14 is a potential point of therapeutic intervention in a variety of pathologies.Contains rhodamine 110 group, a widely used red fluorescent tag. The terminal carboxylic acids in this peptide have been activated by the addition of the p-tosyl moiety, allowing for easy addition of functional groups or further peptide residues.Peso molecular:1,592.6 g/molBiotin-β-Amyloid (1-15) human
β-Amyloid 1-15 (Aβ1-15) is one of many short Aβ species found in vivo and is formed by the cleavage of amyloid β precursor protein by β- and alpha-secretase.Amyloid β-protein (Aβ) has been identified as the key subunit of the extracellular plaques found in the brains of patients with Alzheimer's disease (AD) and Down's syndrome (DS). Aβ has therefore been extensively studied as a potential target for treatment of AD.Aβ is formed from the cleavage of the large, transmembrane protein- APP (amyloid precursor protein). Cleavage of APP by β- and then γ-secretases results in the formation of Aβ. Aβ can aggregate to produce amyloid-β oligomers, which are thought to be highly neurotoxic. Over time Aβ can further aggregate to produce the characteristic senile plaques present in AD and DS. Aβ can be degraded by enzymes such as neprilysin, insulin degrading enzyme or endothelin converting enzyme. At physiological levels Aβ may be involved in controlling synaptic activity and neuronal survival.This peptide contains a covalently attached N-Terminal biotin tag for convenient detection and purification.Peso molecular:2,052.8 g/molERAAP substrate Ep
Ep is a peptide-based fluorescent probe that can detect the intracellular amino-peptidase- ER aminopeptidase associated with antigen processing (ERAAP). ERAAP cleaves peptides presented by major histocompatibility complex (MHC) class I molecules to determine which are displayed on cell surfaces for T cell recognition. Down-regulation of ERAAP alters these cell surface peptides resulting in the cell being recognised as foreign. Therefore ERAAP is a potential target for increasing the immune response towards tumours. Down-regulation of ERAAP is also implicated in auto-immunity.Ep contains the fluorescent dye BODIPY and the fluorescent quencher dinitrophenyl (DNP), conjugated to the KK-SIINFECL peptide which is based on a known ERAAP-substrate. Ep initially has low fluorescence due to the proximity of the DNP quencher, however after ERAAP cleaves the N-terminal amino acid of Ep and releases the DNP quencher, a dramatic 20 fold increase in fluorescence is seen.Ep can detect ERAAP in cells in a highly sensitive and specific manner. Ep can detect ERAAP activity in live cells and in high-throughput-screens (HTS), and can compete with endogenous cellular substrates for ERAAP.Peso molecular:1,773.7 g/molSIVmac239 - 29
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,574.8 g/molH-SLDNGGYYISPR^-OH
Peptide H-SLDNGGYYISPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
H-VTVFPIGIGDR^-OH
Peptide H-VTVFPIGIGDR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.N-methylated ERAP1substrate
Non-hydrolysable ERAP1 substrate. An optimized ERAP1 substrate with N-methylation of the first amide bond to prevent its degradation by ERAP1.Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are ER-resident, interferon-γ inducible, metalloaminopeptidase which critically shape the major histocompatibility complex I (MHC I) immunopeptidome. The ERAPs remove N-terminal residues from antigenic precursor peptides and generate optimal-length peptides (i.e. 8-10-mers) to fit into the MHC class I groove. The immune recognition of surface MHC I/peptide complexes initiates activation of CD8+ T cells as a critical step in the elimination of pathogens.ERAP1 has unique substrate preferences, trimming long peptides while sparing shorter ones as well as sequence preferences. ERAP1 and ERAP2 can form a heterodimer (ERAP1/ERAP2) with distinct functional properties. Allelic variants of ERAP1 have been linked to a number of human diseases, including the autoimmune disease ankylosing spondylitis (AS), diabetes, some forms of cervical cancer, and hypertension.Forma y color:PowderPeso molecular:1,035.6 g/molH-DIEVQGFR^-OH
Peptide H-DIEVQGFR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-LLFNK^VTLA-OH
Peptide H-LLFNK^VTLA-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
Biot-RRRVTSAARRS-NH2
Peptide Biot-RRRVTSAARRS-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.HXB2 gag NO-68
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool
Peso molecular:1,692.1 g/molProto-oncogene PIM1 (191-199)
Custom research peptide; min purity 95%. For different specs please use the Peptide Quote ToolCRF human, rat
The peptide CRF, also known as the Corticotropin Releasing Factor is a 14 amino acid neuropeptide which is produced by the hypothalamus, within the hypothalamic-pituitary adrenal axis in response to stress stimuli. The CRF family exert their function by binding to Corticotropin-releasing factor receptors 1 and 2. During stress the production of CRF stimulates downstream hormones such as glucocorticoids and adrenocorticotropin (ACTH) through binding to CRF1 in the anterior pituitary gland. A negative feedback look is generated through glucocorticoids thus preventing the further release of CRF from the hypothalamus.Studies have shown CRF to be overproduced in patients with depression and can contribute to symptoms such as, reduced quality of sleep, anxiety, reduced appetite and analgesia. Furthermore higher CRF levels has been associated with immune cell dysfunction through preventing T-cell proliferation.Forma y color:PowderPeso molecular:4,754.5 g/molHistone H3 (1-20) pT3, K4Me3-GG-[Lys(5-FAM)]
Histone 3 (H3) is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into the nucleosome. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.The lysine at position 4 of this peptide has been tri-methylated and it is implicated in studies that this modification may remodel the chromatin so that it is more accessible to transcription factors, which may ultimately increase the level of gene expression. Moreover, the threonine at position 3 has been phosphorylated. It is implicated in recent studies that H3T3 phosphorylation regulates chromosome cohesion and is necessary for chromosomes to be able to align on the metaphase plate.The this peptide is labelled with 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.
Peso molecular:2,904.5 g/molH-GGEAAEAEAEKC-NH2
Peptide H-GGEAAEAEAEKC-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.H-GHIISLK^-OH
Peptide H-GHIISLK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.
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