Endotoxin Inhibitor

CAS: 147396-10-9

Ref. 01-4014453

Información del producto

• Nombre: Endotoxin Inhibitor
• Sinónimos: K-T-K-C-K-F-L-K-K-C, H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH (Disulfide bond), H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-Oh
• CAS: 147396-10-9

Descripción

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 107 M-1. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases. KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.

• Marca: Bachem

Propiedades químicas

• Peso molecular: 1224.6
• Fórmula: C₅₅H₉₇N₁₅O₁₂S₂
• Pureza: 98.8%
• Color/Forma: White Powder