BIBP3226

CAS: 159013-54-4

Ref. 01-4034548

Información del producto

• Nombre: BIBP3226
• Sinónimos: BIBP 3226, (2R)-5-(Diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(4-hydroxyphenyl)methyl]pentanamide, Benzeneacetamide,N-[4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-a-phenyl-, (R)-, Bibp 3226, N-[(1R)-4-[(Aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenylbenzeneacetamide, Benzeneacetamide, N-[(1R)-4-[(aminoiminomethyl)amino]-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl]-α-phenyl-

Descripción

The Y₁ receptor antagonist BIBP-3226, a derivative of D-arginine, binds to the Y₁ receptor with high affinity (its Ki was 7 nM versus the Ki of 0.2 nM for NPY). BIBP3226 also reduced the NPY-induced increase in intracellular calcium as well as the pressor response in vitro and in vivo. BIBP3226 inhibited NPY induced feeding in rats. In dogs, intra-arterial infusion of BIBP-3226 interrupted tonic NPY Y1 receptor-mediated vasoconstriction in exercising skeletal muscle, resulting in substantial increases in experimental limb blood flow. CAS-Number (trifluoroacetate): 1068148-47-9.

• Marca: Bachem

Propiedades químicas

• Peso molecular: 473.58
• Fórmula: C₂₇H₃₁N₅O₃
• Pureza: 98.8%
• Color/Forma: White Powder