Información del producto
The abundance of Cdc25A fluctuates periodically during the cell division cycle, which is primarily modulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, Anaphase Promoting Complex/Cyclosome and Skp1/Cul1/F-box protein. Ubiquitylation and degradation occurs at mitotic exit and in G1 due to the presence of a destruction motif (KEN-box) in Cdc25A, while phosphorylation events regulate Cdc25A protein stability in S phase both in unperturbed cells and in cells exposed to DNA damaging agents or DNA replication inhibitors.
Propiedades químicas
Consulta técnica sobre: 01-4104898 Cdc25A (80-93) (human)
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