Clozapine - Bio-X ™

CAS: 5786-21-0

Ref. 3D-BC164328

Información del producto

• Nombre: Clozapine - Bio-X ™
• Sinónimos: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine HF-1854, 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Apo-Clozapine, Asaleptin, Azaleptin, Azaleptine, Brn 0764984, Ccris 9171, Clorazil, Cloril, Clozapex, Clozapin, Clozapina, Clozapina [INN-Spanish], Clozapinum, Clozapinum [INN-Latin], Clozaril, Fazaclo, Fazaclo ODT, Hf-1854, Hsdb 6478, Iprox, Klozapol, Leponex, Lx 100-129, Sizopin, Unii-J60Ar2Ikic, W-801

Descripción

Clozapine, a dibenzodiazepine, demonstrates antagonistic activity at the dopamine receptors, further binding to serotonin (5-HT1A, 5-HT2A-C, 5-HT6, 5-HT7), alpha 1 and 2 adrenergic, histamine 1 and M1-M5 muscarinic receptors. In particular, its partial 5-HT1A agonist behaviour, its low affinity for the D2 Dopamine receptors and its antagonistic activity at 5-HT2A receptors, are properties, which make it useful as an antipsychotic drug. The FDA has approved Clozapine for use in the alleviation of symptoms in treatment-resistant schizophrenia patients, such as the risk of self-harm. Although not yet approved by the FDA, Clozapione exerts positive effects in Parkinson’s disease and bipolar disorder treatments. However, Clozapione is not currently a first line-therapy option, as it may cause agranulocytosis and other side effects such as orthostatic hypotension and hypersalivation.

Clozapine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 326.82 g/mol
• Fórmula: C₁₈H₁₉ClN₄
• Pureza: Min. 95%
• Color/Forma: Yellow Powder