Org-26576
CAS: 1026791-61-6
Ref. 3D-BRB79161
| 5mg | A consultar | |
| 10mg | A consultar | |
| 25mg | A consultar | |
| 50mg | A consultar | |
| 100mg | A consultar |
Información del producto
Org-26576 is a potent and selective antagonist of the neurotrophic receptor TrkB. It binds to the extracellular domain of human TrkB, blocking the interaction with its ligands, including brain-derived neurotrophic factor and basic fibroblast growth factor. Org-26576 has shown antidepressant effects in animal models of depression, but this effect is dose-dependent. The compound also inhibits glutamate neurotransmission by competitively blocking N-methyl D-aspartate receptors. Org-26576 has been shown to be safe for use in animals and humans, with no serious adverse events reported so far. Pharmacokinetic studies show that Org-26576 crosses the blood brain barrier and is rapidly absorbed after oral administration.
Propiedades químicas
Consulta técnica sobre: 3D-BRB79161 Org-26576
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