HBsAg Mouse Monoclonal Antibody

Ref. 3D-CK1374-R

Información del producto

• Nombre: HBsAg Mouse Monoclonal Antibody
• Marca: Biosynth
• Descripción: Purified by Protein A chromatography in PBS, pH 7.4, this mouse monoclonal antibody product is complementary to native hepatitis B surface antigen (HBsAg) and is available as two clones: 1005011 and 1005021. Potential applications of this Mab are in ELISA and lateral flow assays and in the diagnosis of the Hepatitis B (HB) infection which is a necroinflammatory liver disease with the potential to cause liver cirrhosis and heptacellular carcinoma. Clone 1005021 is recommended as a capture antibody and clone 1005011 is recommended as detection antibody.The term HBsAg collectively refers to the three particle forms: Dane, filamentous and spherical of the HB virus which are made up of small HBs proteins (SHBs), middle HBs proteins (MHBs) and large HBs proteins (LHBs). These HBsAg proteins envelop the viral nucleocapsid and binds to the viral core. The LHB has a pre-S1, pre-S2 and S domain, the MHB does not have this pre-S1 domain while SHBs only have the S domain. The S domains ability to form disulphide cross-linked dimers allows Dane particles of the HBsAg to interact with sulphated proteoglycans on host cells, resulting in the activation of HB infection. Furthermore residues 2-48 which make up a conserved N-terminal sequence on the pre-S1 domain allows HBsAg to bind to the Na+-Taurocholate Co-transporter Polypeptide (NTCP) on hepatocytes.