Apolipoprotein KV domain (67 - 77)

Ref. 3D-CRB1000161

Información del producto

• Nombre: Apolipoprotein KV domain (67 - 77)
• Sinónimos: H-YTMNPRKLFDY-OH

Descripción

Vascular lipid deposition and altered lipid profiles are typical when unregulated angiogenesis is occurring, it is often seen in vascular disorders such as cancer and atherosclerosis. Apolipoprotein a (ApoA) functions as part of the lipid transporter complex high-density lipoproteins (HDL) to ensure lipid homeostasis and therefore the balance of angiogenesis. Within ApoA the Kringle5 (KV) domain (67 - 77), also known as KV11, has been identified as the region of ApoA that exerts anti-angiogenic effect. KV11 was shown in tumour cells to inhibit angiogenesis and consequently inhibits tumour progression. KV11 targets the angiogenesis c-Src/ERK pathway by blocking the activation signals received from vascular endothelial growth factor (VEGF). KV11 provides a new research potential for an anti-angiogenesis and anti-tumour therapeutic agent.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 1,447.66 g/mol