Biotin HER-2 substrate peptide

Ref. 3D-CRB1000260

Información del producto

• Nombre: Biotin HER-2 substrate peptide
• Sinónimos: Biot-GGMEDIYFEFMGGKKK-NH2Biotin HER2 substrate

Descripción

Human epidermal growth factor receptor (HER-2)/epidermal growth factor receptor-2 (ErbB-2), is a key receptor linked to metastasis in tumours. The oncogenic ErbB-2 receptor has intrinsic receptor tyrosine kinase (RTK) activity, the receptor is activated by ligand binding which induces receptor dimerization. These RTK complexes can activate mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI3K)/Akt pathways. This peptide has been identified as a substrate for HER-2/ErbB-2 as it is phosphorylated upon receptor activation and therefore acts as a marker for receptor activation in kinases assays. Contains a covalently attached N-terminal biotin tag for convenient detection and purification.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 2,062.44 g/mol