Adrenomedullin (22-52)

Ref. 3D-CRB1001438

Información del producto

• Nombre: Adrenomedullin (22-52)
• Sinónimos: H-TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-amideH-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-As p-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg- Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2

Descripción

Adrenomedullin (ADM), is a free circulating peptide of the amylin/calcitonin gene-related peptide (CGRP) super-family. It is widely expressed in virtually all human tissues and is involved in regulation of endothelial barrier function- vascular tone- immunoregulation- cellular proliferation and apoptosis. ADM is implicated in the pathophysiology of several diseased states including: sepsis- heart failure- inflammatory bowel disease- diabetes- eye pathologies and many cancers. ADM levels are often increased during these diseased states often correlating with disease severity and mortality. ADM is therefore of interest as a target for these diseases. ADM also displays potent antimicrobial action against Gram-positive and Gram-negative bacteria.The 52 amino acid ADM is produced by multiple cleavage steps from the original 85 amino acid long preprohormone (prepro-ADM). ADM exerts its effects by ligation of receptor complexes consisting of the calcitonin receptor-like receptor (CRLR) combined with a specific receptor activity-modifying protein (RAMP). Interaction of ADM with its receptor occurs through its C-terminal moiety.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 3,573.9 g/mol