SMAC/DIABLO [Lys(5-FAM)]

Ref. 3D-CRB1100325

Información del producto

• Nombre: SMAC/DIABLO [Lys(5-FAM)]
• Sinónimos: AVPIAQKSE--acidH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Ser-Glu--OH(N-Cbz-Nle-KRR)2-[R110], (N-Cbz-Nle-Lys-Arg-Arg)2-[Rh110]

Descripción

SMAC/DIABLO [Lys(5-FAM)] is a pro-apoptotic peptide that is derived from the mitochondrial protein known either as Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (DIABLO). During apoptosis the mitochondria has increased permeability to Smac/DIABLO, which causes the protein to diffuse into the cytosol. Here, Smac/DIABLO adheres to Inhibitors of apoptosis proteins (IAPs) and prevents them from binding to caspases, which in turn accentuates apoptosis.This peptide has a C-terminal lysine linker labelled with 5-Carboxyfluorescein (5-FAM), a widely used, green fluorescent tag.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 1,427.7 g/mol
• Color/Forma: Powder