[5-FAM]-GLP-1 (7-36)

Ref. 3D-CRB1100877

Información del producto

• Nombre: [5-FAM]-GLP-1 (7-36)
• Sinónimos: 5fam-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-NH2[5-FAM]-HAEGTFTSDVSSYLEGQAAKEFIAWLVKGR-amide[5-FAM]-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val -Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys -Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

Descripción

The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life <-2 minutes) due to proteolytic degradation by the serine protease- dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical useThis peptide contains N-terminal 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 3,653.7 g/mol