GLP (7-36) Heavy
Ref. 3D-CRB1300394
| 25nMol | 460,00 € |
Información del producto
- H-HAEGTF^TSDVSSYL^EGQAAKEFIAWL^VKGR-NH2HAEGT-[U-13C9,15N-Phe]-TSD-V-SSY-[U-13C6,15N-LEU]-EGQAAKEFIAW-[U-13C6,15N-Leu]-VKGR-amideH- His-Ala-Glu-Gly-Thr-[U-13C9,15N-Phe]
The native form of GLP-1 in humans is the GLP-1 (7-36) amide. GLP-1 (7-36) amide is highly unstable (half-life <-2 minutes) due to proteolytic degradation by the serine protease- dipeptidyl peptidase-IV (DPP-IV). DPP-IV cleaves the N-terminal histidine and alanine residues from GLP-1 to generate two equipotent forms: GLP-1 (9-37) and GLP-1 (9-36) amide. This degradation mitigates against the therapeutic use of GLP-1 itself, therefore DPP-IV-resistant peptide analogues have been developed and licensed for clinical use.In this peptide the phenylalanine residue at position 6 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1), the leucine residue at position 14 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1), and the leucine residue at position 26 is isotopically labelled with Carbon-13 (6) and Nitrogen-15 (1). Additionally, the peptide contains an uncharged C-terminal amide.
Propiedades químicas
Consulta técnica sobre: 3D-CRB1300394 GLP (7-36) Heavy
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