Bradykinin Heavy

Ref. 3D-CRB1301044

Información del producto

• Nombre: Bradykinin Heavy
• Sinónimos: RP-[U-13C5,15N-Pro]-GFSCFR-acidH-Arg-Pro-[U-13C5,15N-Pro]-Gly-Phe-Ser-Cys-Phe-Arg-OH

Descripción

Bradykinins and their associated kinins are inflammatory mediators produced during inflammation. The two main kinins in mammals are the nonapeptide bradykinin, BK (1-9) and the decapeptide kallidin (KD), [Lys0]-BK(1-10). Their biological actions are mediated by two distinct receptors, termed B1 and B2.BK is involved in several pathophysiological processes, such as inflammation, pain, cell proliferation, and tumours. It plays a crucial role in corneal epithelial cells, corneal stromal cells, and fibroblasts.Inflammation has been reported as one significant hallmark of breast cancer in relation to tumour development, metastasis, and invasion. The bradykinin receptor 1 (B1R) associated with kallidin is highly expressed on inflammatory breast tumour cells thus providing a promising targeting site for tumour recognition and sufficient receptor mediated endocytosis.The proline residue at position 3 is isotopically labelled with carbon-13 (5) and nitrogen-15 (1).

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 1,071.6 g/mol
• Pureza: Min. 95%