Anti-CDK2 antibody - 1mg/mL

Ref. 3D-CRB2005068

Información del producto

• Nombre: Anti-CDK2 antibody - 1mg/mL

Descripción

Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.

The activities of the CDKs are tightly controlled. CDK2 activities can be repressed by a set of inhibitors including P21. Dysregulation of the cell cycle and loss of proliferative controls is closely linked to cell transformation and cancer. CDK2 also appears to play a positive role in cell cycle arrest in the DNA damage response (DDR), its inhibition hinders the DDR, and sensitises cells to ionizing radiation, inducing cell death.

Data: Anti-CDK2 antibody (crb2005068) (1µg/ml).
Western blot analysis of whole cell extract human embryonic kidney cells HEK293 cells (30µg) and human prostate cancer CWR cells (30µg) .
Lane 1:HEK293 (30ug).

• Marca: Biosynth