Anti-B-Raf antibody - 0.1mg/mL

Ref. 3D-CRB2005114

Información del producto

• Nombre: Anti-B-Raf antibody - 0.1mg/mL

Descripción

B-Raf (BRAF) is a raf-family serine/threonine kinase and proto-oncogene involved in directing cell growth. The Raf kinases are subject to a complex activation process that integrates various protein-protein and protein-lipid interactions and positive as well as negative phosphorylation events. The Ras/Raf/mitogen-activated/extracellular-regulated kinase (MEK)/extracellular signal regulated kinase (ERK) pathway plays a pivotal role in controlling proliferation, survival and differentiation of metazoan cells.

B-Raf, the most potent kinase of the family, plays an important role in various developmental processes. B-Raf is also the most frequently mutated kinase in cancer, making it an important target for cancer treatment, especially in melanoma and hairy cell leukaemia. BRAF mutations are also found in the neuro-cardio-facio-cutaneous syndromes or RASopathies.

Data: Western blot analysis of whole cell extract of human Burkitt's lymphoma lymphoblasts (Daudi) (30 ug).
Lane 1: Daudi cells
Secondary: Goat anti-rabbit IgG conjugated to HRP (Vector) 1:2500

• Marca: Biosynth