Anti-IL23A antibody - 1mg/mL

Ref. 3D-CRB2005774

Información del producto

• Nombre: Anti-IL23A antibody - 1mg/mL
• Marca: Biosynth
• Descripción: Together with IL12B, IL23A forms part of the heterodimeric cytokine IL-23 which functions in innate and adaptive immunity. IL-23 is a member of the IL-12 family of cytokines that includes IL-12, IL-35, IL-27, and IL-39. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R and activates the Jak-Stat signaling cascade. IL-23 is a key driver of Th17-mediated immune response during infection and inflammation and its over production is involved in several cancers._x000D__x000D_IL23A expression is induced by several mechanisms including Tumour necrosis factor (TNF)/NF-kB, mitogen-activated protein kinase (MAPK) signalling and the formation of a transcriptional enhancer complex consisting of proto-oncogene c-Jun (c-Jun), RELA proto-oncogene NF-kB subunit (RelA), RUNX family transcription factor 1 (RUNX1), and RUNX3. Collectively, these proteins induced IL23A secretion._x000D__x000D_IL-23 is produced by dendritic cells and macrophages as well as keratinocytes and gastric; intestinal; lung and ovarian epithelial cells.