Protac K-ras degrader-1
CAS: 2378258-52-5
Ref. 3D-DVD25852
| 1mg | A consultar | ||
| 5mg | A consultar | ||
| 10mg | A consultar |
Información del producto
PROTAC K-RAS degrader-1, a proteolysis-targeting chimera (PROTAC), is a potent and selective proteolysis-targeting chimera (PROTAC) designed to degrade the K-RAS G12C mutant protein. This heterobifunctional small molecule is composed of a cereblon (CRBN) E3 ligand that binds to the CRBN E3 ubiquitin ligase complex, a linker region, and a K-RAS-binding moiety that selectively recognizes and binds to the K-RAS G12C mutant protein. Upon binding to CRBN and K-RAS G12C, PROTAC K-RAS degrader-1 acts as a molecular glue, bringing the E3 ligase close to K-RAS, leading to its ubiquitination and subsequent proteasomal degradation. Preclinical studies have demonstrated its potent degradation efficacy in K-RAS G12C-driven cancer cell lines, leading to inhibition of cell proliferation and tumor regression in xenograft models, offering a promising therapeutic approach for the treatment of K-RAS-driven cancers by directly degrading the oncogenic driver K-RAS(G12C) protein.
Propiedades químicas
Consulta técnica sobre: 3D-DVD25852 Protac K-ras degrader-1
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