Mps1-IN-2
CAS: 1228817-38-6
Ref. 3D-DZB81738
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Información del producto
Mps1-IN-2 is a potent and selective inhibitor of the mitotic kinase Mps1. It binds to the ATP-binding site of Mps1 and inhibits its activity, leading to cell death by apoptosis or necrosis. Mps1-IN-2 has shown anti-tumor activity against cancer cells in vitro and in vivo without any significant side effects, making it an attractive candidate for cancer therapy. The crystal structure of Mps1-IN-2 bound to the kinase domain revealed that it binds to a pocket with high affinity, where ATP binding leads to conformational changes that affect the other domains of the enzyme. This study has also shown that Mps1-IN-2 inhibits spindle formation and cellular proliferation in cancer cells.
Propiedades químicas
Consulta técnica sobre: 3D-DZB81738 Mps1-IN-2
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