3D-EAA85374 - isopropyl-methyl-sulfone

Applications Isopropyl p-Tosylate is a sulfonic acid ester, a potentialy alkylating agent. Studies suggest Isopropyl p-Tosylate may exert genotoxic effects in bacterial and mammalian cell systems.
References Glowienke, S. et al.: Mutat. Res. Gen. Toxicol. Environ. Mutagen., 581, 23 (2005); Sobol, Z. et al.: Mutat. Res. Gen. Toxicol. Environ. Mutagen., 633, 80 (2007);

Applications Ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic sensitivity to taxol.
References Barrington, R.E., et al.: Mol. Cell. Biol., 18, 85 (1998, Sepp-Lorenzo, L. and Rosen, N.: J. Biol. Chem., 273, 20243 (1998), Moasser, M.M., et al.: Proc. Natl. Acad. Sci. USA, 95, 1369 (1998), Law, B.K., et al.: J. Biol. Chem., 275, 10796 (2000),

Applications A toxic metabolite of Fenamiphos, a pesticide in fruits and vegetables.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schenck, F., et al.: Bull. Environ. Contam. Toxicol., 73, 24 (2004), Okihashi, M., et al.: J. Pestic. Sci., 30, 368 (2005), Lopez, M., et al.: J. Agric. Food Chem., 56, 1553 (2008),