6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine - Moscerdam™ biochemical purity

CAS: 904315-61-3

Ref. 3D-EH31028

Información del producto

• Nombre: 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine - Moscerdam™ biochemical purity
• Sinónimos: NPAB
• Marca: Biosynth
• Descripción: 6-Hexadecanoylamino-4-methylumbelliferyl phosphorylcholine (HMUPC) is a fluorogenic substrate of acid sphingomyelinase (ASM) in the application of the diagnosis of Niemann–Pick type A and B (NPAB). NPAB is one of the lysosomal storage diseases, caused by a deficiency of ASM. This deficiency results in the accumulation of sphingomyelin and other lipids in various tissues. The assay using HMUPC as the substrate shows rapid and robust determination of ASM activity. When combined with the unlabelled natural substrate such as sphingomyelin as a specific inhibitor of ASM activity, the specificity of assay is enhanced up to the level of the classical assay with radiolabelled natural substrate. HMUPC is also used as the substrate in the ASM assay to investigate the retention of lysosomal enzyme activity of bi-functional IgG-ASM fusion protein in the delivery across blood-brain barrier.

Propiedades químicas

• Peso molecular: 594.72 g/mol
• Fórmula: C₃₁H₅₁N₂O₇P
• Pureza: Min. 97 Area-%
• Color/Forma: White Powder