Omega-Agatoxin IVa trifluoroacetate

CAS: 145017-83-0

Ref. 3D-FA108461

Información del producto

• Nombre: Omega-Agatoxin IVa trifluoroacetate
• Sinónimos: H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-As n-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH trifluoroacetate, Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala, Omega-Aga-Ivb, Omega-Aga-Tk, Omega-Agatoxin Tk (P-Type Blocker), Omega-Agatoxin Tk, Agelenopsis Aperta, Snx 290, Ω-Aga-Tk, Ω-Agatoxin Tk, ω-Aga-IV A, ω-Agatoxin IV A (funnel-web spider venom), ω-Agatoxin IVA

Descripción

Omega-agatoxin IVa trifluoroacetate is a neurotoxin that inhibits voltage-dependent calcium channels. It blocks the opening of these channels, leading to an increase in cytosolic calcium. This toxin has been shown to be effective in treating autoimmune diseases and also has shown antimicrobial effects against bacteria. Omega-agatoxin IVa trifluoroacetate has a pathogenic mechanism that involves the inhibition of neuronal death by glutamate through its ability to block the release of glutamate from the presynaptic neuron. This toxin also binds to cerebellar Purkinje neurons and prevents them from firing, which leads to paralysis. Omega-agatoxin IVa trifluoroacetate is a glycosylated peptide with a disulfide bond that can be isolated using preparative high performance liquid chromatography (HPLC).

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 5,202.26 g/mol
• Fórmula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀
• Pureza: Min. 95%