(2R)-Arimoclomol maleate

CAS: 289893-26-1

Ref. 3D-FA159627

Información del producto

• Nombre: (2R)-Arimoclomol maleate
• Sinónimos: N-{[(2R)-2-Hydroxy-3-piperidin-1-ylpropyl]oxy}pyridine-3-carboximidoyl Chloride 1-Oxide maleic acid, 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1) (salt), BRX 220, 3-Pyridinecarboximidoyl chloride, N-[(2R)-2-hydroxy-3-(1-piperidinyl)propoxy]-, 1-oxide, (2Z)-2-butenedioate (1:1)

Descripción

(2R)-Arimoclomol maleate is a prodrug that is metabolized to the active drug, dimebon. It has been shown to inhibit the interaction of Hsp70 with its substrate, which in turn inhibits the activity of Hsp70. This inhibition prevents the accumulation of misfolded proteins and thus prevents cytotoxicity. (2R)-Arimoclomol maleate is also a linker for enzymatic activity and interacts with residues in proteins that are involved in signal transduction. It can modulate the onset of action and duration of effect by altering the level of active drug present.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 429.85 g/mol
• Fórmula: C₁₈H₂₄ClN₃O₇
• Pureza: Min. 98 Area-%
• Color/Forma: White Powder