(3S,4S)-4-Amino-3-hydroxy-5-phenylpentanoic acid
CAS: 72155-50-1
Ref. 3D-FA48184
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Información del producto
- AHPPA-OH
- (-)-Ahppa
- (3S,4S)-Ahppa
- (S,S)-4-Amino-3-hydroxy-5-phenylpentanoic acid
(3S,4S)-4-Amino-3-hydroxy-5-phenylpentanoic acid is an analog of (2R,3R)-2-amino-3-(hydroxymethyl)butanoic acid. It has been shown to be a potent inhibitor of the enzyme dipeptidyl peptidase IV (DPPIV), which breaks down tripeptides and inhibits immune responses. This inhibition causes hypotension in rats and humans. (3S,4S)-4-Amino-3-hydroxy-5-phenylpentanoic acid also has an isostere group that can be used as a substrate analogue for the formation of tripeptides. The hydrogen bond with the hydroxyl group on C1' plays an important role in its potency as an inhibitor of DPPIV.
Propiedades químicas
Consulta técnica sobre: 3D-FA48184 (3S,4S)-4-Amino-3-hydroxy-5-phenylpentanoic acid
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