Buparvaquone

CAS: 88426-33-9

Ref. 3D-FB19355

Información del producto

• Nombre: Buparvaquone
• Sinónimos: 2-[[4-(1,1-Dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedioneButalex, 1,4-Naphthalenedione, 2-[[4-(1,1-dimethylethyl)cyclohexyl]methyl]-3-hydroxy-, 2-((4-(1,1-Dimethylethyl)Cyclohexyl)Methyl)-3-Hydroxy-4-Naphthalenedione, 2-[(4-Tert-Butylcyclohexyl)Methyl]-3-Hydroxynaphthalene-1,4-Dione, 2-[[4-(1,1-Dimethylethyl)cyclohexyl]methyl]-3-hydroxy-1,4-naphthalenedione, 3-[(4-Tert-Butylcyclohexyl)Methyl]-4-Hydroxynaphthalene-1,2-Dione, Butalex

Descripción

Buparvaquone is an anti-inflammatory agent that is used in the treatment of infectious diseases caused by leishmania. It has been shown to be effective in vitro and in vivo against Leishmania amazonensis, L. braziliensis, and L. major, but not against L. infantum or L. donovani. Buparvaquone inhibits chemotaxis of white blood cells to inflammatory sites by binding to chemoattractant protein C5a receptors on the surface of these cells, which prevents the recruitment of more inflammatory cells into the site. This drug also inhibits IL-2 receptor activity and has been shown to have a protective effect against acute toxicities when combined with antioxidant vitamins A and E in vitro assays.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 326.43 g/mol
• Fórmula: C₂₁H₂₆O₃
• Pureza: Min. 98 Area-%
• Color/Forma: Off-White Powder