4-Bromoindazole

CAS: 186407-74-9

Ref. 3D-FB29052

Información del producto

• Nombre: 4-Bromoindazole
• Sinónimos: 4-Bromo(1H)Indazole, 4-Bromo-1H-Indazole

Descripción

4-Bromoindazole is an antibacterial agent that binds to the protonated form of the staphylococcal enzyme methicillin-resistant penicillinase (MRP) and prevents the enzyme from participating in the synthesis of cell wall precursors. The molecular modeling studies of 4-bromoindazole have shown that it can bind to pyogenes, a bacterium that causes streptococcal pharyngitis, by hydrogen bonding between its amide group and pyogenes' carboxylic acid group. 4-Bromoindazole also has anticancer activity against cancer cells with v600e mutation. It has been shown that 4-bromoindazole inhibits cancer cell proliferation by binding to the oxacillin site on DNA gyrase and topoisomerase IV, leading to DNA damage and apoptosis.

• Marca: Biosynth

Propiedades químicas

• Pureza: Min. 95%