4-Bromo-2,6-difluorobenzyl alcohol

CAS: 162744-59-4

Ref. 3D-FB69822

Información del producto

• Nombre: 4-Bromo-2,6-difluorobenzyl alcohol
• Sinónimos: 6-Difluoro-4-Bromobenzylalcohol, Rarechem Al Bd 1306, 4-Bromo-2,6-difluorobenzylalcohol, (4-Bromo-2,6-Difluorophenyl)Methanol, (4-Bromo-2,6-difluoro-phenyl)-methanol
• CAS: 162744-59-4

Descripción

4-Bromo-2,6-difluorobenzyl alcohol (4BDFA) is a molecule that has been shown to be able to produce magnetic resonance images. It can be used in tumor diagnosis as well as in the imaging of tumors. 4BDFA is synthesized by coupling 2,6-difluoroaniline with bromoacetaldehyde diethyl acetal. The syntheses are carried out under phase transfer catalysis conditions and the reaction is monitored by thin layer chromatography.
The synthesis of 4BDFA starts with the preparation of 2,6-difluoroaniline via a Grignard reaction between aniline and magnesium metal. The Grignard reagent is then added to bromoacetaldehyde diethyl acetal in dichloromethane followed by addition of triethylamine dropwise to maintain pH neutrality. The product is then extracted from the organic solution using ethyl ether

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 223.01 g/mol
• Fórmula: C₇H₅BrF₂O
• Pureza: Min. 95%
• Color/Forma: Powder