2-Chloro-5-nitrobenzene sulfonamide

CAS: 96-72-0

Ref. 3D-FC00928

Información del producto

• Nombre: 2-Chloro-5-nitrobenzene sulfonamide
• Sinónimos: 2-Chloro-5-Nitrobenzene Sulfonamide, 2-Chloro-5-Nitrobenzenesulfonamide, 2-Chloro-5-nitrobenzene-1-sulfonamide, Benzenesulfonamide, 2-chloro-5-nitro-, NSC 105711

Descripción

2-Chloro-5-nitrobenzene sulfonamide (2CNS) is a glycol ether that has been shown to inhibit the activity of carbonic anhydrase. It has been shown to be a competitive inhibitor of the enzyme, and can be used as a lead compound for developing new drugs. 2CNS has been shown to inhibit an anhydrase that is found in bacteria, such as Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus. This inhibition causes increased levels of hydrogen ions in the bacterial environment, which leads to the acidification of their surroundings. 2CNS also inhibits chloride ion uptake in these bacteria.
2CNS's pharmacophore includes two aromatic hydrocarbon rings with at least one hydrogen bond acceptor group on each ring. This pharmacophore is responsible for its inhibition of carbonic anhydrase and chloride ion binding site.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 236.63 g/mol
• Fórmula: C₆H₅ClN₂O₄S
• Pureza: Min. 97 Area-%
• Color/Forma: White Off-White Powder