4-Chloro-3-chlorosulfonylbenzoic acid
CAS: 2494-79-3
Ref. 3D-FC05455
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Información del producto
- 3-(Chlorosulfonyl)-4-chlorobenzoic acid
- 3-Carboxy-6-chlorobenzenesulfonyl chloride
- 4-Chloro-3-(Chlorosulfonyl)Benzoic Acid
- 4-Chloro-3-Chlorosulfonylbenzoic Acid
- Benzoic acid, 4-chloro-3-(chlorosulfonyl)-
4-Chloro-3-chlorosulfonylbenzoic acid is a potent inhibitor of the shikimate pathway and has been shown to be an anti-tuberculosis agent. The compound has a chloro substituent at the 4 position, which allows it to act as an electron-withdrawing group that stabilizes the transition state. This substitution also increases the activity by 10 times, providing an explanation for its potency against tuberculosis. The active site of 4-chloro-3-chlorosulfonylbenzoic acid is located in the chorismate binding pocket of shikimate dehydrogenase, where it acts as a competitive inhibitor. The crystal structure of this inhibitor bound to shikimate dehydrogenase has been determined by x-ray crystallography and shows that the lead compound binds in a manner similar to other inhibitors with high affinity.
4-Chloro-3-chlorosulfonylbenzoic acid
Propiedades químicas
Consulta técnica sobre: 3D-FC05455 4-Chloro-3-chlorosulfonylbenzoic acid
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