6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
CAS: 1242156-53-1
Ref. 3D-FC161324
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Información del producto
6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one is a potent and selective inhibitor of tyrosine kinases. The compound was discovered by screening for inhibitors of the PDGF receptor in a cellular assay. The structure activity relationship analysis revealed that the 6-cyclopropyl group and 8-fluoroisoquinoline moiety are critical for the inhibitory potency and selectivity. In particular, the 8-fluoroisoquinoline moiety is important for binding to the ATP site on PDGFRs, as well as for binding to other tyrosine kinases such as c-Met, c-Kit, cRaf, cSrc, and EGFR. 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one has been shown to have potential therapeutic applications in rheumatoid arthritis by inhibiting the production of proinflammatory cytokines in
Propiedades químicas
Consulta técnica sobre: 3D-FC161324 6-Cyclopropyl-8-fluoroisoquinolin-1(2H)-one
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