6-Chloroisatin

CAS: 6341-92-0

Ref. 3D-FC32700

Información del producto

• Nombre: 6-Chloroisatin
• Sinónimos: 6-Chloroindole-2,3-dione6-Chloro-2,3-indolinedione, Buttpark 50\07-92, 6-Chloro-1H-Indole-2,3-Dione, 3-(5-{(E)-[1-(3-bromophenyl)-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene]methyl}furan-2-yl)-4-methylbenzoic acid

Descripción

6-Chloroisatin is a potent inhibitor of bacterial growth that binds to the 50S ribosomal subunit. It has been shown to have strong inhibitory activity against tuberculosis and sulphamethoxazole-resistant strains of Mycobacterium tuberculosis. 6-Chloroisatin inhibits bacterial growth by binding to the 50S ribosomal subunit, thereby preventing protein synthesis and cell division. The electron deficient form of 6-chloroisatin reacts with the electron rich sulphamethoxazole by displacement of chloride ion from the sulphonamide ring, forming a regiospecific product that inhibits bacterial respiration. This reaction system is inhibited by activated carbon, which may be a potential therapeutic strategy for patients with drug resistant tuberculosis.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 181.58 g/mol
• Fórmula: C₈H₄ClNO₂
• Pureza: Min. 95%