8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline

CAS: 124495-31-4

Ref. 3D-FC89837

Información del producto

• Nombre: 8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline
• Sinónimos: Ly 214352, Ly214352

Descripción

8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline is a selectable antibiotic that inhibits the synthesis of amino acids. It blocks the dehydrogenase enzyme, which catalyzes the conversion of 2-ketoglutarate to succinyl-CoA, an intermediate in the Krebs cycle and a precursor for amino acid biosynthesis. This leads to a build up of 2-ketoglutarate, which is toxic to cells. 8-Chloro-4-(2-Chloro-4-Fluorophenoxy)Quinoline has been shown to be effective against wild type strains and resistant mutants of filamentous fungi and can also be used as a model organism for studying other antifungal agents.

• Marca: Biosynth

Propiedades químicas

• Peso molecular: 308.13 g/mol
• Fórmula: C₁₅H₈Cl₂FNO
• Pureza: Min. 95%
• InChI: InChI=1S/C15H8Cl2FNO/c16-11-3-1-2-10-13(6-7-19-15(10)11)20-14-5-4-9(18)8-12(14)17/h1-8H
• Clave InChI: InChIKey=ZXLMSTBJMZJAAH-UHFFFAOYSA-N
• SMILES: Fc1ccc(Oc2ccnc3c(Cl)cccc23)c(Cl)c1