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5-[Di(tert-butyl)phosphino]-1',3',5'-triphenyl-1'H-[1,4']bipyrazolyl
CAS: 894086-00-1
Ref. 3D-FD153324
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Información del producto
- 5-(Di-Tert-Butylphosphino)-1',3',5'-Triphenyl-1'H-[1,4']Bipyrazole
5-[Di(tert-butyl)phosphino]-1',3',5'-triphenyl-1'H-[1,4']bipyrazolyl is a palladium-catalyzed cross-coupling agent that inhibits the synthesis of fatty acids by inhibiting the enzyme delta-9 desaturase. It is an analogue of the natural product lapatinib and has been shown to inhibit tumor cell lines in vitro. 5-[Di(tert-butyl)phosphino]-1',3',5'-triphenyl-1'H-[1,4']bipyrazolyl binds to the active site of the enzyme, which prevents substrate binding and blocks the formation of a thioester bond with coenzyme A. This inhibition leads to decreased production of fatty acids from acetyl CoA.
Propiedades químicas
Consulta técnica sobre: 3D-FD153324 5-[Di(tert-butyl)phosphino]-1',3',5'-triphenyl-1'H-[1,4']bipyrazolyl
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